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Erschienen in: Seminars in Immunopathology 3/2020

09.06.2020 | Review

Immunometabolism: new insights and lessons from antigen-directed cellular immune responses

verfasst von: Renata Ramalho, Martin Rao, Chao Zhang, Chiara Agrati, Giuseppe Ippolito, Fu-Sheng Wang, Alimuddin Zumla, Markus Maeurer

Erschienen in: Seminars in Immunopathology | Ausgabe 3/2020

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Abstract

Modulation of immune responses by nutrients is an important area of study in cellular biology and clinical sciences in the context of cancer therapies and anti-pathogen-directed immune responses in health and disease. We review metabolic pathways that influence immune cell function and cellular persistence in chronic infections. We also highlight the role of nutrients in altering the tissue microenvironment with lessons from the tumor microenvironment that shapes the quality and quantity of cellular immune responses. Multiple layers of biological networks, including the nature of nutritional supplements, the genetic background, previous exposures, and gut microbiota status have impact on cellular performance and immune competence against molecularly defined targets. We discuss how immune metabolism determines the differentiation pathway of antigen-specific immune cells and how these insights can be explored to devise better strategies to strengthen anti-pathogen-directed immune responses, while curbing unwanted, non-productive inflammation.
Literatur
21.
22.
Zurück zum Zitat Raud B, Roy DG, Divakaruni AS, Tarasenko TN, Franke R, Ma EH, Samborska B, Hsieh WY, Wong AH, Stuve P, Arnold-Schrauf C, Guderian M, Lochner M, Rampertaap S, Romito K, Monsale J, Bronstrup M, Bensinger SJ, Murphy AN, McGuire PJ, Jones RG, Sparwasser T, Berod L (2018) Etomoxir actions on regulatory and memory T cells are independent of Cpt1a-mediated fatty acid oxidation. Cell Metab 28(3):504–515.e507. https://doi.org/10.1016/j.cmet.2018.06.002 CrossRefPubMedPubMedCentral Raud B, Roy DG, Divakaruni AS, Tarasenko TN, Franke R, Ma EH, Samborska B, Hsieh WY, Wong AH, Stuve P, Arnold-Schrauf C, Guderian M, Lochner M, Rampertaap S, Romito K, Monsale J, Bronstrup M, Bensinger SJ, Murphy AN, McGuire PJ, Jones RG, Sparwasser T, Berod L (2018) Etomoxir actions on regulatory and memory T cells are independent of Cpt1a-mediated fatty acid oxidation. Cell Metab 28(3):504–515.e507. https://​doi.​org/​10.​1016/​j.​cmet.​2018.​06.​002 CrossRefPubMedPubMedCentral
32.
Zurück zum Zitat Cheng SC, Quintin J, Cramer RA, Shepardson KM, Saeed S, Kumar V, Giamarellos-Bourboulis EJ, Martens JH, Rao NA, Aghajanirefah A, Manjeri GR, Li Y, Ifrim DC, Arts RJ, van der Veer BM, Deen PM, Logie C, O’Neill LA, Willems P, van de Veerdonk FL, van der Meer JW, Ng A, Joosten LA, Wijmenga C, Stunnenberg HG, Xavier RJ, Netea MG (2014) mTOR- and HIF-1alpha-mediated aerobic glycolysis as metabolic basis for trained immunity. Science 345(6204):1250684. https://doi.org/10.1126/science.1250684 CrossRefPubMedPubMedCentral Cheng SC, Quintin J, Cramer RA, Shepardson KM, Saeed S, Kumar V, Giamarellos-Bourboulis EJ, Martens JH, Rao NA, Aghajanirefah A, Manjeri GR, Li Y, Ifrim DC, Arts RJ, van der Veer BM, Deen PM, Logie C, O’Neill LA, Willems P, van de Veerdonk FL, van der Meer JW, Ng A, Joosten LA, Wijmenga C, Stunnenberg HG, Xavier RJ, Netea MG (2014) mTOR- and HIF-1alpha-mediated aerobic glycolysis as metabolic basis for trained immunity. Science 345(6204):1250684. https://​doi.​org/​10.​1126/​science.​1250684 CrossRefPubMedPubMedCentral
38.
Zurück zum Zitat Palsson-McDermott EM, Curtis AM, Goel G, Lauterbach MA, Sheedy FJ, Gleeson LE, van den Bosch MW, Quinn SR, Domingo-Fernandez R, Johnston DG, Jiang JK, Israelsen WJ, Keane J, Thomas C, Clish C, Vander Heiden M, Xavier RJ, O’Neill LA (2015) Pyruvate kinase M2 regulates Hif-1alpha activity and IL-1beta induction and is a critical determinant of the Warburg effect in LPS-activated macrophages. Cell Metab 21(1):65–80. https://doi.org/10.1016/j.cmet.2014.12.005 CrossRefPubMedPubMedCentral Palsson-McDermott EM, Curtis AM, Goel G, Lauterbach MA, Sheedy FJ, Gleeson LE, van den Bosch MW, Quinn SR, Domingo-Fernandez R, Johnston DG, Jiang JK, Israelsen WJ, Keane J, Thomas C, Clish C, Vander Heiden M, Xavier RJ, O’Neill LA (2015) Pyruvate kinase M2 regulates Hif-1alpha activity and IL-1beta induction and is a critical determinant of the Warburg effect in LPS-activated macrophages. Cell Metab 21(1):65–80. https://​doi.​org/​10.​1016/​j.​cmet.​2014.​12.​005 CrossRefPubMedPubMedCentral
43.
Zurück zum Zitat Stincone A, Prigione A, Cramer T, Wamelink MM, Campbell K, Cheung E, Olin-Sandoval V, Gruning NM, Kruger A, Tauqeer Alam M, Keller MA, Breitenbach M, Brindle KM, Rabinowitz JD, Ralser M (2015) The return of metabolism: biochemistry and physiology of the pentose phosphate pathway. Biol Rev Camb Philos Soc 90(3):927–963. https://doi.org/10.1111/brv.12140 CrossRefPubMed Stincone A, Prigione A, Cramer T, Wamelink MM, Campbell K, Cheung E, Olin-Sandoval V, Gruning NM, Kruger A, Tauqeer Alam M, Keller MA, Breitenbach M, Brindle KM, Rabinowitz JD, Ralser M (2015) The return of metabolism: biochemistry and physiology of the pentose phosphate pathway. Biol Rev Camb Philos Soc 90(3):927–963. https://​doi.​org/​10.​1111/​brv.​12140 CrossRefPubMed
47.
Zurück zum Zitat Berod L, Friedrich C, Nandan A, Freitag J, Hagemann S, Harmrolfs K, Sandouk A, Hesse C, Castro CN, Bahre H, Tschirner SK, Gorinski N, Gohmert M, Mayer CT, Huehn J, Ponimaskin E, Abraham WR, Muller R, Lochner M, Sparwasser T (2014) De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells. Nat Med 20(11):1327–1333. https://doi.org/10.1038/nm.3704 CrossRefPubMed Berod L, Friedrich C, Nandan A, Freitag J, Hagemann S, Harmrolfs K, Sandouk A, Hesse C, Castro CN, Bahre H, Tschirner SK, Gorinski N, Gohmert M, Mayer CT, Huehn J, Ponimaskin E, Abraham WR, Muller R, Lochner M, Sparwasser T (2014) De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells. Nat Med 20(11):1327–1333. https://​doi.​org/​10.​1038/​nm.​3704 CrossRefPubMed
73.
Zurück zum Zitat Jha AK, Huang SC, Sergushichev A, Lampropoulou V, Ivanova Y, Loginicheva E, Chmielewski K, Stewart KM, Ashall J, Everts B, Pearce EJ, Driggers EM, Artyomov MN (2015) Network integration of parallel metabolic and transcriptional data reveals metabolic modules that regulate macrophage polarization. Immunity 42(3):419–430. https://doi.org/10.1016/j.immuni.2015.02.005 CrossRefPubMed Jha AK, Huang SC, Sergushichev A, Lampropoulou V, Ivanova Y, Loginicheva E, Chmielewski K, Stewart KM, Ashall J, Everts B, Pearce EJ, Driggers EM, Artyomov MN (2015) Network integration of parallel metabolic and transcriptional data reveals metabolic modules that regulate macrophage polarization. Immunity 42(3):419–430. https://​doi.​org/​10.​1016/​j.​immuni.​2015.​02.​005 CrossRefPubMed
85.
