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Erschienen in:

07.07.2021 | Narrative Review

Non-invasive ventilatory support and high-flow nasal oxygen as first-line treatment of acute hypoxemic respiratory failure and ARDS

verfasst von: Domenico Luca Grieco, Salvatore Maurizio Maggiore, Oriol Roca, Elena Spinelli, Bhakti K. Patel, Arnaud W. Thille, Carmen Sílvia V. Barbas, Marina Garcia de Acilu, Salvatore Lucio Cutuli, Filippo Bongiovanni, Marcelo Amato, Jean-Pierre Frat, Tommaso Mauri, John P. Kress, Jordi Mancebo, Massimo Antonelli

Erschienen in: Intensive Care Medicine | Ausgabe 8/2021

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Abstract

The role of non-invasive respiratory support (high-flow nasal oxygen and noninvasive ventilation) in the management of acute hypoxemic respiratory failure and acute respiratory distress syndrome is debated. The oxygenation improvement coupled with lung and diaphragm protection produced by non-invasive support may help to avoid endotracheal intubation, which prevents the complications of sedation and invasive mechanical ventilation. However, spontaneous breathing in patients with lung injury carries the risk that vigorous inspiratory effort, combined or not with mechanical increases in inspiratory airway pressure, produces high transpulmonary pressure swings and local lung overstretch. This ultimately results in additional lung damage (patient self-inflicted lung injury), so that patients intubated after a trial of noninvasive support are burdened by increased mortality. Reducing inspiratory effort by high-flow nasal oxygen or delivery of sustained positive end-expiratory pressure through the helmet interface may reduce these risks. In this physiology-to-bedside review, we provide an updated overview about the role of noninvasive respiratory support strategies as early treatment of hypoxemic respiratory failure in the intensive care unit. Noninvasive strategies appear safe and effective in mild-to-moderate hypoxemia (PaO₂/FiO₂ > 150 mmHg), while they can yield delayed intubation with increased mortality in a significant proportion of moderate-to-severe (PaO₂/FiO₂ ≤ 150 mmHg) cases. High-flow nasal oxygen and helmet noninvasive ventilation represent the most promising techniques for first-line treatment of severe patients. However, no conclusive evidence allows to recommend a single approach over the others in case of moderate-to-severe hypoxemia. During any treatment, strict physiological monitoring remains of paramount importance to promptly detect the need for endotracheal intubation and not delay protective ventilation.

Bellani G, Laffey JG, Pham T et al (2016) Epidemiology, patterns of care, and mortality for patients with acute respiratory distress syndrome in intensive care units in 50 countries. JAMA 315:788–800. https://doi.org/10.1001/jama.2016.0291CrossRefPubMed

Ferguson ND, Pham T, Gong MN (2020) How severe COVID-19 infection is changing ARDS management. Intensive Care Med 46:2184–2186. https://doi.org/10.1007/s00134-020-06245-6CrossRefPubMed

Jaber S, Citerio G, Slutsky AS (2020) Acute respiratory failure and mechanical ventilation in the context of the COVID-19 pandemic: why a special issue in ICM? Intensive Care Med 46:2131–2132. https://doi.org/10.1007/s00134-020-06298-7CrossRefPubMed

Murthy S, Gomersall CD, Fowler RA (2020) Care for critically Ill patients with COVID-19. JAMA 323:1499–1500. https://doi.org/10.1001/jama.2020.3633CrossRefPubMed

Definition Task Force ARDS, Ranieri VM, Rubenfeld GD et al (2012) Acute respiratory distress syndrome: the Berlin Definition. JAMA 307:2526–2533. https://doi.org/10.1001/jama.2012.5669CrossRef

Pham T, Pesenti A, Bellani G et al (2020) Outcome of Acute Hypoxaemic Respiratory Failure. Eur Respir J, Insights from the Lung Safe Study. https://doi.org/10.1183/13993003.03317-2020CrossRef

Bellani G, Laffey JG, Pham T et al (2017) Noninvasive ventilation of patients with acute respiratory distress syndrome. Insights from the LUNG SAFE Study. Am J Respir Crit Care Med 195:67–77. https://doi.org/10.1164/rccm.201606-1306OCCrossRefPubMed

Esnault P, Cardinale M, Hraiech S et al (2020) High respiratory drive and excessive respiratory efforts predict relapse of respiratory failure in critically Ill patients with COVID-19. Am J Respir Crit Care Med 202:1173–1178. https://doi.org/10.1164/rccm.202005-1582LECrossRefPubMedPubMedCentral

Tonelli R, Fantini R, Tabbì L et al (2020) Early inspiratory effort assessment by esophageal manometry predicts noninvasive ventilation outcome in de novo respiratory failure. A pilot study. Am J Respir Crit Care Med 202:558–567. https://doi.org/10.1164/rccm.201912-2512OCCrossRefPubMedPubMedCentral

10.

Grieco DL, Menga LS, Raggi V et al (2020) physiological comparison of high-flow nasal cannula and helmet noninvasive ventilation in acute hypoxemic respiratory failure. Am J Respir Crit Care Med 201:303–312. https://doi.org/10.1164/rccm.201904-0841OCCrossRefPubMed

11.

