Introduction
Materials and methods
Search strategy
Study selection
Data extraction
Quality assessment
Statistical analysis and data synthesis
Results
Author | Journal | Year | Technique | Country | Type | Patients (n) | Mean age | Age SD | % male | Patientsa
| Brand | Tesla | Perfusion tests | Assessment | Stressor | CAD definition |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Arnold et al. [21] | JACC Cardiovasc Imaging | 2010 | MRI | UK | N | 65 | 64 | 9 | 65 | S&K | Siemens | 3 | Rest, stress, DE | Qualitative | Adenosine | ≥50 % |
Bernhardt et al. [22] | JACC Cardiovasc Imaging | 2009 | MRI | Germany and Canada | A | 823 | 64 | 12 | 76 | S&K | Philips | 1.5 | Stress, DEb
| Qualitative | Adenosine | ≥70 % |
Cheng et al. [23] | J Am Coll Cardiol | 2007 | MRI | UK | A | 61 | 64 | 8 | 75 | S&K | Siemens | 3 | Rest, stress | Qualitative | Adenosine | ≥50 % |
Cury et al. [24] | Radiology | 2006 | MRI | Brasil | N | 46 | 63 | 5 | 81 | S&K | GE | 1.5 | Stress, DE | Qualitative | Dipyridamole | ≥70 % |
Donati et al. [25] | Am J Roentgenol | 2010 | MRI | Switzerland | A | 65 | 64 | 9 | 81 | S&K | Philips | 1.5 | Rest, stress, DE | Qualitative | Adenosine | >50 % |
Doyle et al. [26] | J Cardiovasc Magn Reson | 2003 | MRI | USA | A | 184 | 59 | 11 | 0 | NS | Philips | 1.5 | Rest, stress | Semi-quantitative | Dipyridamole | ≥70 % |
Gebker et al. [27] | Radiology | 2007 | MRI | Germany | N | 40 | 61 | 8 | 70 | S&K | Philips | 1.5 | Rest, stress, DE | Qualitative | Adenosine | ≥50 % |
Gebker et al. [28] | Radiology | 2008 | MRI | Germany | N | 101 | 62 | 8 | 70 | S&K | Philips | 3 | Rest, stress, DE | Qualitative | Adenosine | ≥50 % |
Gebker et al. [29] | Int J Cardiol | 2011 | MRI | Germany | N | 78 | 65 | 10 | 76 | S&K | Philips | 1.5 | Rest, stress, DE | Qualitative | Dobutamine/atropine | ≥70 % |
Giang et al. [30] | Eur Heart J | 2004 | MRI | Switzerland | A | 44 | 58 | NA | 78 | S&K | GE | 1.5 | Stress | Semi-quantitative | Adenosine | ≥50 % |
Kawase et al. [31] | Osaka City Med J | 2004 | MRI | Japan | N | 50 | 67 | 12 | 58 | NS | Philips | 1.5 | Rest, stress | Qualitative | Nicorandil | ≥70 % |
Kitagawa, et al. [32] | Eur Radiol | 2008 | MRI | Japan | A | 50 | 65 | 9 | 72 | S&K | GE | 1.5 | Rest, stress, DE | Qualitative | ATP | ≥50 % |
Klein et al. [33] | J Cardiovasc Magn Reson | 2008 | MRI | Germany | N | 51 | 60 | 10 | 65 | NS | Philips | 1.5 | Rest, stress, DE | Qualitative | Adenosine | >50 % |
Klein et al. [34] | JACC Cardiovasc Imaging | 2009 | MRI | UK and Germany | A | 78 | 66 | 8 | 90 | K | Philips | 1.5 | Stress, DE | Qualitative | Adenosine | >50 % |
Klem et al. [35] | J Am Coll Cardiol | 2006 | MRI | USA | A | 92 | 58 | 12 | 49 | S | Siemens | 1.5 | Rest, stress, DEb
| Qualitative | Adenosine | ≥50 % and ≥70 % (≥50 LM) |
Klumpp et al. [36] | Eur Radiol | 2010 | MRI | Germany | A | 57 | 62 | 11 | 82 | S&K | Siemens | 3 | Rest, stress, DE | Qualitative | Adenosine | >70 % |
Krittayaphong et al. [37] | Int J Cardiovasc Imaging | 2009 | MRI | Thailand | A | 66 | 61 | 12 | 58 | S | Philips | 1.5 | Rest, stress | Semi-quantitative | Adenosine | ≥50 % |