Zurück zum Zitat Lirk P, Hoffmann G, Rieder J (2002) Inducible nitric oxide synthase—time for reappraisal. Curr Drug Targets Inflamm Allergy 1(1):89–108CrossRefPubMed Lirk P, Hoffmann G, Rieder J (2002) Inducible nitric oxide synthase—time for reappraisal. Curr Drug Targets Inflamm Allergy 1(1):89–108CrossRefPubMed
97.
Zurück zum Zitat Caro-Maldonado A, Wang R, Nichols AG, Kuraoka M, Milasta S, Sun LD, Gavin AL, Abel ED, Kelsoe G, Green DR, Rathmell JC (2014) Metabolic reprogramming is required for antibody production that is suppressed in anergic but exaggerated in chronically BAFF-exposed B cells. J Immunol 192(8):3626–3636. https://doi.org/10.4049/jimmunol.1302062 CrossRefPubMed Caro-Maldonado A, Wang R, Nichols AG, Kuraoka M, Milasta S, Sun LD, Gavin AL, Abel ED, Kelsoe G, Green DR, Rathmell JC (2014) Metabolic reprogramming is required for antibody production that is suppressed in anergic but exaggerated in chronically BAFF-exposed B cells. J Immunol 192(8):3626–3636. https://​doi.​org/​10.​4049/​jimmunol.​1302062 CrossRefPubMed
101.
Zurück zum Zitat Jantsch J, Chakravortty D, Turza N, Prechtel AT, Buchholz B, Gerlach RG, Volke M, Glasner J, Warnecke C, Wiesener MS, Eckardt KU, Steinkasserer A, Hensel M, Willam C (2008) Hypoxia and hypoxia-inducible factor-1 alpha modulate lipopolysaccharide-induced dendritic cell activation and function. J Immunol 180(7):4697–4705. https://doi.org/10.4049/jimmunol.180.7.4697 CrossRefPubMed Jantsch J, Chakravortty D, Turza N, Prechtel AT, Buchholz B, Gerlach RG, Volke M, Glasner J, Warnecke C, Wiesener MS, Eckardt KU, Steinkasserer A, Hensel M, Willam C (2008) Hypoxia and hypoxia-inducible factor-1 alpha modulate lipopolysaccharide-induced dendritic cell activation and function. J Immunol 180(7):4697–4705. https://​doi.​org/​10.​4049/​jimmunol.​180.​7.​4697 CrossRefPubMed
104.
Zurück zum Zitat Everts B, Amiel E, Huang SC, Smith AM, Chang CH, Lam WY, Redmann V, Freitas TC, Blagih J, van der Windt GJ, Artyomov MN, Jones RG, Pearce EL, Pearce EJ (2014) TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKvarepsilon supports the anabolic demands of dendritic cell activation. Nat Immunol 15(4):323–332. https://doi.org/10.1038/ni.2833 CrossRefPubMedPubMedCentral Everts B, Amiel E, Huang SC, Smith AM, Chang CH, Lam WY, Redmann V, Freitas TC, Blagih J, van der Windt GJ, Artyomov MN, Jones RG, Pearce EL, Pearce EJ (2014) TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKvarepsilon supports the anabolic demands of dendritic cell activation. Nat Immunol 15(4):323–332. https://​doi.​org/​10.​1038/​ni.​2833 CrossRefPubMedPubMedCentral
107.
Zurück zum Zitat Mondanelli G, Bianchi R, Pallotta MT, Orabona C, Albini E, Iacono A, Belladonna ML, Vacca C, Fallarino F, Macchiarulo A, Ugel S, Bronte V, Gevi F, Zolla L, Verhaar A, Peppelenbosch M, Mazza EMC, Bicciato S, Laouar Y, Santambrogio L, Puccetti P, Volpi C, Grohmann U (2017) A relay pathway between arginine and tryptophan metabolism confers immunosuppressive properties on dendritic cells. Immunity 46(2):233–244. https://doi.org/10.1016/j.immuni.2017.01.005 CrossRefPubMedPubMedCentral Mondanelli G, Bianchi R, Pallotta MT, Orabona C, Albini E, Iacono A, Belladonna ML, Vacca C, Fallarino F, Macchiarulo A, Ugel S, Bronte V, Gevi F, Zolla L, Verhaar A, Peppelenbosch M, Mazza EMC, Bicciato S, Laouar Y, Santambrogio L, Puccetti P, Volpi C, Grohmann U (2017) A relay pathway between arginine and tryptophan metabolism confers immunosuppressive properties on dendritic cells. Immunity 46(2):233–244. https://​doi.​org/​10.​1016/​j.​immuni.​2017.​01.​005 CrossRefPubMedPubMedCentral
109.
Zurück zum Zitat Cascone T, McKenzie JA, Mbofung RM, Punt S, Wang Z, Xu C, Williams LJ, Wang Z, Bristow CA, Carugo A, Peoples MD, Li L, Karpinets T, Huang L, Malu S, Creasy C, Leahey SE, Chen J, Chen Y, Pelicano H, Bernatchez C, Gopal YNV, Heffernan TP, Hu J, Wang J, Amaria RN, Garraway LA, Huang P, Yang P, Wistuba II, Woodman SE, Roszik J, Davis RE, Davies MA, Heymach JV, Hwu P, Peng W (2018) Increased tumor glycolysis characterizes immune resistance to adoptive T cell therapy. Cell Metab 27(5):977–987.e974. https://doi.org/10.1016/j.cmet.2018.02.024 CrossRefPubMedPubMedCentral Cascone T, McKenzie JA, Mbofung RM, Punt S, Wang Z, Xu C, Williams LJ, Wang Z, Bristow CA, Carugo A, Peoples MD, Li L, Karpinets T, Huang L, Malu S, Creasy C, Leahey SE, Chen J, Chen Y, Pelicano H, Bernatchez C, Gopal YNV, Heffernan TP, Hu J, Wang J, Amaria RN, Garraway LA, Huang P, Yang P, Wistuba II, Woodman SE, Roszik J, Davis RE, Davies MA, Heymach JV, Hwu P, Peng W (2018) Increased tumor glycolysis characterizes immune resistance to adoptive T cell therapy. Cell Metab 27(5):977–987.e974. https://​doi.​org/​10.​1016/​j.​cmet.​2018.​02.​024 CrossRefPubMedPubMedCentral
117.
121.
127.
Zurück zum Zitat Brown RS, Wahl RL (1993) Overexpression of Glut-1 glucose transporter in human breast cancer. An immunohistochemical study. Cancer 72(10):2979–2985CrossRefPubMed Brown RS, Wahl RL (1993) Overexpression of Glut-1 glucose transporter in human breast cancer. An immunohistochemical study. Cancer 72(10):2979–2985CrossRefPubMed
128.
Zurück zum Zitat Canpolat T, Ersoz C, Uguz A, Vardar MA, Altintas A (2016) GLUT-1 expression in proliferative endometrium, endometrial hyperplasia, endometrial adenocarcinoma and the relationship between GLUT-1 expression and prognostic parameters in endometrial adenocarcinoma. Turk Patoloji Derg 32(3):141–147. https://doi.org/10.5146/tjpath.2015.01352 CrossRefPubMed Canpolat T, Ersoz C, Uguz A, Vardar MA, Altintas A (2016) GLUT-1 expression in proliferative endometrium, endometrial hyperplasia, endometrial adenocarcinoma and the relationship between GLUT-1 expression and prognostic parameters in endometrial adenocarcinoma. Turk Patoloji Derg 32(3):141–147. https://​doi.​org/​10.​5146/​tjpath.​2015.​01352 CrossRefPubMed
133.
Zurück zum Zitat Boros LG, Torday JS, Lim S, Bassilian S, Cascante M, Lee WN (2000) Transforming growth factor beta2 promotes glucose carbon incorporation into nucleic acid ribose through the nonoxidative pentose cycle in lung epithelial carcinoma cells. Cancer Res 60(5):1183–1185PubMed Boros LG, Torday JS, Lim S, Bassilian S, Cascante M, Lee WN (2000) Transforming growth factor beta2 promotes glucose carbon incorporation into nucleic acid ribose through the nonoxidative pentose cycle in lung epithelial carcinoma cells. Cancer Res 60(5):1183–1185PubMed
138.
140.