Ferreyro BL, Angriman F, Munshi L et al (2020) Association of noninvasive oxygenation strategies with all-cause mortality in adults with acute hypoxemic respiratory failure. JAMA 324:57. https://doi.org/10.1001/jama.2020.9524CrossRefPubMed

12.

Rochwerg B, Einav S, Chaudhuri D et al (2020) The role for high flow nasal cannula as a respiratory support strategy in adults: a clinical practice guideline. Intensive Care Med 46:2226–2237. https://doi.org/10.1007/s00134-020-06312-yCrossRefPubMed

13.

Rochwerg B, Brochard L, Elliott MW et al (2017) Official ERS/ATS clinical practice guidelines: noninvasive ventilation for acute respiratory failure. Eur Respir J. https://doi.org/10.1183/13993003.02426-2016CrossRefPubMed

14.

Franco C, Facciolongo N, Tonelli R et al (2020) Feasibility and clinical impact of out-of-ICU noninvasive respiratory support in patients with COVID-19-related pneumonia. Eur Respir J 56:2002130. https://doi.org/10.1183/13993003.02130-2020CrossRefPubMedPubMedCentral

15.

Franco C, Facciolongo N, Tonelli R et al (2020) Feasibility and clinical impact of out-of-ICU noninvasive respiratory support in patients with COVID-19-related pneumonia. Eur Respir J 56:122. https://doi.org/10.1183/13993003.02130-2020CrossRef

16.

COVID-ICU Group on behalf of the REVA Network and the COVID-ICU Investigators (2020) Clinical characteristics and day-90 outcomes of 4244 critically ill adults with COVID-19: a prospective cohort study. Intensive Care Med. https://doi.org/10.1007/s00134-020-06294-xCrossRef

17.

Mellado-Artigas R, Ferreyro BL, Angriman F et al (2021) High-flow nasal oxygen in patients with COVID-19-associated acute respiratory failure. Crit Care 25:58. https://doi.org/10.1186/s13054-021-03469-wCrossRefPubMedPubMedCentral

18.

Coppadoro A, Benini A, Fruscio R et al (2021) Helmet CPAP to treat hypoxic pneumonia outside the ICU: an observational study during the COVID-19 outbreak. Crit Care 25:80. https://doi.org/10.1186/s13054-021-03502-yCrossRefPubMedPubMedCentral

19.

Menga LS, Cese LD, Bongiovanni F et al (2021) High failure rate of noninvasive oxygenation strategies in critically Ill subjects with acute hypoxemic respiratory failure due to COVID-19. Respir Care. https://doi.org/10.4187/respcare.08622CrossRefPubMed

20.

Brusasco C, Corradi F, Di Domenico A et al (2021) Continuous positive airway pressure in COVID-19 patients with moderate-to-severe respiratory failure. Eur Respir J. https://doi.org/10.1183/13993003.02524-2020CrossRefPubMedPubMedCentral

21.

Luyt C-E, Bouadma L, Morris AC et al (2020) Pulmonary infections complicating ARDS. Intensive Care Med 46:2168–2183. https://doi.org/10.1007/s00134-020-06292-zCrossRefPubMed

22.

Antonelli M, Conti G, Rocco M et al (1998) A comparison of noninvasive positive-pressure ventilation and conventional mechanical ventilation in patients with acute respiratory failure. N Engl J Med 339:429–435. https://doi.org/10.1056/NEJM199808133390703CrossRefPubMed

23.

Slutsky AS, Ranieri VM (2013) Ventilator-induced lung injury. N Engl J Med 369:2126–2136. https://doi.org/10.1056/NEJMra1208707CrossRefPubMed

24.

Chanques G, Constantin J-M, Devlin JW et al (2020) Analgesia and sedation in patients with ARDS. Intensive Care Med 46:2342–2356. https://doi.org/10.1007/s00134-020-06307-9CrossRefPubMed

25.

Alhazzani W, Belley-Cote E, Møller MH et al (2020) Neuromuscular blockade in patients with ARDS: a rapid practice guideline. Intensive Care Med 46:1977–1986. https://doi.org/10.1007/s00134-020-06227-8CrossRefPubMed

26.

Squadrone V, Coha M, Cerutti E et al (2005) Continuous positive airway pressure for treatment of postoperative hypoxemia: a randomized controlled trial. JAMA 293:589–595. https://doi.org/10.1001/jama.293.5.589CrossRefPubMed

27.

Sassoon CSH, Zhu E, Caiozzo VJ (2004) Assist-control mechanical ventilation attenuates ventilator-induced diaphragmatic dysfunction. Am J Respir Crit Care Med 170:626–632. https://doi.org/10.1164/rccm.200401-042OCCrossRefPubMed

28.

Qvist J, Pontoppidan H, Wilson RS et al (1975) Hemodynamic responses to mechanical ventilation with PEEP: the effect of hypervolemia. Anesthesiology 42:45–55. https://doi.org/10.1097/00000542-197501000-00009CrossRefPubMed

29.

Repessé X, Charron C, Vieillard-Baron A (2012) Right ventricular failure in acute lung injury and acute respiratory distress syndrome. Minerva Anestesiol 78:941–948PubMed

30.

Wrigge H, Zinserling J, Neumann P et al (2003) Spontaneous breathing improves lung aeration in oleic acid-induced lung injury. Anesthesiology 99:376–384. https://doi.org/10.1097/00000542-200308000-00019CrossRefPubMed

31.