Merkle et al. [38] | Heart | 2007 | MRI | Germany | A | 228 | 61 | 11 | 79 | S&K | Philips | 1.5 | Rest, stress, DE | Qualitative | Adenosine | >50 % and >70 % |
Meyer et al. [39] | Eur Radiol | 2008 | MRI | Germany | A | 60 | 59 | 10 | 63 | S&K | Philips | 3 | Rest, stress, DE | Qualitative | Adenosine | ≥70 % |
Nagel et al. [40] | Circulation | 2003 | MRI | Germany | A | 84 | 63 | 8 | 81 | S | Philips | 1.5 | Rest, stress | Semi-quantitative | Adenosine | ≥75 %‡
|
Paetsch et al. [41] | Circulation | 2004 | MRI | Germany | N | 79 | 61 | 9 | 66 | S&K | Philips | 1.5 | Rest, stress | Qualitative | Adenosine | >50 % |
Pilz et al. [42] | Clin Res Cardiol | 2006 | MRI | Germany | A | 171 | 62 | 12 | 63 | S&K | GE | 1.5 | Rest, stress, DE | Qualitative | Adenosine | >70 % |
Pingitore et al. [43] | Am J Cardiol | 2008 | MRI | Italy | A | 93 | 61 | NA | 70 | S&K | GE | 1.5 | Rest, stress | Quantitative | Dipyridamole | >50 % |
Plein et al. [44] | Radiology | 2005 | MRI | UK | N | 82 | 58 | NA | 74 | S&K | Philips | 1.5 | Rest, stress | Semi-quantitative | Adenosine | >70 % |
Plein et al. [45] | Eur Heart J | 2008 | MRI | Switzerland | A | 51 | 59 | 10 | 76 | S&K | Philips | 1.5 | Stress, DE | Qualitative | Adenosine | >50 % |
Plein et al. [46] | Radiology | 2008 | MRI | Switzerland and UK | A | 33 | 58 | 11 | 73 | S&K | Philips | 3 | Stress, DE | Qualitative | Adenosine | >50 % |
Stolzmann et al. [47] | Int J Cardiovasc Imaging | 2010 | MRI | Switzerland | A | 65 | 64 | 10 | 87 | NS | Philips | 1.5 | Rest, stress, DE | Semi-quantitative | Adenosine | >50 % |
Takase et al. [48] | Jpn Heart J | 2004 | MRI | Japan | N | 102 | 66 | 9 | 83 | S&K | GE | 1.5 | Rest, stress, DE | Qualitative | Dipyridamole | >50 % |
Author | Journal | Year | Technique | Country | Type | Patients (n) | Mean age | Age SD | % male | Patients | Brand | Contrast agent | Perfusion tests | Assessment | Stressor | CAD definition |
Aggeli et al. [49] | Am J Hypertens | 2007 | ECHO | Greece | A | 50 | 67 | 5 | 68 | S | Philips | SonoVue | Rest, stress | Qualitative | Adenosine | ≥50 % |
Arnold et al. [21] | JACC Cardiovasc Imaging | 2010 | ECHO | UK | N | 65 | 64 | 9 | 65 | S&K | Philips | Optison | Rest, stress | Qualitative | Adenosine | ≥50 % |
Chiou et al. [50] | Can J Cardiol | 2004 | ECHO | Taiwan | N | 132 | 67 | 11 | 75 | S&K | Philips | PESDA | Rest, stress | Qualitative | Dobutamine | ≥50 % (≥40 % LM) |
Jeetley et al. [51] | J Am Coll Cardiol | 2006 | ECHO | UK | A/N | 123 | 62 | 12 | 71 | S&K | Philips | Sonazoid | Rest, stress | Semi-quantitative | Dipyridamole | ≥70 % |
Kowatsch et al. [52] | J Am Soc Echocardiogr | 2007 | ECHO | Brasil | A | 54 | 60 | 9 | 61 | S&K | Philips | PESDA | Rest, stress | Quantitative | Adenosine | >50 % |
Lipiec et al. [53] | J Am Soc Echocardiogr | 2008 | ECHO | Poland | A | 103 | 58 | 9 | 63 | S&K | Siemens | Optison | Rest, stress | Qualitative | Dipyridamole or atropine | ≥70 % |
Miszalski-Jamka et al. [54] | Int J Cardiol | 2009 | ECHO | Poland | A | 103 | 58 | NA | 80 | S&K | Philips | Sonovue | Rest, stress | Qualitative | Exercise | ≥50 % |