Zurück zum Zitat Kumar V, Donthireddy L, Marvel D, Condamine T, Wang F, Lavilla-Alonso S, Hashimoto A, Vonteddu P, Behera R, Goins MA, Mulligan C, Nam B, Hockstein N, Denstman F, Shakamuri S, Speicher DW, Weeraratna AT, Chao T, Vonderheide RH, Languino LR, Ordentlich P, Liu Q, Xu X, Lo A, Pure E, Zhang C, Loboda A, Sepulveda MA, Snyder LA, Gabrilovich DI (2017) Cancer-associated fibroblasts neutralize the anti-tumor effect of CSF1 receptor blockade by inducing PMN-MDSC infiltration of tumors. Cancer Cell 32(5):654–668.e655. https://doi.org/10.1016/j.ccell.2017.10.005 CrossRefPubMedPubMedCentral Kumar V, Donthireddy L, Marvel D, Condamine T, Wang F, Lavilla-Alonso S, Hashimoto A, Vonteddu P, Behera R, Goins MA, Mulligan C, Nam B, Hockstein N, Denstman F, Shakamuri S, Speicher DW, Weeraratna AT, Chao T, Vonderheide RH, Languino LR, Ordentlich P, Liu Q, Xu X, Lo A, Pure E, Zhang C, Loboda A, Sepulveda MA, Snyder LA, Gabrilovich DI (2017) Cancer-associated fibroblasts neutralize the anti-tumor effect of CSF1 receptor blockade by inducing PMN-MDSC infiltration of tumors. Cancer Cell 32(5):654–668.e655. https://​doi.​org/​10.​1016/​j.​ccell.​2017.​10.​005 CrossRefPubMedPubMedCentral
141.
Zurück zum Zitat Hendry S, Salgado R, Gevaert T, Russell PA, John T, Thapa B, Christie M, van de Vijver K, Estrada MV, Gonzalez-Ericsson PI, Sanders M, Solomon B, Solinas C, Van den Eynden G, Allory Y, Preusser M, Hainfellner J, Pruneri G, Vingiani A, Demaria S, Symmans F, Nuciforo P, Comerma L, Thompson EA, Lakhani S, Kim SR, Schnitt S, Colpaert C, Sotiriou C, Scherer SJ, Ignatiadis M, Badve S, Pierce RH, Viale G, Sirtaine N, Penault-Llorca F, Sugie T, Fineberg S, Paik S, Srinivasan A, Richardson A, Wang Y, Chmielik E, Brock J, Johnson DB, Balko J, Wienert S, Bossuyt V, Michiels S, Ternes N, Burchardi N, Luen SJ, Savas P, Klauschen F, Watson PH, Nelson BH, Criscitiello C, O’Toole S, Larsimont D, de Wind R, Curigliano G, Andre F, Lacroix-Triki M, van de Vijver M, Rojo F, Floris G, Bedri S, Sparano J, Rimm D, Nielsen T, Kos Z, Hewitt S, Singh B, Farshid G, Loibl S, Allison KH, Tung N, Adams S, Willard-Gallo K, Horlings HM, Gandhi L, Moreira A, Hirsch F, Dieci MV, Urbanowicz M, Brcic I, Korski K, Gaire F, Koeppen H, Lo A, Giltnane J, Rebelatto MC, Steele KE, Zha J, Emancipator K, Juco JW, Denkert C, Reis-Filho J, Loi S, Fox SB (2017) Assessing tumor-infiltrating lymphocytes in solid tumors: a practical review for pathologists and proposal for a standardized method from the international immuno-oncology biomarkers working group: part 2: TILs in melanoma, gastrointestinal tract carcinomas, non-small cell lung carcinoma and mesothelioma, endometrial and ovarian carcinomas, squamous cell carcinoma of the head and neck, genitourinary carcinomas, and primary brain tumors. Adv Anat Pathol. https://doi.org/10.1097/PAP.0000000000000161 Hendry S, Salgado R, Gevaert T, Russell PA, John T, Thapa B, Christie M, van de Vijver K, Estrada MV, Gonzalez-Ericsson PI, Sanders M, Solomon B, Solinas C, Van den Eynden G, Allory Y, Preusser M, Hainfellner J, Pruneri G, Vingiani A, Demaria S, Symmans F, Nuciforo P, Comerma L, Thompson EA, Lakhani S, Kim SR, Schnitt S, Colpaert C, Sotiriou C, Scherer SJ, Ignatiadis M, Badve S, Pierce RH, Viale G, Sirtaine N, Penault-Llorca F, Sugie T, Fineberg S, Paik S, Srinivasan A, Richardson A, Wang Y, Chmielik E, Brock J, Johnson DB, Balko J, Wienert S, Bossuyt V, Michiels S, Ternes N, Burchardi N, Luen SJ, Savas P, Klauschen F, Watson PH, Nelson BH, Criscitiello C, O’Toole S, Larsimont D, de Wind R, Curigliano G, Andre F, Lacroix-Triki M, van de Vijver M, Rojo F, Floris G, Bedri S, Sparano J, Rimm D, Nielsen T, Kos Z, Hewitt S, Singh B, Farshid G, Loibl S, Allison KH, Tung N, Adams S, Willard-Gallo K, Horlings HM, Gandhi L, Moreira A, Hirsch F, Dieci MV, Urbanowicz M, Brcic I, Korski K, Gaire F, Koeppen H, Lo A, Giltnane J, Rebelatto MC, Steele KE, Zha J, Emancipator K, Juco JW, Denkert C, Reis-Filho J, Loi S, Fox SB (2017) Assessing tumor-infiltrating lymphocytes in solid tumors: a practical review for pathologists and proposal for a standardized method from the international immuno-oncology biomarkers working group: part 2: TILs in melanoma, gastrointestinal tract carcinomas, non-small cell lung carcinoma and mesothelioma, endometrial and ovarian carcinomas, squamous cell carcinoma of the head and neck, genitourinary carcinomas, and primary brain tumors. Adv Anat Pathol. https://​doi.​org/​10.​1097/​PAP.​0000000000000161​
149.
Zurück zum Zitat Patsoukis N, Bardhan K, Chatterjee P, Sari D, Liu B, Bell LN, Karoly ED, Freeman GJ, Petkova V, Seth P, Li L, Boussiotis VA (2015) PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation. Nat Commun 6:6692–6692. https://doi.org/10.1038/ncomms7692 CrossRefPubMed Patsoukis N, Bardhan K, Chatterjee P, Sari D, Liu B, Bell LN, Karoly ED, Freeman GJ, Petkova V, Seth P, Li L, Boussiotis VA (2015) PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation. Nat Commun 6:6692–6692. https://​doi.​org/​10.​1038/​ncomms7692 CrossRefPubMed
169.
188.
Zurück zum Zitat Scrimshaw NS, Taylor CE, Gordon JE (1959) Interactions of nutrition and infection. Am J Med Sci 237(3):367–403PubMed Scrimshaw NS, Taylor CE, Gordon JE (1959) Interactions of nutrition and infection. Am J Med Sci 237(3):367–403PubMed
189.
Zurück zum Zitat Scrimshaw NS, Taylor CE, Gordon JE (1969) Interactions of nutrition and infection. WHO Chron 23(8):369–374PubMed Scrimshaw NS, Taylor CE, Gordon JE (1969) Interactions of nutrition and infection. WHO Chron 23(8):369–374PubMed
190.
Zurück zum Zitat Scrimshaw NS (1966) Synergistic and antagonistic interactions of nutrition and infection. Fed Proc 25(6):1679–1681PubMed Scrimshaw NS (1966) Synergistic and antagonistic interactions of nutrition and infection. Fed Proc 25(6):1679–1681PubMed
207.
Zurück zum Zitat Takikawa A, Mahmood A, Nawaz A, Kado T, Okabe K, Yamamoto S, Aminuddin A, Senda S, Tsuneyama K, Ikutani M, Watanabe Y, Igarashi Y, Nagai Y, Takatsu K, Koizumi K, Imura J, Goda N, Sasahara M, Matsumoto M, Saeki K, Nakagawa T, Fujisaka S, Usui I, Tobe K (2016) HIF-1alpha in myeloid cells promotes adipose tissue remodeling toward insulin resistance. Diabetes 65(12):3649–3659. https://doi.org/10.2337/db16-0012 CrossRefPubMed Takikawa A, Mahmood A, Nawaz A, Kado T, Okabe K, Yamamoto S, Aminuddin A, Senda S, Tsuneyama K, Ikutani M, Watanabe Y, Igarashi Y, Nagai Y, Takatsu K, Koizumi K, Imura J, Goda N, Sasahara M, Matsumoto M, Saeki K, Nakagawa T, Fujisaka S, Usui I, Tobe K (2016) HIF-1alpha in myeloid cells promotes adipose tissue remodeling toward insulin resistance. Diabetes 65(12):3649–3659. https://​doi.​org/​10.​2337/​db16-0012 CrossRefPubMed
210.
212.
218.