Ferrari S, Orlandi M, Avella M et al (1992) Effects of hydration on plasma concentrations of methotrexate in patients with osteosarcoma treated with high doses of methotrexate. Minerva Med 83:289–293. https://doi.org/10.1097/01.ccm.0000163226.34868.0aCrossRefPubMed

32.

Putensen C, Zech S, Wrigge H et al (2001) Long-term effects of spontaneous breathing during ventilatory support in patients with acute lung injury. Am J Respir Crit Care Med 164:43–49. https://doi.org/10.1164/ajrccm.164.1.2001078CrossRefPubMed

33.

Marini JJ (2011) Spontaneously regulated vs. controlled ventilation of acute lung injury/acute respiratory distress syndrome. Curr Opin Crit Care 17:24–29. https://doi.org/10.1097/MCC.0b013e328342726eCrossRefPubMed

34.

Yoshida T, Uchiyama A, Matsuura N et al (2013) The comparison of spontaneous breathing and muscle paralysis in two different severities of experimental lung injury. Crit Care Med 41:536–545. https://doi.org/10.1097/CCM.0b013e3182711972CrossRefPubMed

35.

Güldner A, Pelosi P, Gama de Abreu M (2014) Spontaneous breathing in mild and moderate versus severe acute respiratory distress syndrome. Curr Opin Crit Care 20:69–76. https://doi.org/10.1097/MCC.0000000000000055CrossRefPubMed

36.

Spinelli E, Mauri T, Beitler JR et al (2020) Respiratory drive in the acute respiratory distress syndrome: pathophysiology, monitoring, and therapeutic interventions. Intensive Care Med 46:606–618. https://doi.org/10.1007/s00134-020-05942-6CrossRefPubMedPubMedCentral

37.

Carteaux G, Millán-Guilarte T, De Prost N et al (2016) Failure of noninvasive ventilation for de novo acute hypoxemic respiratory failure: role of tidal volume. Crit Care Med 44:282–290. https://doi.org/10.1097/CCM.0000000000001379CrossRefPubMed

38.

Frat J-P, Ragot S, Coudroy R et al (2018) Predictors of intubation in patients with acute hypoxemic respiratory failure treated with a noninvasive oxygenation strategy. Crit Care Med 46:208–215. https://doi.org/10.1097/CCM.0000000000002818CrossRefPubMed

39.

Yoshida T, Fujino Y, Amato MBP, Kavanagh BP (2017) Fifty years of research in ARDS. Spontaneous breathing during mechanical ventilation. Risks, mechanisms, and management. Am J Respir Crit Care Med 195:985–992. https://doi.org/10.1164/rccm.201604-0748CPCrossRefPubMed

40.

Brochard L, Slutsky A, Pesenti A (2017) Mechanical ventilation to minimize progression of lung injury in acute respiratory failure. Am J Respir Crit Care Med 195:438–442. https://doi.org/10.1164/rccm.201605-1081CPCrossRefPubMed

41.

Mascheroni D, Kolobow T, Fumagalli R et al (1988) Acute respiratory failure following pharmacologically induced hyperventilation: an experimental animal study. Intensive Care Med 15:8–14. https://doi.org/10.1007/BF00255628CrossRefPubMed

42.

Yoshida T, Torsani V, Gomes S et al (2013) Spontaneous effort causes occult pendelluft during mechanical ventilation. Am J Respir Crit Care Med 188:1420–1427. https://doi.org/10.1164/rccm.201303-0539OCCrossRefPubMed

43.

Yoshida T, Roldan R, Beraldo MA et al (2016) Spontaneous effort during mechanical ventilation: maximal injury with less positive end-expiratory pressure. Crit Care Med 44:e678–e688. https://doi.org/10.1097/CCM.0000000000001649CrossRefPubMed

44.

Yoshida T, Nakahashi S, Nakamura MAM et al (2017) Volume-controlled ventilation does not prevent injurious inflation during spontaneous effort. Am J Respir Crit Care Med 196:590–601. https://doi.org/10.1164/rccm.201610-1972OCCrossRefPubMed

45.

Bhattacharya M, Kallet RH, Ware LB, Matthay MA (2016) Negative-pressure pulmonary edema. Chest 150:927–933. https://doi.org/10.1016/j.chest.2016.03.043CrossRefPubMed

46.

Goligher EC, Jonkman AH, Dianti J et al (2020) Clinical strategies for implementing lung and diaphragm-protective ventilation: avoiding insufficient and excessive effort. Intensive Care Med 46:2314–2326. https://doi.org/10.1007/s00134-020-06288-9CrossRefPubMedPubMedCentral

47.

Goligher EC, Brochard LJ, Reid WD et al (2019) Diaphragmatic myotrauma: a mediator of prolonged ventilation and poor patient outcomes in acute respiratory failure. Lancet Respir Med 7:90–98. https://doi.org/10.1016/S2213-2600(18)30366-7CrossRefPubMed

48.

Goligher EC, Fan E, Herridge MS et al (2015) Evolution of diaphragm thickness during mechanical ventilation. Impact of inspiratory effort. Am J Respir Crit Care Med 192:1080–1088. https://doi.org/10.1164/rccm.201503-0620OCCrossRefPubMed

49.