Moir et al. [55] | J Am Soc Echocardiogr | 2005 | ECHO | Australia | A | 79 | 56 | NA | 80 | S&K | Philips | Definity | Rest, stress | Quantitative | Dipyridamole, exercise | ≥50 % |
Peltier et al. [56] | J Am Coll Cardiol | 2004 | ECHO | Belgium | A | 35 | 62 | 10 | 71 | S&K | Agilent Technologies | PESDA | Rest, stress | Quantitative | Dipyridamole | >70 % |
Senior et al. [57] | Am Heart J | 2004 | ECHO | UK, Germany, Belgium | N | 54 | 61†
| NA | 82 | NS | Philips | Sonazoid | Rest, stress | Qualitative | Dipyridamole | >50 % |
Author | Journal | Year | Technique | Country | Type | Patients (n) | Mean age | Age SD | % male | Patients | Brand | Radiotracer | Perfusion tests | Assessment | Stressor | CAD definition |
Aggeli et al. [49] | Am J Hypertens | 2007 | SPECT | Greece | A | 48 | 67 | 5 | 68 | S | GE |
201Tl | Rest, stress | Qualitative and qualitative | Adenosine | ≥50 % |
Astarita et al. [58] | J Hypertens | 2001 | SPECT | Italy | N | 53 | 58 | 10 | 55 | S | Picker |
201Tl | Rest, stress | Qualitative | Exercise | ≥50 % |
Budoff et al. [59] | Acad Radiol | 2007 | SPECT | USA | A | 30 | 54 | 9 | 70 | NS | NS |
99mTc-MIBI | Rest, stress | Qualitative | Exercise | >70 % (>50 % LM) |
Doyle et al. [26] | J Cardiovasc Magn Reson | 2003 | SPECT | USA | A | 184 | 59 | 11 | 0 | NS | ADAC |
99mTc-MIBI/201Tl | Rest, stress (gated) | Qualitative | Dipyridamole | ≥70 % |
Gonzalez et al. [60] | Rev Esp Med Nucl | 2005 | SPECT | Chile | A | 145 | 60 | 12 | 68 | S&K | GE |
201Tl | Rest, stress | Qualitative | Exercise (n = 63), dipyridamole (n = 82) | ≥50 % and ≥75 % |
Jeetley et al. [51] | J Am Coll Cardiol | 2006 | SPECT | UK | A/N | 123 | 62 | 12 | 71 | S&K | NS |
99mTc-MIBI | Rest, stress | Semi-quantitative | Dipyridamole | ≥70 % |
Johansen et al. [61] | J Nucl Cardiol | 2005 | SPECT | Denmark | A | 357 | 57 | 9 | 54 | S | Picker |
201Tl(rest) and 99mTc-MIBI (stress) | Rest, stress (gated) | Semi-quantitative | Adenosine or dobutamine (n = 180), exercise stress test (n = 177) | ≥50 % |
Lipiec et al. [53] | J Am Soc Echocardiogr | 2008 | SPECT | Poland | A | 103 | 58 | 9 | 63 | S&K | GE |
99mTc-MIBI | Rest, stress | Semi-quantitative | Dipyridamole | ≥70 % |
Peltier et al. [56] | J Am Coll Cardiol | 2004 | SPECT | Belgium | A | 35 | 62 | 10 | 71 | S&K | GE |
99mTc-MIBI | Rest, stress | Qualitative | Dipyridamole | >70 % |
Schepis et al. [62] | J Nucl Med | 2007 | SPECT | Switzerland | A | 77 | 66 | 9 | 62 | S | GE |
99mTc-tetrofosmin | Rest, stress (gated) | Semi-quantitative | Adenosine | ≥50 % |
Senior et al. [57] | Am Heart J | 2004 | SPECT | UK, Germany, Belgium | N | 53 | 61†
| NA | 82 | NS | Amersham Health |
99mTc-tetrofosmin | Rest, stress | Qualitative | Dipyridamole | >50 % |
Yao et al. [63] | Nucl Med Commun | 2000 | SPECT | China | N | 64 | 51 | NA | 95 | S&K | Siemens |
99mTc-MIBI | Rest, stress | Qualitative | Exercise | ≥50 % |
Yeih et al. [64] | J Formos Med Assoc | 2007 | SPECT | Taiwan | A | 51 | 63 | 9 | 0 | S&K | GE |
201Tl | Rest, stress | Qualitative | Dobutamine | ≥50 % |