Zurück zum Zitat Cespedes Feliciano EM, Lee VS, Prado CM, Meyerhardt JA, Alexeeff S, Kroenke CH, Xiao J, Castillo AL, Caan BJ (2017) Muscle mass at the time of diagnosis of nonmetastatic colon cancer and early discontinuation of chemotherapy, delays, and dose reductions on adjuvant FOLFOX: the C-SCANS study. Cancer 123(24):4868–4877. https://doi.org/10.1002/cncr.30950 CrossRefPubMed Cespedes Feliciano EM, Lee VS, Prado CM, Meyerhardt JA, Alexeeff S, Kroenke CH, Xiao J, Castillo AL, Caan BJ (2017) Muscle mass at the time of diagnosis of nonmetastatic colon cancer and early discontinuation of chemotherapy, delays, and dose reductions on adjuvant FOLFOX: the C-SCANS study. Cancer 123(24):4868–4877. https://​doi.​org/​10.​1002/​cncr.​30950 CrossRefPubMed
232.
234.
Zurück zum Zitat Tappenden KA, Quatrara B, Parkhurst ML, Malone AM, Fanjiang G, Ziegler TR (2013) Critical role of nutrition in improving quality of care: an interdisciplinary call to action to address adult hospital malnutrition. Medsurg Nurs 22(3):147–165PubMed Tappenden KA, Quatrara B, Parkhurst ML, Malone AM, Fanjiang G, Ziegler TR (2013) Critical role of nutrition in improving quality of care: an interdisciplinary call to action to address adult hospital malnutrition. Medsurg Nurs 22(3):147–165PubMed
235.
Zurück zum Zitat Arends J, Baracos V, Bertz H, Bozzetti F, Calder PC, Deutz NEP, Erickson N, Laviano A, Lisanti MP, Lobo DN, McMillan DC, Muscaritoli M, Ockenga J, Pirlich M, Strasser F, de van der Schueren M, Van Gossum A, Vaupel P, Weimann A (2017) ESPEN expert group recommendations for action against cancer-related malnutrition. Clin Nutr 36(5):1187–1196. https://doi.org/10.1016/j.clnu.2017.06.017 CrossRefPubMed Arends J, Baracos V, Bertz H, Bozzetti F, Calder PC, Deutz NEP, Erickson N, Laviano A, Lisanti MP, Lobo DN, McMillan DC, Muscaritoli M, Ockenga J, Pirlich M, Strasser F, de van der Schueren M, Van Gossum A, Vaupel P, Weimann A (2017) ESPEN expert group recommendations for action against cancer-related malnutrition. Clin Nutr 36(5):1187–1196. https://​doi.​org/​10.​1016/​j.​clnu.​2017.​06.​017 CrossRefPubMed
237.
Zurück zum Zitat Fukuda Y, Yamamoto K, Hirao M, Nishikawa K, Maeda S, Haraguchi N, Miyake M, Hama N, Miyamoto A, Ikeda M, Nakamori S, Sekimoto M, Fujitani K, Tsujinaka T (2015) Prevalence of malnutrition among gastric cancer patients undergoing gastrectomy and optimal preoperative nutritional support for preventing surgical site infections. Ann Surg Oncol 22(Suppl 3):S778–S785. https://doi.org/10.1245/s10434-015-4820-9 CrossRefPubMed Fukuda Y, Yamamoto K, Hirao M, Nishikawa K, Maeda S, Haraguchi N, Miyake M, Hama N, Miyamoto A, Ikeda M, Nakamori S, Sekimoto M, Fujitani K, Tsujinaka T (2015) Prevalence of malnutrition among gastric cancer patients undergoing gastrectomy and optimal preoperative nutritional support for preventing surgical site infections. Ann Surg Oncol 22(Suppl 3):S778–S785. https://​doi.​org/​10.​1245/​s10434-015-4820-9 CrossRefPubMed
238.
Zurück zum Zitat Kang MC, Kim JH, Ryu SW, Moon JY, Park JH, Park JK, Park JH, Baik HW, Seo JM, Son MW, Song GA, Shin DW, Shin YM, Ahn HY, Yang HK, Yu HC, Yun IJ, Lee JG, Lee JM, Lee JH, Lee TH, Yim H, Jeon HJ, Jung K, Jung MR, Jeong CY, Lim HS, Hong SK (2018) Prevalence of malnutrition in hospitalized patients: a multicenter cross-sectional study. J Korean Med Sci 33(2):e10. https://doi.org/10.3346/jkms.2018.33.e10 CrossRefPubMed Kang MC, Kim JH, Ryu SW, Moon JY, Park JH, Park JK, Park JH, Baik HW, Seo JM, Son MW, Song GA, Shin DW, Shin YM, Ahn HY, Yang HK, Yu HC, Yun IJ, Lee JG, Lee JM, Lee JH, Lee TH, Yim H, Jeon HJ, Jung K, Jung MR, Jeong CY, Lim HS, Hong SK (2018) Prevalence of malnutrition in hospitalized patients: a multicenter cross-sectional study. J Korean Med Sci 33(2):e10. https://​doi.​org/​10.​3346/​jkms.​2018.​33.​e10 CrossRefPubMed
242.
Zurück zum Zitat Routy B, Le Chatelier E, Derosa L, Duong CPM, Alou MT, Daillere R, Fluckiger A, Messaoudene M, Rauber C, Roberti MP, Fidelle M, Flament C, Poirier-Colame V, Opolon P, Klein C, Iribarren K, Mondragon L, Jacquelot N, Qu B, Ferrere G, Clemenson C, Mezquita L, Masip JR, Naltet C, Brosseau S, Kaderbhai C, Richard C, Rizvi H, Levenez F, Galleron N, Quinquis B, Pons N, Ryffel B, Minard-Colin V, Gonin P, Soria JC, Deutsch E, Loriot Y, Ghiringhelli F, Zalcman G, Goldwasser F, Escudier B, Hellmann MD, Eggermont A, Raoult D, Albiges L, Kroemer G, Zitvogel L (2018) Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors. Science 359(6371):91–97. https://doi.org/10.1126/science.aan3706 CrossRefPubMed Routy B, Le Chatelier E, Derosa L, Duong CPM, Alou MT, Daillere R, Fluckiger A, Messaoudene M, Rauber C, Roberti MP, Fidelle M, Flament C, Poirier-Colame V, Opolon P, Klein C, Iribarren K, Mondragon L, Jacquelot N, Qu B, Ferrere G, Clemenson C, Mezquita L, Masip JR, Naltet C, Brosseau S, Kaderbhai C, Richard C, Rizvi H, Levenez F, Galleron N, Quinquis B, Pons N, Ryffel B, Minard-Colin V, Gonin P, Soria JC, Deutsch E, Loriot Y, Ghiringhelli F, Zalcman G, Goldwasser F, Escudier B, Hellmann MD, Eggermont A, Raoult D, Albiges L, Kroemer G, Zitvogel L (2018) Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors. Science 359(6371):91–97. https://​doi.​org/​10.​1126/​science.​aan3706 CrossRefPubMed
243.
Zurück zum Zitat Wirbel J, Pyl PT, Kartal E, Zych K, Kashani A, Milanese A, Fleck JS, Voigt AY, Palleja A, Ponnudurai R, Sunagawa S, Coelho LP, Schrotz-King P, Vogtmann E, Habermann N, Nimeus E, Thomas AM, Manghi P, Gandini S, Serrano D, Mizutani S, Shiroma H, Shiba S, Shibata T, Yachida S, Yamada T, Waldron L, Naccarati A, Segata N, Sinha R, Ulrich CM, Brenner H, Arumugam M, Bork P, Zeller G (2019) Meta-analysis of fecal metagenomes reveals global microbial signatures that are specific for colorectal cancer. Nat Med 25(4):679–689. https://doi.org/10.1038/s41591-019-0406-6 CrossRefPubMedPubMedCentral Wirbel J, Pyl PT, Kartal E, Zych K, Kashani A, Milanese A, Fleck JS, Voigt AY, Palleja A, Ponnudurai R, Sunagawa S, Coelho LP, Schrotz-King P, Vogtmann E, Habermann N, Nimeus E, Thomas AM, Manghi P, Gandini S, Serrano D, Mizutani S, Shiroma H, Shiba S, Shibata T, Yachida S, Yamada T, Waldron L, Naccarati A, Segata N, Sinha R, Ulrich CM, Brenner H, Arumugam M, Bork P, Zeller G (2019) Meta-analysis of fecal metagenomes reveals global microbial signatures that are specific for colorectal cancer. Nat Med 25(4):679–689. https://​doi.​org/​10.​1038/​s41591-019-0406-6 CrossRefPubMedPubMedCentral
254.