Grieco DL, Menga LS, Eleuteri D, Antonelli M (2019) Patient self-inflicted lung injury: implications for acute hypoxemic respiratory failure and ARDS patients on non-invasive support. Minerva Anestesiol 85:1014–1023. https://doi.org/10.23736/S0375-9393.19.13418-9CrossRefPubMed

50.

Yoshida T, Grieco DL, Brochard L, Fujino Y (2020) Patient self-inflicted lung injury and positive end-expiratory pressure for safe spontaneous breathing. Curr Opin Crit Care 26:59–65. https://doi.org/10.1097/MCC.0000000000000691CrossRefPubMed

51.

Roca O, Caralt B, Messika J et al (2019) An index combining respiratory rate and oxygenation to predict outcome of nasal high-flow therapy. Am J Respir Crit Care Med 199:1368–1376. https://doi.org/10.1164/rccm.201803-0589OCCrossRefPubMed

52.

Carrillo A, Gonzalez-Diaz G, Ferrer M et al (2012) Non-invasive ventilation in community-acquired pneumonia and severe acute respiratory failure. Intensive Care Med 38:458–466. https://doi.org/10.1007/s00134-012-2475-6CrossRefPubMed

53.

Demoule A, Girou E, Richard J-C et al (2006) Benefits and risks of success or failure of noninvasive ventilation. Intensive Care Med 32:1756–1765. https://doi.org/10.1007/s00134-006-0324-1CrossRefPubMed

54.

Kangelaris KN, Ware LB, Wang CY et al (2016) Timing of intubation and clinical outcomes in adults with acute respiratory distress syndrome. Crit Care Med 44:120–129. https://doi.org/10.1097/CCM.0000000000001359CrossRefPubMedPubMedCentral

55.

Olafsson S, Hyatt RE (1969) Ventilatory mechanics and expiratory flow limitation during exercise in normal subjects. J Clin Invest 48:564–573. https://doi.org/10.1172/JCI106015CrossRefPubMedPubMedCentral

56.

Guenette JA, Witt JD, McKenzie DC et al (2007) Respiratory mechanics during exercise in endurance-trained men and women. J Physiol 581:1309–1322. https://doi.org/10.1113/jphysiol.2006.126466CrossRefPubMedPubMedCentral

57.

Grieco DL, Menga LS, Conti G et al (2020) Reply to Spinelli and Mauri: lung and diaphragm protection during noninvasive respiratory support. Am J Respir Crit Care Med 201:876–878. https://doi.org/10.1164/rccm.201912-2321LECrossRefPubMedPubMedCentral

58.

Goligher EC, Dres M, Patel BK et al (2020) Lung- and diaphragm-protective ventilation. Am J Respir Crit Care Med 202:950–961. https://doi.org/10.1164/rccm.202003-0655CPCrossRefPubMed

59.

Vaschetto R, Cammarota G, Colombo D et al (2014) Effects of propofol on patient-ventilator synchrony and interaction during pressure support ventilation and neurally adjusted ventilatory assist. Crit Care Med 42:74–82. https://doi.org/10.1097/CCM.0b013e31829e53dcCrossRefPubMed

60.

Carson SS, Kress JP, Rodgers JE et al (2006) A randomized trial of intermittent lorazepam versus propofol with daily interruption in mechanically ventilated patients. Crit Care Med 34:1326–1332. https://doi.org/10.1097/01.CCM.0000215513.63207.7FCrossRefPubMed

61.

Pattinson KTS (2008) Opioids and the control of respiration. Br J Anaesth 100:747–758. https://doi.org/10.1093/bja/aen094CrossRefPubMed

62.

Bouillon T, Bruhn J, Roepcke H, Hoeft A (2003) Opioid-induced respiratory depression is associated with increased tidal volume variability. Eur J Anaesthesiol 20:127–133. https://doi.org/10.1017/s0265021503000243CrossRefPubMed

63.

Belleville JP, Ward DS, Bloor BC, Maze M (1992) Effects of intravenous dexmedetomidine in humans. I. Sedation, ventilation, and metabolic rate. Anesthesiology 77:1125–1133. https://doi.org/10.1097/00000542-199212000-00013CrossRefPubMed

64.

Kiss T, Bluth T, Braune A et al (2019) Effects of positive end-expiratory pressure and spontaneous breathing activity on regional lung inflammation in experimental acute respiratory distress syndrome. Crit Care Med 47:e358–e365. https://doi.org/10.1097/CCM.0000000000003649CrossRefPubMedPubMedCentral

65.

Morais CCA, Koyama Y, Yoshida T et al (2018) High positive end-expiratory pressure renders spontaneous effort noninjurious. Am J Respir Crit Care Med 197:1285–1296. https://doi.org/10.1164/rccm.201706-1244OCCrossRefPubMedPubMedCentral

66.

Evans CL, Hill AV (1914) The relation of length to tension development and heat production on contraction in muscle. J Physiol 49:10–16. https://doi.org/10.1113/jphysiol.1914.sp001684CrossRefPubMedPubMedCentral

67.

De Troyer A, Leduc D, Cappello M et al (2009) Mechanisms of the inspiratory action of the diaphragm during isolated contraction. J Appl Physiol 107:1736–1742. https://doi.org/10.1152/japplphysiol.00753.2009CrossRefPubMed

68.

