Erschienen in:
01.07.2009 | Oncology
Treatment response classification of liver metastatic disease evaluated on imaging. Are RECIST unidimensional measurements accurate?
verfasst von:
Michael Mantatzis, Stylianos Kakolyris, Kyriakos Amarantidis, Anastasios Karayiannakis, Panos Prassopoulos
Erschienen in:
European Radiology
|
Ausgabe 7/2009
Einloggen, um Zugang zu erhalten
Abstract
The purpose of this study was to evaluate the accuracy of unidimensional measurements (response evaluation criteria in solid tumors, RECIST) compared with volumetric measurements in patients with liver metastases undergoing chemotherapy. Forty-four patients with newly diagnosed liver lesions underwent three MRI examinations at treatment initiation, during chemotherapy, and immediately post-treatment. Measurements based on RECIST guidelines and volume calculations were performed on the “target” lesions (TLs). The two methods were in agreement in 64/77 of patients and 253/301 of individual lesions classification in response categories (“good” agreement, Cohen kappa = 0.735 and 0.741, respectively). In 16.88% of the comparisons the two methods stratified patients to a different response category; 27.6% of TLs did not follow the response category of the patient in whom lesions were located. The actual volume of TLs differs from the calculated volume of a sphere with the same diameter. Our study supports the use of volumetric techniques that may overcome certain disadvantages of unidimensional measurements.