Zurück zum Zitat Claesson MJ, Cusack S, O’Sullivan O, Greene-Diniz R, de Weerd H, Flannery E, Marchesi JR, Falush D, Dinan T, Fitzgerald G, Stanton C, van Sinderen D, O’Connor M, Harnedy N, O’Connor K, Henry C, O’Mahony D, Fitzgerald AP, Shanahan F, Twomey C, Hill C, Ross RP, O’Toole PW (2011) Composition, variability, and temporal stability of the intestinal microbiota of the elderly. Proc Natl Acad Sci U S A 108(Suppl 1):4586–4591. https://doi.org/10.1073/pnas.1000097107 CrossRefPubMed Claesson MJ, Cusack S, O’Sullivan O, Greene-Diniz R, de Weerd H, Flannery E, Marchesi JR, Falush D, Dinan T, Fitzgerald G, Stanton C, van Sinderen D, O’Connor M, Harnedy N, O’Connor K, Henry C, O’Mahony D, Fitzgerald AP, Shanahan F, Twomey C, Hill C, Ross RP, O’Toole PW (2011) Composition, variability, and temporal stability of the intestinal microbiota of the elderly. Proc Natl Acad Sci U S A 108(Suppl 1):4586–4591. https://​doi.​org/​10.​1073/​pnas.​1000097107 CrossRefPubMed
255.
Zurück zum Zitat Claesson MJ, Jeffery IB, Conde S, Power SE, O’Connor EM, Cusack S, Harris HM, Coakley M, Lakshminarayanan B, O’Sullivan O, Fitzgerald GF, Deane J, O’Connor M, Harnedy N, O’Connor K, O’Mahony D, van Sinderen D, Wallace M, Brennan L, Stanton C, Marchesi JR, Fitzgerald AP, Shanahan F, Hill C, Ross RP, O’Toole PW (2012) Gut microbiota composition correlates with diet and health in the elderly. Nature 488(7410):178–184. https://doi.org/10.1038/nature11319 CrossRefPubMed Claesson MJ, Jeffery IB, Conde S, Power SE, O’Connor EM, Cusack S, Harris HM, Coakley M, Lakshminarayanan B, O’Sullivan O, Fitzgerald GF, Deane J, O’Connor M, Harnedy N, O’Connor K, O’Mahony D, van Sinderen D, Wallace M, Brennan L, Stanton C, Marchesi JR, Fitzgerald AP, Shanahan F, Hill C, Ross RP, O’Toole PW (2012) Gut microbiota composition correlates with diet and health in the elderly. Nature 488(7410):178–184. https://​doi.​org/​10.​1038/​nature11319 CrossRefPubMed
259.
Zurück zum Zitat Bibbo S, Ianiro G, Giorgio V, Scaldaferri F, Masucci L, Gasbarrini A, Cammarota G (2016) The role of diet on gut microbiota composition. Eur Rev Med Pharmacol Sci 20(22):4742–4749PubMed Bibbo S, Ianiro G, Giorgio V, Scaldaferri F, Masucci L, Gasbarrini A, Cammarota G (2016) The role of diet on gut microbiota composition. Eur Rev Med Pharmacol Sci 20(22):4742–4749PubMed
264.
271.
Zurück zum Zitat Yoshimura T, McLean MH, Dzutsev AK, Yao X, Chen K, Huang J, Gong W, Zhou J, Xiang Y, J HB, O’Huigin C, Thovarai V, Tessarollo L, Durum SK, Trinchieri G, Bian XW, Wang JM (2018) The antimicrobial peptide CRAMP is essential for colon homeostasis by maintaining microbiota balance. J Immunol 200(6):2174–2185. https://doi.org/10.4049/jimmunol.1602073 CrossRefPubMed Yoshimura T, McLean MH, Dzutsev AK, Yao X, Chen K, Huang J, Gong W, Zhou J, Xiang Y, J HB, O’Huigin C, Thovarai V, Tessarollo L, Durum SK, Trinchieri G, Bian XW, Wang JM (2018) The antimicrobial peptide CRAMP is essential for colon homeostasis by maintaining microbiota balance. J Immunol 200(6):2174–2185. https://​doi.​org/​10.​4049/​jimmunol.​1602073 CrossRefPubMed
273.
Zurück zum Zitat Bacher P, Hohnstein T, Beerbaum E, Rocker M, Blango MG, Kaufmann S, Rohmel J, Eschenhagen P, Grehn C, Seidel K, Rickerts V, Lozza L, Stervbo U, Nienen M, Babel N, Milleck J, Assenmacher M, Cornely OA, Ziegler M, Wisplinghoff H, Heine G, Worm M, Siegmund B, Maul J, Creutz P, Tabeling C, Ruwwe-Glosenkamp C, Sander LE, Knosalla C, Brunke S, Hube B, Kniemeyer O, Brakhage AA, Schwarz C, Scheffold A (2019) Human anti-fungal Th17 immunity and pathology rely on cross-reactivity against Candida albicans. Cell 176(6):1340–1355.e1315. https://doi.org/10.1016/j.cell.2019.01.041 CrossRefPubMed Bacher P, Hohnstein T, Beerbaum E, Rocker M, Blango MG, Kaufmann S, Rohmel J, Eschenhagen P, Grehn C, Seidel K, Rickerts V, Lozza L, Stervbo U, Nienen M, Babel N, Milleck J, Assenmacher M, Cornely OA, Ziegler M, Wisplinghoff H, Heine G, Worm M, Siegmund B, Maul J, Creutz P, Tabeling C, Ruwwe-Glosenkamp C, Sander LE, Knosalla C, Brunke S, Hube B, Kniemeyer O, Brakhage AA, Schwarz C, Scheffold A (2019) Human anti-fungal Th17 immunity and pathology rely on cross-reactivity against Candida albicans. Cell 176(6):1340–1355.e1315. https://​doi.​org/​10.​1016/​j.​cell.​2019.​01.​041 CrossRefPubMed
277.
279.
Zurück zum Zitat Fukawa T, Yan-Jiang BC, Min-Wen JC, Jun-Hao ET, Huang D, Qian CN, Ong P, Li Z, Chen S, Mak SY, Lim WJ, Kanayama HO, Mohan RE, Wang RR, Lai JH, Chua C, Ong HS, Tan KK, Ho YS, Tan IB, Teh BT, Shyh-Chang N (2016) Excessive fatty acid oxidation induces muscle atrophy in cancer cachexia. Nat Med 22(6):666–671. https://doi.org/10.1038/nm.4093 CrossRefPubMed Fukawa T, Yan-Jiang BC, Min-Wen JC, Jun-Hao ET, Huang D, Qian CN, Ong P, Li Z, Chen S, Mak SY, Lim WJ, Kanayama HO, Mohan RE, Wang RR, Lai JH, Chua C, Ong HS, Tan KK, Ho YS, Tan IB, Teh BT, Shyh-Chang N (2016) Excessive fatty acid oxidation induces muscle atrophy in cancer cachexia. Nat Med 22(6):666–671. https://​doi.​org/​10.​1038/​nm.​4093 CrossRefPubMed
281.
Zurück zum Zitat Ikemoto S, Sugimura K, Yoshida N, Wada S, Yamamoto K, Kishimoto T (2000) TNF alpha, IL-1 beta and IL-6 production by peripheral blood monocytes in patients with renal cell carcinoma. Anticancer Res 20(1a):317–321PubMed Ikemoto S, Sugimura K, Yoshida N, Wada S, Yamamoto K, Kishimoto T (2000) TNF alpha, IL-1 beta and IL-6 production by peripheral blood monocytes in patients with renal cell carcinoma. Anticancer Res 20(1a):317–321PubMed
296.
Zurück zum Zitat Akyol M, Demir L, Alacacioglu A, Ellidokuz H, Kucukzeybek Y, Yildiz Y, Gumus Z, Bayoglu V, Yildiz I, Salman T, Varol U, Kucukzeybek B, Demir L, Dirican A, Sutcu R, Tarhan MO (2016) The effects of adjuvant endocrine treatment on serum leptin, serum adiponectin and body composition in patients with breast cancer: the Izmir Oncology Group (IZOG) Study. Chemotherapy 61(2):57–64. https://doi.org/10.1159/000440944 CrossRefPubMed Akyol M, Demir L, Alacacioglu A, Ellidokuz H, Kucukzeybek Y, Yildiz Y, Gumus Z, Bayoglu V, Yildiz I, Salman T, Varol U, Kucukzeybek B, Demir L, Dirican A, Sutcu R, Tarhan MO (2016) The effects of adjuvant endocrine treatment on serum leptin, serum adiponectin and body composition in patients with breast cancer: the Izmir Oncology Group (IZOG) Study. Chemotherapy 61(2):57–64. https://​doi.​org/​10.​1159/​000440944 CrossRefPubMed
297.