Grieco DL, Menga LS, Cesarano M et al (2021) Effect of helmet noninvasive ventilation vs high-flow nasal oxygen on days free of respiratory support in patients with COVID-19 and moderate to severe hypoxemic respiratory failure: the HENIVOT randomized clinical trial. JAMA 325:1731–1743. https://doi.org/10.1001/jama.2021.4682CrossRefPubMed

69.

Ricard J-D, Roca O, Lemiale V et al (2020) Use of nasal high flow oxygen during acute respiratory failure. Intensive Care Med 46:2238–2247. https://doi.org/10.1007/s00134-020-06228-7CrossRefPubMed

70.

Papazian L, Corley A, Hess D et al (2016) Use of high-flow nasal cannula oxygenation in ICU adults: a narrative review. Intensive Care Med 42:1336–1349. https://doi.org/10.1007/s00134-016-4277-8CrossRefPubMed

71.

Parke RL, Eccleston ML, McGuinness SP (2011) The effects of flow on airway pressure during nasal high-flow oxygen therapy. Respir Care 56:1151–1155. https://doi.org/10.4187/respcare.01106CrossRefPubMed

72.

Parke R, McGuinness S, Eccleston M (2009) Nasal high-flow therapy delivers low level positive airway pressure. Br J Anaesth 103:886–890. https://doi.org/10.1093/bja/aep280CrossRefPubMedPubMedCentral

73.

Parke RL, McGuinness SP (2013) Pressures delivered by nasal high flow oxygen during all phases of the respiratory cycle. Respir Care 58:1621–1624. https://doi.org/10.4187/respcare.02358CrossRefPubMed

74.

Corley a., Caruana LR, Barnett a. G, et al (2011) Oxygen delivery through high-flow nasal cannulae increase end-expiratory lung volume and reduce respiratory rate in post-cardiac surgical patients. Br J Anaesth 107:998–1004. https://doi.org/10.1093/bja/aer265CrossRef

75.

Natalini D, Grieco DL, Santantonio MT et al (2019) Physiological effects of high-flow oxygen in tracheostomized patients. Ann Intensive Care 9:114. https://doi.org/10.1186/s13613-019-0591-yCrossRefPubMedPubMedCentral

76.

Möller W, Celik G, Feng S et al (2015) Nasal high flow clears anatomical dead space in upper airway models. J Appl Physiol 118:1525–1532. https://doi.org/10.1152/japplphysiol.00934.2014CrossRefPubMedPubMedCentral

77.

Möller W, Feng S, Domanski U et al (2017) Nasal high flow reduces dead space. J Appl Physiol 122:191–197. https://doi.org/10.1152/japplphysiol.00584.2016CrossRefPubMed

78.

Vargas F, Saint-Leger M, Boyer A et al (2015) Physiologic effects of high-flow nasal cannula oxygen in critical care subjects. Respir Care 60:1369–1376. https://doi.org/10.4187/respcare.03814CrossRefPubMed

79.

Delorme M, Bouchard P-A, Simon M et al (2017) Effects of high-flow nasal cannula on the work of breathing in patients recovering from acute respiratory failure. Crit Care Med 45:1981–1988. https://doi.org/10.1097/CCM.0000000000002693CrossRefPubMed

80.

Mauri T, Turrini C, Eronia N et al (2017) Physiologic effects of high-flow nasal cannula in acute hypoxemic respiratory failure. Am J Respir Crit Care Med 195:1207–1215. https://doi.org/10.1164/rccm.201605-0916OCCrossRefPubMed

81.

Sztrymf B, Messika J, Bertrand F et al (2011) Beneficial effects of humidified high flow nasal oxygen in critical care patients: a prospective pilot study. Intensive Care Med 37:1780–1786. https://doi.org/10.1007/s00134-011-2354-6CrossRefPubMed

82.

Parke RL, McGuinness SP, Eccleston ML (2011) A preliminary randomized controlled trial to assess effectiveness of nasal high-flow oxygen in intensive care patients. Respir Care 56:265–270. https://doi.org/10.4187/respcare.00801CrossRefPubMed

83.

Sim MAB, Dean P, Kinsella J et al (2008) Performance of oxygen delivery devices when the breathing pattern of respiratory failure is simulated. Anaesthesia 63:938–940. https://doi.org/10.1111/j.1365-2044.2008.05536.xCrossRefPubMed

84.

Mauri T, Alban L, Turrini C et al (2017) Optimum support by high-flow nasal cannula in acute hypoxemic respiratory failure: effects of increasing flow rates. Intensive Care Med 43:1453–1463. https://doi.org/10.1007/s00134-017-4890-1CrossRefPubMed

85.

Frat J-P, Thille AW, Mercat A et al (2015) High-flow oxygen through nasal cannula in acute hypoxemic respiratory failure. N Engl J Med 372:2185–2196. https://doi.org/10.1056/NEJMoa1503326CrossRefPubMed

86.

Nava S, Hill N (2009) Non-invasive ventilation in acute respiratory failure. Lancet (London, England) 374:250–259. https://doi.org/10.1016/S0140-6736(09)60496-7CrossRef

87.

Patel BK, Wolfe KS, Pohlman AS et al (2016) Effect of noninvasive ventilation delivered by helmet vs face mask on the rate of endotracheal intubation in patients with acute respiratory distress syndrome: a randomized clinical trial. JAMA 315:2435–2441. https://doi.org/10.1001/jama.2016.6338CrossRefPubMedPubMedCentral

88.

