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06.10.2020 | Original

ECMO for severe ARDS: systematic review and individual patient data meta-analysis

verfasst von: Alain Combes, Giles J. Peek, David Hajage, Pollyanna Hardy, Darryl Abrams, Matthieu Schmidt, Agnès Dechartres, Diana Elbourne

Erschienen in: Intensive Care Medicine | Ausgabe 11/2020

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Abstract

Purpose

To assess the effect of venovenous extracorporeal membrane oxygenation (ECMO) compared to conventional management in patients with severe acute respiratory distress syndrome (ARDS).

Methods

We conducted a systematic review and individual patient data meta-analysis of randomised controlled trials (RCTs) performed after Jan 1, 2000 comparing ECMO to conventional management in patients with severe ARDS. The primary outcome was 90-day mortality. Primary analysis was by intent-to-treat.

Results

We identified two RCTs (CESAR and EOLIA) and combined data from 429 patients. On day 90, 77 of the 214 (36%) ECMO-group and 103 of the 215 (48%) control group patients had died (relative risk (RR), 0.75, 95% confidence interval (CI) 0.6–0.94; P = 0.013; I² = 0%). In the per-protocol and as-treated analyses the RRs were 0.75 (95% CI 0.6–0.94) and 0.86 (95% CI 0.68–1.09), respectively. Rescue ECMO was used for 36 (17%) of the 215 control patients (35 in EOLIA and 1 in CESAR). The RR of 90-day treatment failure, defined as death for the ECMO-group and death or crossover to ECMO for the control group was 0.65 (95% CI 0.52–0.8; I² = 0%). Patients randomised to ECMO had more days alive out of the ICU and without respiratory, cardiovascular, renal and neurological failure. The only significant treatment-covariate interaction in subgroups was lower mortality with ECMO in patients with two or less organs failing at randomization.

Conclusions

In this meta-analysis of individual patient data in severe ARDS, 90-day mortality was significantly lowered by ECMO compared with conventional management.

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Titel: ECMO for severe ARDS: systematic review and individual patient data meta-analysis
verfasst von: Alain Combes
Giles J. Peek
David Hajage
Pollyanna Hardy
Darryl Abrams
Matthieu Schmidt
Agnès Dechartres
Diana Elbourne
Publikationsdatum: 06.10.2020
Verlag: Springer Berlin Heidelberg
Erschienen in: Intensive Care Medicine / Ausgabe 11/2020
Print ISSN: 0342-4642
Elektronische ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-020-06248-3

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ECMO for severe ARDS: systematic review and individual patient data meta-analysis