Zurück zum Zitat Capozzi LC, McNeely ML, Lau HY, Reimer RA, Giese-Davis J, Fung TS, Culos-Reed SN (2016) Patient-reported outcomes, body composition, and nutrition status in patients with head and neck cancer: results from an exploratory randomized controlled exercise trial. Cancer 122(8):1185–1200. https://doi.org/10.1002/cncr.29863 CrossRefPubMed Capozzi LC, McNeely ML, Lau HY, Reimer RA, Giese-Davis J, Fung TS, Culos-Reed SN (2016) Patient-reported outcomes, body composition, and nutrition status in patients with head and neck cancer: results from an exploratory randomized controlled exercise trial. Cancer 122(8):1185–1200. https://​doi.​org/​10.​1002/​cncr.​29863 CrossRefPubMed
301.
Zurück zum Zitat Grimble RF (1992) Dietary manipulation of the inflammatory response. Proc Nutr Soc 51(2):285–294CrossRefPubMed Grimble RF (1992) Dietary manipulation of the inflammatory response. Proc Nutr Soc 51(2):285–294CrossRefPubMed
302.
Zurück zum Zitat Lefkowith JB, Morrison A, Lee V, Rogers M (1990) Manipulation of the acute inflammatory response by dietary polyunsaturated fatty acid modulation. J Immunol 145(5):1523–1529PubMed Lefkowith JB, Morrison A, Lee V, Rogers M (1990) Manipulation of the acute inflammatory response by dietary polyunsaturated fatty acid modulation. J Immunol 145(5):1523–1529PubMed
303.
Zurück zum Zitat Wan JM, Haw MP, Blackburn GL (1989) Nutrition, immune function, and inflammation: an overview. Proc Nutr Soc 48(3):315–335CrossRefPubMed Wan JM, Haw MP, Blackburn GL (1989) Nutrition, immune function, and inflammation: an overview. Proc Nutr Soc 48(3):315–335CrossRefPubMed
304.
305.
Zurück zum Zitat Grimble RF (1994) Nutritional antioxidants and the modulation of inflammation: theory and practice. New Horiz 2(2):175–185PubMed Grimble RF (1994) Nutritional antioxidants and the modulation of inflammation: theory and practice. New Horiz 2(2):175–185PubMed
307.
Zurück zum Zitat Arends J, Bachmann P, Baracos V, Barthelemy N, Bertz H, Bozzetti F, Fearon K, Hutterer E, Isenring E, Kaasa S, Krznaric Z, Laird B, Larsson M, Laviano A, Muhlebach S, Muscaritoli M, Oldervoll L, Ravasco P, Solheim T, Strasser F, de van der Schueren M, Preiser JC (2017) ESPEN guidelines on nutrition in cancer patients. Clin Nutr 36(1):11–48. https://doi.org/10.1016/j.clnu.2016.07.015 CrossRefPubMed Arends J, Bachmann P, Baracos V, Barthelemy N, Bertz H, Bozzetti F, Fearon K, Hutterer E, Isenring E, Kaasa S, Krznaric Z, Laird B, Larsson M, Laviano A, Muhlebach S, Muscaritoli M, Oldervoll L, Ravasco P, Solheim T, Strasser F, de van der Schueren M, Preiser JC (2017) ESPEN guidelines on nutrition in cancer patients. Clin Nutr 36(1):11–48. https://​doi.​org/​10.​1016/​j.​clnu.​2016.​07.​015 CrossRefPubMed
308.
Zurück zum Zitat Çehrelli R (2018) Molecular nutritional immunology and cancer. J Oncol Sci 4:40–46CrossRef Çehrelli R (2018) Molecular nutritional immunology and cancer. J Oncol Sci 4:40–46CrossRef
309.
Zurück zum Zitat Grimble G (1994) Possible role of short-term parenteral nutrition with fat emulsions for development of haemophagocytosis with multiple organ failure in a patient with traumatic brain injury Roth B, Grande PO, Nillson-Ehle P and Eliasson I. Intensive Care Med 1993; 19: 111-114. Clin Nutr 13 (2):127 Grimble G (1994) Possible role of short-term parenteral nutrition with fat emulsions for development of haemophagocytosis with multiple organ failure in a patient with traumatic brain injury Roth B, Grande PO, Nillson-Ehle P and Eliasson I. Intensive Care Med 1993; 19: 111-114. Clin Nutr 13 (2):127
310.
Zurück zum Zitat Grimble G (1994) Can daily dietary arginine supplement affect the function and subpopulation of lymphocytes in patients with advanced gastric cancer? Wu C-W, Chi C-W, Chiu C-C, Liu W-Y, P’eng F-K and Wang S-R. Digestion 1993; 54: 118-124. Clin Nutr 13 (2):127–128 Grimble G (1994) Can daily dietary arginine supplement affect the function and subpopulation of lymphocytes in patients with advanced gastric cancer? Wu C-W, Chi C-W, Chiu C-C, Liu W-Y, P’eng F-K and Wang S-R. Digestion 1993; 54: 118-124. Clin Nutr 13 (2):127–128
320.
328.
Zurück zum Zitat Ramos-Lopez O, Milagro FI, Allayee H, Chmurzynska A, Choi MS, Curi R, De Caterina R, Ferguson LR, Goni L, Kang JX, Kohlmeier M, Marti A, Moreno LA, Perusse L, Prasad C, Qi L, Reifen R, Riezu-Boj JI, San-Cristobal R, Santos JL, Martinez JA (2017) Guide for current nutrigenetic, nutrigenomic, and nutriepigenetic approaches for precision nutrition involving the prevention and management of chronic diseases associated with obesity. J Nutrigenet Nutrigenomics 10(1–2):43–62. https://doi.org/10.1159/000477729 CrossRefPubMed Ramos-Lopez O, Milagro FI, Allayee H, Chmurzynska A, Choi MS, Curi R, De Caterina R, Ferguson LR, Goni L, Kang JX, Kohlmeier M, Marti A, Moreno LA, Perusse L, Prasad C, Qi L, Reifen R, Riezu-Boj JI, San-Cristobal R, Santos JL, Martinez JA (2017) Guide for current nutrigenetic, nutrigenomic, and nutriepigenetic approaches for precision nutrition involving the prevention and management of chronic diseases associated with obesity. J Nutrigenet Nutrigenomics 10(1–2):43–62. https://​doi.​org/​10.​1159/​000477729 CrossRefPubMed
330.
Zurück zum Zitat Minihane AM, Khan S, Leigh-Firbank EC, Talmud P, Wright JW, Murphy MC, Griffin BA, Williams CM (2000) ApoE polymorphism and fish oil supplementation in subjects with an atherogenic lipoprotein phenotype. Arterioscler Thromb Vasc Biol 20(8):1990–1997CrossRefPubMed Minihane AM, Khan S, Leigh-Firbank EC, Talmud P, Wright JW, Murphy MC, Griffin BA, Williams CM (2000) ApoE polymorphism and fish oil supplementation in subjects with an atherogenic lipoprotein phenotype. Arterioscler Thromb Vasc Biol 20(8):1990–1997CrossRefPubMed
331.
Zurück zum Zitat Grimble RF, Howell WM, O’Reilly G, Turner SJ, Markovic O, Hirrell S, East JM, Calder PC (2002) The ability of fish oil to suppress tumor necrosis factor alpha production by peripheral blood mononuclear cells in healthy men is associated with polymorphisms in genes that influence tumor necrosis factor alpha production. Am J Clin Nutr 76(2):454–459. https://doi.org/10.1093/ajcn/76.2.454 CrossRefPubMed Grimble RF, Howell WM, O’Reilly G, Turner SJ, Markovic O, Hirrell S, East JM, Calder PC (2002) The ability of fish oil to suppress tumor necrosis factor alpha production by peripheral blood mononuclear cells in healthy men is associated with polymorphisms in genes that influence tumor necrosis factor alpha production. Am J Clin Nutr 76(2):454–459. https://​doi.​org/​10.​1093/​ajcn/​76.​2.​454 CrossRefPubMed
332.
Zurück zum Zitat Paoloni-Giacobino A, Grimble R, Pichard C (2003) Genomic interactions with disease and nutrition. Clin Nutr 22(6):507–514CrossRefPubMed Paoloni-Giacobino A, Grimble R, Pichard C (2003) Genomic interactions with disease and nutrition. Clin Nutr 22(6):507–514CrossRefPubMed
333.
335.