Sassoon CS, Light RW, Lodia R et al (1991) Pressure-time product during continuous positive airway pressure, pressure support ventilation, and T-piece during weaning from mechanical ventilation. Am Rev Respir Dis 143:469–475. https://doi.org/10.1164/ajrccm/143.3.469CrossRefPubMed

89.

Sassoon CS, Lodia R, Rheeman CH et al (1992) Inspiratory muscle work of breathing during flow-by, demand-flow, and continuous-flow systems in patients with chronic obstructive pulmonary disease. Am Rev Respir Dis 145:1219–1222. https://doi.org/10.1164/ajrccm/145.5.1219CrossRefPubMed

90.

Patroniti N, Foti G, Manfio A et al (2003) Head helmet versus face mask for non-invasive continuous positive airway pressure: a physiological study. Intensive Care Med 29:1680–1687. https://doi.org/10.1007/s00134-003-1931-8CrossRefPubMed

91.

Grieco DL, Biancone M, Maviglia R, Antonelli M (2015) A new strategy to deliver Helmet CPAP to critically ill patients: the possible role of ICU ventilators. Minerva Anestesiol 81:1144–1145PubMed

92.

Fraticelli AT, Lellouche F, L’her E et al (2009) Physiological effects of different interfaces during noninvasive ventilation for acute respiratory failure. Crit Care Med 37:939–945. https://doi.org/10.1097/CCM.0b013e31819b575fCrossRefPubMed

93.

MacIntyre NR (2019) Physiologic effects of noninvasive ventilation. Respir Care 64:617–628. https://doi.org/10.4187/respcare.06635CrossRefPubMed

94.

L’Her E, Deye N, Lellouche F et al (2005) Physiologic effects of noninvasive ventilation during acute lung injury. Am J Respir Crit Care Med 172:1112–1118. https://doi.org/10.1164/rccm.200402-226OCCrossRefPubMed

95.

Mehta S, Hill NS (2001) Noninvasive ventilation. Am J Respir Crit Care Med 163:540–577. https://doi.org/10.1164/ajrccm.163.2.9906116CrossRefPubMed

96.

Cabrini L, Landoni G, Oriani A et al (2015) Noninvasive ventilation and survival in acute care settings: a comprehensive systematic review and meta-analysis of randomized controlled trials. Crit Care Med 43:880–888. https://doi.org/10.1097/CCM.0000000000000819CrossRefPubMed

97.

Luce JM (1984) The cardiovascular effects of mechanical ventilation and positive end-expiratory pressure. JAMA 252:807–811. https://doi.org/10.1001/jama.1984.03350060051030CrossRefPubMed

98.

Luecke T, Pelosi P (2005) Clinical review: positive end-expiratory pressure and cardiac output. Crit Care 9:607–621. https://doi.org/10.1186/cc3877CrossRefPubMedPubMedCentral

99.

Lenique F, Habis M, Lofaso F et al (1997) Ventilatory and hemodynamic effects of continuous positive airway pressure in left heart failure. Am J Respir Crit Care Med 155:500–505. https://doi.org/10.1164/ajrccm.155.2.9032185CrossRefPubMed

100.

Delclaux C, L’Her E, Alberti C et al (2000) Treatment of acute hypoxemic nonhypercapnic respiratory insufficiency with continuous positive airway pressure delivered by a face mask: a randomized controlled trial. JAMA 284:2352–2360. https://doi.org/10.1001/jama.284.18.2352CrossRefPubMed

101.

Richard JCM, Lyazidi A, Akoumianaki E et al (2013) Potentially harmful effects of inspiratory synchronization during pressure preset ventilation. Intensive Care Med 39:2003–2010. https://doi.org/10.1007/s00134-013-3032-7CrossRefPubMed

102.

Rittayamai N, Beloncle F, Goligher EC et al (2017) Effect of inspiratory synchronization during pressure-controlled ventilation on lung distension and inspiratory effort. Ann Intensive Care 7:100. https://doi.org/10.1186/s13613-017-0324-zCrossRefPubMedPubMedCentral

103.

Gregoretti C, Confalonieri M, Navalesi P et al (2002) Evaluation of patient skin breakdown and comfort with a new face mask for non-invasive ventilation: a multi-center study. Intensive Care Med 28:278–284. https://doi.org/10.1007/s00134-002-1208-7CrossRefPubMed

104.

Schwartz AR, Kacmarek RM, Hess DR (2004) Factors affecting oxygen delivery with bi-level positive airway pressure. Respir Care 49:270–275PubMed

105.

Scandroglio M, Piccolo U, Mazzone E et al (2002) Use and nursing of the helmet in delivering non-invasive ventilation. Minerva Anestesiol 68:475–480PubMed

106.

Antonelli M, Conti G, Pelosi P et al (2002) New treatment of acute hypoxemic respiratory failure: noninvasive pressure support ventilation delivered by helmet—a pilot controlled trial. Crit Care Med 30:602–608. https://doi.org/10.1097/00003246-200203000-00019CrossRefPubMed

107.

Taccone P, Hess D, Caironi P, Bigatello LM (2004) Continuous positive airway pressure delivered with a “helmet”: effects on carbon dioxide rebreathing. Crit Care Med 32:2090–2096. https://doi.org/10.1097/01.ccm.0000142577.63316.c0CrossRefPubMed

108.

Mojoli F, Iotti GA, Currò I et al (2013) An optimized set-up for helmet noninvasive ventilation improves pressure support delivery and patient-ventilator interaction. Intensive Care Med 39:38–44. https://doi.org/10.1007/s00134-012-2686-xCrossRefPubMed

109.

Vargas F, Thille A, Lyazidi A et al (2009) Helmet with specific settings versus facemask for noninvasive ventilation. Crit Care Med 37:1921–1928. https://doi.org/10.1097/CCM.0b013e31819fff93CrossRefPubMed

110.

Chiumello D, Pelosi P, Carlesso E et al (2003) Noninvasive positive pressure ventilation delivered by helmet vs. standard face mask. Intensive Care Med 29:1671–1679. https://doi.org/10.1007/s00134-003-1825-9CrossRefPubMed

111.

Mojoli F, Iotti GA, Gerletti M et al (2008) Carbon dioxide rebreathing during non-invasive ventilation delivered by helmet: a bench study. Intensive Care Med 34:1454–1460. https://doi.org/10.1007/s00134-008-1109-5CrossRefPubMed

112.

Dianti J, Bertoni M, Goligher EC (2020) Monitoring patient-ventilator interaction by an end-expiratory occlusion maneuver. Intensive Care Med 46:2338–2341. https://doi.org/10.1007/s00134-020-06167-3CrossRefPubMed

113.

Tobin MJ, Laghi F, Jubran A (2020) Why COVID-19 silent hypoxemia is baffling to physicians. Am J Respir Crit Care Med 202:356–360. https://doi.org/10.1164/rccm.202006-2157CPCrossRefPubMedPubMedCentral

114.

Antonelli M, Conti G, Esquinas A et al (2007) A multiple-center survey on the use in clinical practice of noninvasive ventilation as a first-line intervention for acute respiratory distress syndrome. Crit Care Med 35:18–25. https://doi.org/10.1097/01.CCM.0000251821.44259.F3CrossRefPubMed

115.

Antonelli M, Conti G, Moro ML et al (2001) Predictors of failure of noninvasive positive pressure ventilation in patients with acute hypoxemic respiratory failure: a multi-center study. Intensive Care Med 27:1718–1728. https://doi.org/10.1007/s00134-001-1114-4CrossRefPubMed

116.

Akoumianaki E, Vaporidi K, Georgopoulos D (2019) The injurious effects of elevated or nonelevated respiratory rate during mechanical ventilation. Am J Respir Crit Care Med 199:149–157. https://doi.org/10.1164/rccm.201804-0726CICrossRefPubMed

117.

Yoshida Y, Takeda S, Akada S et al (2008) Factors predicting successful noninvasive ventilation in acute lung injury. J Anesth 22:201–206. https://doi.org/10.1007/s00540-008-0637-zCrossRefPubMed

118.

Duan J, Han X, Bai L et al (2017) Assessment of heart rate, acidosis, consciousness, oxygenation, and respiratory rate to predict noninvasive ventilation failure in hypoxemic patients. Intensive Care Med 43:192–199. https://doi.org/10.1007/s00134-016-4601-3CrossRefPubMed

119.

Cortegiani A, Navalesi P, Accurso G et al (2019) Tidal volume estimation during helmet noninvasive ventilation: an experimental feasibility study. Sci Rep 9:17324. https://doi.org/10.1038/s41598-019-54020-5CrossRefPubMedPubMedCentral

120.

Gattinoni L, Chiumello D, Caironi P et al (2020) COVID-19 pneumonia: different respiratory treatments for different phenotypes? Intensive Care Med 46:1099–1102. https://doi.org/10.1007/s00134-020-06033-2CrossRefPubMedPubMedCentral

121.

Teggia-Droghi M, Grassi A, Rezoagli E et al (2020) Comparison of two approaches to estimate driving pressure during assisted ventilation. Am J Respir Crit Care Med 202:1595–1598. https://doi.org/10.1164/rccm.202004-1281LECrossRefPubMed

122.

Confalonieri M, Potena A, Carbone G et al (1999) Acute respiratory failure in patients with severe community-acquired pneumonia. A prospective randomized evaluation of noninvasive ventilation. Am J Respir Crit Care Med 160(5 Pt 1):1585–1591. https://doi.org/10.1164/ajrccm.160.5.9903015CrossRefPubMed

123.

Martin TJ, Hovis JD, Costantino JP et al (2000) A randomized, prospective evaluation of noninvasive ventilation for acute respiratory failure. Am J Respir Crit Care Med 161(3 Pt 1):807–813. https://doi.org/10.1164/ajrccm.161.3.9808143CrossRefPubMed

124.

Hilbert G, Gruson D, Vargas F et al (2001) Noninvasive ventilation in immunosuppressed patients with pulmonary infiltrates, fever, and acute respiratory failure. N Engl J Med 344(7):481–487. https://doi.org/10.1056/NEJM200102153440703CrossRefPubMed

125.

Ferrer M, Esquinas A, Leon M et al (2003) Noninvasive ventilation in severe hypoxemic respiratory failure: a randomized clinical trial. Am J Respir Crit Care Med 168(12):1438–1444. https://doi.org/10.1164/rccm.200301-072OCCrossRefPubMed

126.