Zurück zum Zitat Wang Y, Zheng J, Gao Z, Han X, Qiu F (2018) Investigation on nutritional risk assessment and nutritional support status of surgical patients with colorectal cancer. J buon 23(1):62–67PubMed Wang Y, Zheng J, Gao Z, Han X, Qiu F (2018) Investigation on nutritional risk assessment and nutritional support status of surgical patients with colorectal cancer. J buon 23(1):62–67PubMed
337.
Zurück zum Zitat Guertin MH, Robitaille K, Pelletier JF, Duchesne T, Julien P, Savard J, Bairati I, Fradet V (2018) Effects of concentrated long-chain omega-3 polyunsaturated fatty acid supplementation before radical prostatectomy on prostate cancer proliferation, inflammation, and quality of life: study protocol for a phase IIb, randomized, double-blind, placebo-controlled trial. BMC Cancer 18(1):64. https://doi.org/10.1186/s12885-017-3979-9 CrossRefPubMedPubMedCentral Guertin MH, Robitaille K, Pelletier JF, Duchesne T, Julien P, Savard J, Bairati I, Fradet V (2018) Effects of concentrated long-chain omega-3 polyunsaturated fatty acid supplementation before radical prostatectomy on prostate cancer proliferation, inflammation, and quality of life: study protocol for a phase IIb, randomized, double-blind, placebo-controlled trial. BMC Cancer 18(1):64. https://​doi.​org/​10.​1186/​s12885-017-3979-9 CrossRefPubMedPubMedCentral
340.
Zurück zum Zitat Vodnala SK, Eil R, Kishton RJ, Sukumar M, Yamamoto TN, Ha NH, Lee PH, Shin M, Patel SJ, Yu Z, Palmer DC, Kruhlak MJ, Liu X, Locasale JW, Huang J, Roychoudhuri R, Finkel T, Klebanoff CA, Restifo NP (2019) T cell stemness and dysfunction in tumors are triggered by a common mechanism. Science 363(6434). https://doi.org/10.1126/science.aau0135 Vodnala SK, Eil R, Kishton RJ, Sukumar M, Yamamoto TN, Ha NH, Lee PH, Shin M, Patel SJ, Yu Z, Palmer DC, Kruhlak MJ, Liu X, Locasale JW, Huang J, Roychoudhuri R, Finkel T, Klebanoff CA, Restifo NP (2019) T cell stemness and dysfunction in tumors are triggered by a common mechanism. Science 363(6434). https://​doi.​org/​10.​1126/​science.​aau0135
341.
Zurück zum Zitat Eil R, Vodnala SK, Clever D, Klebanoff CA, Sukumar M, Pan JH, Palmer DC, Gros A, Yamamoto TN, Patel SJ, Guittard GC, Yu Z, Carbonaro V, Okkenhaug K, Schrump DS, Linehan WM, Roychoudhuri R, Restifo NP (2016) Ionic immune suppression within the tumour microenvironment limits T cell effector function. Nature 537(7621):539–543. https://doi.org/10.1038/nature19364 CrossRefPubMedPubMedCentral Eil R, Vodnala SK, Clever D, Klebanoff CA, Sukumar M, Pan JH, Palmer DC, Gros A, Yamamoto TN, Patel SJ, Guittard GC, Yu Z, Carbonaro V, Okkenhaug K, Schrump DS, Linehan WM, Roychoudhuri R, Restifo NP (2016) Ionic immune suppression within the tumour microenvironment limits T cell effector function. Nature 537(7621):539–543. https://​doi.​org/​10.​1038/​nature19364 CrossRefPubMedPubMedCentral
346.
Zurück zum Zitat Grzybowski S, Dorken E (1983) Tuberculosis in Inuit. Ecol Dis 2(2):145–148PubMed Grzybowski S, Dorken E (1983) Tuberculosis in Inuit. Ecol Dis 2(2):145–148PubMed
350.
351.
354.
358.
Zurück zum Zitat Balmer ML, Ma EH, Bantug GR, Grahlert J, Pfister S, Glatter T, Jauch A, Dimeloe S, Slack E, Dehio P, Krzyzaniak MA, King CG, Burgener AV, Fischer M, Develioglu L, Belle R, Recher M, Bonilla WV, Macpherson AJ, Hapfelmeier S, Jones RG, Hess C (2016) Memory CD8(+) T cells require increased concentrations of acetate induced by stress for optimal function. Immunity 44(6):1312–1324. https://doi.org/10.1016/j.immuni.2016.03.016 CrossRefPubMed Balmer ML, Ma EH, Bantug GR, Grahlert J, Pfister S, Glatter T, Jauch A, Dimeloe S, Slack E, Dehio P, Krzyzaniak MA, King CG, Burgener AV, Fischer M, Develioglu L, Belle R, Recher M, Bonilla WV, Macpherson AJ, Hapfelmeier S, Jones RG, Hess C (2016) Memory CD8(+) T cells require increased concentrations of acetate induced by stress for optimal function. Immunity 44(6):1312–1324. https://​doi.​org/​10.​1016/​j.​immuni.​2016.​03.​016 CrossRefPubMed
364.
Zurück zum Zitat Berry MP, Graham CM, McNab FW, Xu Z, Bloch SA, Oni T, Wilkinson KA, Banchereau R, Skinner J, Wilkinson RJ, Quinn C, Blankenship D, Dhawan R, Cush JJ, Mejias A, Ramilo O, Kon OM, Pascual V, Banchereau J, Chaussabel D, O’Garra A (2010) An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis. Nature 466(7309):973–977. https://doi.org/10.1038/nature09247 CrossRefPubMedPubMedCentral Berry MP, Graham CM, McNab FW, Xu Z, Bloch SA, Oni T, Wilkinson KA, Banchereau R, Skinner J, Wilkinson RJ, Quinn C, Blankenship D, Dhawan R, Cush JJ, Mejias A, Ramilo O, Kon OM, Pascual V, Banchereau J, Chaussabel D, O’Garra A (2010) An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis. Nature 466(7309):973–977. https://​doi.​org/​10.​1038/​nature09247 CrossRefPubMedPubMedCentral
365.
Zurück zum Zitat Teles RM, Graeber TG, Krutzik SR, Montoya D, Schenk M, Lee DJ, Komisopoulou E, Kelly-Scumpia K, Chun R, Iyer SS, Sarno EN, Rea TH, Hewison M, Adams JS, Popper SJ, Relman DA, Stenger S, Bloom BR, Cheng G, Modlin RL (2013) Type I interferon suppresses type II interferon-triggered human anti-mycobacterial responses. Science 339(6126):1448–1453. https://doi.org/10.1126/science.1233665 CrossRefPubMedPubMedCentral Teles RM, Graeber TG, Krutzik SR, Montoya D, Schenk M, Lee DJ, Komisopoulou E, Kelly-Scumpia K, Chun R, Iyer SS, Sarno EN, Rea TH, Hewison M, Adams JS, Popper SJ, Relman DA, Stenger S, Bloom BR, Cheng G, Modlin RL (2013) Type I interferon suppresses type II interferon-triggered human anti-mycobacterial responses. Science 339(6126):1448–1453. https://​doi.​org/​10.​1126/​science.​1233665 CrossRefPubMedPubMedCentral
366.
Zurück zum Zitat Mayer-Barber KD, Andrade BB, Oland SD, Amaral EP, Barber DL, Gonzales J, Derrick SC, Shi R, Kumar NP, Wei W, Yuan X, Zhang G, Cai Y, Babu S, Catalfamo M, Salazar AM, Via LE, Barry CE 3rd, Sher A (2014) Host-directed therapy of tuberculosis based on interleukin-1 and type I interferon crosstalk. Nature 511(7507):99–103. https://doi.org/10.1038/nature13489 CrossRefPubMedPubMedCentral Mayer-Barber KD, Andrade BB, Oland SD, Amaral EP, Barber DL, Gonzales J, Derrick SC, Shi R, Kumar NP, Wei W, Yuan X, Zhang G, Cai Y, Babu S, Catalfamo M, Salazar AM, Via LE, Barry CE 3rd, Sher A (2014) Host-directed therapy of tuberculosis based on interleukin-1 and type I interferon crosstalk. Nature 511(7507):99–103. https://​doi.​org/​10.​1038/​nature13489 CrossRefPubMedPubMedCentral
386.