Gunduz M, Unlugenc H, Ozalevli M, Inanoglu K, Akman H (2005) A comparative study of continuous positive airway pressure (CPAP) and intermittent positive pressure ventilation (IPPV) in patients with flail chest. Emerg Med J 22(5):325–329. https://doi.org/10.1136/emj.2004.019786CrossRefPubMedPubMedCentral

127.

Hernandez G, Fernandez R, Lopez-Reina P et al (2010) Noninvasive ventilation reduces intubation in chest trauma-related hypoxemia: a randomized clinical trial. Chest 137(1):74–80. https://doi.org/10.1378/chest.09-1114CrossRefPubMed

128.

Wermke M, Schiemanck S, Höffken G et al (2012) Respiratory failure in patients undergoing allogeneic hematopoietic SCT—a randomized trial on early non-invasive ventilation based on standard care hematology wards. Bone Marrow Transplant 47(4):574–580. https://doi.org/10.1038/bmt.2011.160CrossRefPubMed

129.

Zhan Q, Sun B, Liang L et al (2012) Early use of noninvasive positive pressure ventilation for acute lung injury: a multicenter randomized controlled trial. Crit Care Med 40(2):455–460. https://doi.org/10.1097/CCM.0b013e318232d75eCrossRefPubMed

130.

Lemiale V, Mokart D, Resche-Rigon M et al (2015) Effect of noninvasive ventilation vs oxygen therapy on mortality among immunocompromised patients with acute respiratory failure: a randomized clinical trial. JAMA 314(16):1711–1719. https://doi.org/10.1001/jama.2015.12402CrossRefPubMed

131.

He H, Sun B, Liang L et al (2019) A multicenter RCT of noninvasive ventilation in pneumonia-induced early mild acute respiratory distress syndrome. Crit Care 23(1):300. https://doi.org/10.1186/s13054-019-2575-6CrossRefPubMedPubMedCentral

132.

Azevedo JR, Montenegro WS, Leitao AL et al (2015) High flow nasal cannula oxygen (hfnc) versus non-invasive positive pressure ventilation (nippv) in acute hypoxemic respiratory failure. A pilot randomized controlled trial. Intensive Care Med Exp 3(Suppl 1):A166. https://doi.org/10.1186/2197-425X-3-S1-A166CrossRefPubMedCentral

133.

Doshi P, Whittle JS, Bublewicz M et al (2018) High-velocity nasal insufflation in the treatment of respiratory failure: a randomized clinical trial. Ann Emerg Med 72(1):73.e5–83.e5. https://doi.org/10.1016/j.annemergmed.2017.12.006CrossRef

134.

Bell N, Hutchinson CL, Green TC et al (2015) Randomised control trial of humidified high flow nasal cannulae versus standard oxygen in the emergency department. Emerg Med Australas 27(6):537–541. https://doi.org/10.1111/1742-6723.12490CrossRefPubMed

135.

Jones PG, Kamona S, Doran O, Sawtell F, Wilsher M (2016) Randomized controlled trial of humidified high-flow nasal oxygen for acute respiratory distress in the emergency department: the HOT-ER study. Respir Care 61(3):291–299. https://doi.org/10.4187/respcare.04252CrossRefPubMed

136.

Azoulay E, Lemiale V, Mokart D et al (2018) Effect of high-flow nasal oxygen vs standard oxygen on 28-day mortality in immunocompromised patients with acute respiratory failure: the high randomized clinical trial. JAMA 320(20):2099–2107. https://doi.org/10.1001/jama.2018.14282CrossRefPubMedPubMedCentral

137.

Cosentini R, Brambilla AM, Aliberti S et al (2010) Helmet continuous positive airway pressure vs oxygen therapy to improve oxygenation in community-acquired pneumonia: a randomized, controlled trial. Chest 138(1):114–120. https://doi.org/10.1378/chest.09-2290CrossRefPubMed

138.

Squadrone V, Massaia M, Bruno B et al (2010) Early CPAP prevents evolution of acute lung injury in patients with hematologic malignancy. Intensive Care Med 36(10):1666–1674. https://doi.org/10.1007/s00134-010-1934-1CrossRefPubMed

139.

Brambilla AM, Aliberti S, Prina E et al (2014) Helmet CPAP vs. oxygen therapy in severe hypoxemic respiratory failure due to pneumonia. Intensive Care Med 40(7):942–949. https://doi.org/10.1007/s00134-014-3325-5CrossRefPubMed

Titel: Non-invasive ventilatory support and high-flow nasal oxygen as first-line treatment of acute hypoxemic respiratory failure and ARDS
verfasst von: Domenico Luca Grieco
Salvatore Maurizio Maggiore
Oriol Roca
Elena Spinelli
Bhakti K. Patel
Arnaud W. Thille
Carmen Sílvia V. Barbas
Marina Garcia de Acilu
Salvatore Lucio Cutuli
Filippo Bongiovanni
Marcelo Amato
Jean-Pierre Frat
Tommaso Mauri
John P. Kress
Jordi Mancebo
Massimo Antonelli
Publikationsdatum: 07.07.2021
Verlag: Springer Berlin Heidelberg
Erschienen in: Intensive Care Medicine / Ausgabe 8/2021
Print ISSN: 0342-4642
Elektronische ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-021-06459-2

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