Zurück zum Zitat Wang Z, Yip LY, Lee JHJ, Wu Z, Chew HY, Chong PKW, Teo CC, Ang HY, Peh KLE, Yuan J, Ma S, Choo LSK, Basri N, Jiang X, Yu Q, Hillmer AM, Lim WT, Lim TKH, Takano A, Tan EH, Tan DSW, Ho YS, Lim B, Tam WL (2019) Methionine is a metabolic dependency of tumor-initiating cells. Nat Med 25(5):825–837. https://doi.org/10.1038/s41591-019-0423-5 CrossRefPubMed Wang Z, Yip LY, Lee JHJ, Wu Z, Chew HY, Chong PKW, Teo CC, Ang HY, Peh KLE, Yuan J, Ma S, Choo LSK, Basri N, Jiang X, Yu Q, Hillmer AM, Lim WT, Lim TKH, Takano A, Tan EH, Tan DSW, Ho YS, Lim B, Tam WL (2019) Methionine is a metabolic dependency of tumor-initiating cells. Nat Med 25(5):825–837. https://​doi.​org/​10.​1038/​s41591-019-0423-5 CrossRefPubMed
393.
Zurück zum Zitat Fallarino F, Grohmann U, You S, McGrath BC, Cavener DR, Vacca C, Orabona C, Bianchi R, Belladonna ML, Volpi C, Santamaria P, Fioretti MC, Puccetti P (2006) The combined effects of tryptophan starvation and tryptophan catabolites down-regulate T cell receptor zeta-chain and induce a regulatory phenotype in naive T cells. J Immunol 176(11):6752–6761. https://doi.org/10.4049/jimmunol.176.11.6752 CrossRefPubMed Fallarino F, Grohmann U, You S, McGrath BC, Cavener DR, Vacca C, Orabona C, Bianchi R, Belladonna ML, Volpi C, Santamaria P, Fioretti MC, Puccetti P (2006) The combined effects of tryptophan starvation and tryptophan catabolites down-regulate T cell receptor zeta-chain and induce a regulatory phenotype in naive T cells. J Immunol 176(11):6752–6761. https://​doi.​org/​10.​4049/​jimmunol.​176.​11.​6752 CrossRefPubMed
400.
Zurück zum Zitat Ida S, Hiki N, Cho H, Sakamaki K, Ito S, Fujitani K, Takiguchi N, Kawashima Y, Nishikawa K, Sasako M, Aoyama T, Honda M, Sato T, Nunobe S, Yoshikawa T (2017) Randomized clinical trial comparing standard diet with perioperative oral immunonutrition in total gastrectomy for gastric cancer. Br J Surg 104(4):377–383. https://doi.org/10.1002/bjs.10417 CrossRefPubMed Ida S, Hiki N, Cho H, Sakamaki K, Ito S, Fujitani K, Takiguchi N, Kawashima Y, Nishikawa K, Sasako M, Aoyama T, Honda M, Sato T, Nunobe S, Yoshikawa T (2017) Randomized clinical trial comparing standard diet with perioperative oral immunonutrition in total gastrectomy for gastric cancer. Br J Surg 104(4):377–383. https://​doi.​org/​10.​1002/​bjs.​10417 CrossRefPubMed
401.
Zurück zum Zitat Miyata H, Yano M, Yasuda T, Yamasaki M, Murakami K, Makino T, Nishiki K, Sugimura K, Motoori M, Shiraishi O, Mori M, Doki Y (2017) Randomized study of the clinical effects of omega-3 fatty acid-containing enteral nutrition support during neoadjuvant chemotherapy on chemotherapy-related toxicity in patients with esophageal cancer. Nutrition 33:204–210. https://doi.org/10.1016/j.nut.2016.07.004 CrossRefPubMed Miyata H, Yano M, Yasuda T, Yamasaki M, Murakami K, Makino T, Nishiki K, Sugimura K, Motoori M, Shiraishi O, Mori M, Doki Y (2017) Randomized study of the clinical effects of omega-3 fatty acid-containing enteral nutrition support during neoadjuvant chemotherapy on chemotherapy-related toxicity in patients with esophageal cancer. Nutrition 33:204–210. https://​doi.​org/​10.​1016/​j.​nut.​2016.​07.​004 CrossRefPubMed
402.
Zurück zum Zitat Sorensen LS, Thorlacius-Ussing O, Rasmussen HH, Lundbye-Christensen S, Calder PC, Lindorff-Larsen K, Schmidt EB (2014) Effects of perioperative supplementation with omega-3 fatty acids on leukotriene B(4) and leukotriene B(5) production by stimulated neutrophils in patients with colorectal cancer: a randomized, placebo-controlled intervention trial. Nutrients 6(10):4043–4057. https://doi.org/10.3390/nu6104043 CrossRefPubMedPubMedCentral Sorensen LS, Thorlacius-Ussing O, Rasmussen HH, Lundbye-Christensen S, Calder PC, Lindorff-Larsen K, Schmidt EB (2014) Effects of perioperative supplementation with omega-3 fatty acids on leukotriene B(4) and leukotriene B(5) production by stimulated neutrophils in patients with colorectal cancer: a randomized, placebo-controlled intervention trial. Nutrients 6(10):4043–4057. https://​doi.​org/​10.​3390/​nu6104043 CrossRefPubMedPubMedCentral
403.
Zurück zum Zitat Mocellin MC, Pastore e Silva Jde A, Camargo Cde Q, Fabre ME, Gevaerd S, Naliwaiko K, Moreno YM, Nunes EA, Trindade EB (2013) Fish oil decreases C-reactive protein/albumin ratio improving nutritional prognosis and plasma fatty acid profile in colorectal cancer patients. Lipids 48(9):879–888. https://doi.org/10.1007/s11745-013-3816-0 CrossRefPubMed Mocellin MC, Pastore e Silva Jde A, Camargo Cde Q, Fabre ME, Gevaerd S, Naliwaiko K, Moreno YM, Nunes EA, Trindade EB (2013) Fish oil decreases C-reactive protein/albumin ratio improving nutritional prognosis and plasma fatty acid profile in colorectal cancer patients. Lipids 48(9):879–888. https://​doi.​org/​10.​1007/​s11745-013-3816-0 CrossRefPubMed
406.
Zurück zum Zitat Trabal J, Leyes P, Forga M, Maurel J (2010) Potential usefulness of an EPA-enriched nutritional supplement on chemotherapy tolerability in cancer patients without overt malnutrition. Nutr Hosp 25(5):736–740PubMed Trabal J, Leyes P, Forga M, Maurel J (2010) Potential usefulness of an EPA-enriched nutritional supplement on chemotherapy tolerability in cancer patients without overt malnutrition. Nutr Hosp 25(5):736–740PubMed
407.
408.
409.
Zurück zum Zitat Marano L, Porfidia R, Pezzella M, Grassia M, Petrillo M, Esposito G, Braccio B, Gallo P, Boccardi V, Cosenza A, Izzo G, Di Martino N (2013) Clinical and immunological impact of early postoperative enteral immunonutrition after total gastrectomy in gastric cancer patients: a prospective randomized study. Ann Surg Oncol 20(12):3912–3918. https://doi.org/10.1245/s10434-013-3088-1 CrossRefPubMed Marano L, Porfidia R, Pezzella M, Grassia M, Petrillo M, Esposito G, Braccio B, Gallo P, Boccardi V, Cosenza A, Izzo G, Di Martino N (2013) Clinical and immunological impact of early postoperative enteral immunonutrition after total gastrectomy in gastric cancer patients: a prospective randomized study. Ann Surg Oncol 20(12):3912–3918. https://​doi.​org/​10.​1245/​s10434-013-3088-1 CrossRefPubMed
410.
Zurück zum Zitat Okamoto Y, Okano K, Izuishi K, Usuki H, Wakabayashi H, Suzuki Y (2009) Attenuation of the systemic inflammatory response and infectious complications after gastrectomy with preoperative oral arginine and omega-3 fatty acids supplemented immunonutrition. World J Surg 33(9):1815–1821. https://doi.org/10.1007/s00268-009-0140-1 CrossRefPubMed Okamoto Y, Okano K, Izuishi K, Usuki H, Wakabayashi H, Suzuki Y (2009) Attenuation of the systemic inflammatory response and infectious complications after gastrectomy with preoperative oral arginine and omega-3 fatty acids supplemented immunonutrition. World J Surg 33(9):1815–1821. https://​doi.​org/​10.​1007/​s00268-009-0140-1 CrossRefPubMed
Metadaten
Titel
Immunometabolism: new insights and lessons from antigen-directed cellular immune responses
verfasst von
Renata Ramalho
Martin Rao
Chao Zhang
Chiara Agrati
Giuseppe Ippolito
Fu-Sheng Wang
Alimuddin Zumla
Markus Maeurer
Publikationsdatum
09.06.2020
Verlag
Springer Berlin Heidelberg
Erschienen in
Seminars in Immunopathology / Ausgabe 3/2020
Print ISSN: 1863-2297
Elektronische ISSN: 1863-2300
DOI
https://doi.org/10.1007/s00281-020-00798-w

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