Author | Year | Technique | TP | FN | TN | FP | Sensitivity (%) | Specificity (%) | CAD definition |
---|---|---|---|---|---|---|---|---|---|
Arnold et al. [21] | 2010 | MRI | 37 | 4 | 17 | 4 | 90.2 | 81.0 | ≥50 % |
Bernhardt et al. [22] | 2009 | MRI | 274 | 39 | 421 | 89 | 87.5 | 82.5 | ≥70 % |
Cheng et al. [23] | 2007 | MRI | 39 | 1 | 16 | 5 | 97.5 | 76.2 | ≥50 % |
Cury et al. [24] | 2006 | MRI | 29 | 1 | 12 | 4 | 96.7 | 75.0 | ≥70 % |
Donati et al. [25] | 2010 | MRI | 30 | 3 | 14 | 0 | 90.9 | 100 | >50 % |
Doyle et al. [26] | 2003 | MRI | 15 | 11 | 123 | 35 | 57.7 | 77.8 | ≥70 % |
Gebker et al. [27] | 2007 | MRI | 19 | 3 | 14 | 4 | 86.4 | 77.8 | ≥50 % |
Gebker et al. [28] | 2008 | MRI | 63 | 7 | 22 | 9 | 90.0 | 71.0 | ≥50 % |
Gebker et al. [29] | 2011 | MRI | 48 | 4 | 19 | 4 | 92.3 | 82.6 | ≥70 % |
Giang et al. [30] | 2004 | MRI | 26 | 2 | 12 | 4 | 92.9 | 75.0 | ≥50 % |
Kawase et al. [31] | 2004 | MRI | 31 | 2 | 16 | 1 | 93.9 | 94.1 | ≥70 % |
Kitagawa et al. [32] | 2008 | MRI | 33 | 3 | 8 | 6 | 91.7 | 57.1 | ≥50 % |
Klein et al. [33] | 2008 | MRI | 22 | 3 | 23 | 3 | 88.0 | 88.5 | >50 % |
Klein et al. [34] | 2009 | MRI | 36 | 18 | 21 | 3 | 66.7 | 87.5 | >50 % |
Klem et al. [35] | 2006 | MRI | 34 | 10 | 42 | 6 | 77.3 | 87.5 | ≥50 % |
33 | 4 | 48 | 7 | 89.2 | 87.3 | ≥70 % (≥50 LM) | |||
Klumpp et al. [36] | 2010 | MRI | 40 | 1 | 14 | 2 | 97.6 | 87.5 | >70 % |
Krittayaphong et al. [37] | 2009 | MRI | 34 | 4 | 22 | 6 | 89.5 | 78.6 | ≥50 % |
Merkle et al. [38] | 2007 | MRI | 160 | 12 | 48 | 8 | 93.0 | 85.7 | >50 % |
147 | 6 | 54 | 21 | 96.1 | 72.0 | >70 % | |||
Meyer et al. [39] | 2008 | MRI | 32 | 4 | 19 | 5 | 88.9 | 79.2 | ≥70 % |
Nagel et al. [40] | 2003 | MRI | 38 | 5 | 37 | 4 | 88.4 | 90.2 | ≥75 % |
Paetsch et al. [41] | 2004 | MRI | 48 | 5 | 16 | 10 | 90.6 | 61.5 | >50 % |
Pilz et al. [42] | 2006 | MRI | 109 | 4 | 48 | 10 | 96.5 | 82.8 | >70 % |
Pingitore et al. [43] | 2008 | MRI | 61 | 5 | 18 | 9 | 92.4 | 66.7 | >50 % |
Plein et al. [44] | 2005 | MRI | 52 | 7 | 17 | 6 | 88.1 | 73.9 | >70 % |
Plein et al. [45] | 2008 | MRI | 31 | 4 | 7 | 9 | 88.6 | 43.8 | >50 % |
Plein et al. [46] | 2008 | MRI | 12 | 1 | 16 | 4 | 92.3 | 80.0 | >50 % |
Stolzmann et al. [47] | 2010 | MRI | 28 | 8 | 21 | 3 | 77.8 | 87.5 | >50 % |
Takase et al. [48] | 2004 | MRI | 71 | 5 | 22 | 4 | 93.4 | 84.6 | >50 % |
Aggeli et al. [49] | 2007 | ECHO | 28 | 4 | 16 | 2 | 87.5 | 88.9 | ≥50 % |
Arnold et al. [21] | 2010 | ECHO | 35 | 6 | 16 | 5 | 85.4 | 76.2 | ≥50 % |
Chiou et al. [50] | 2004 | ECHO | 69 | 16 | 36 | 11 | 81.2 | 76.6 | ≥50 % (≥40 % LM) |
Jeetley et al. [51] | 2006 | ECHO | 74 | 11 | 19 | 19 | 87.1 | 50.0 | ≥70 % |
Kowatsch et al. [52] | 2007 | ECHO | 22 | 3 | 21 | 8 | 88.0 | 72.4 | >50 % |
Lipiec et al. [53] | 2008 | ECHO | 69 | 10 | 18 | 6 | 87.3 | 75.0 | ≥70 % |
Miszalski-Jamka et al. [54] | 2009 | ECHO | 65 | 9 | 25 | 4 | 87.8 | 86.2 | ≥50 % |
Moir et al. [55] | 2005 | ECHO | 35 | 5 | 20 | 19 | 87.5 | 51.3 | ≥50 % |
Peltier et al. [56] | 2004 | ECHO | 22 | 0 | 10 | 3 | 100.0 | 76.9 | >70 % |
Senior et al. [57] | 2004 | ECHO | 35 | 7 | 7 | 5 | 83.3 | 58.3 | >50 % |
Aggeli et al. [49] | 2007 | SPECT | 24 | 6 | 17 | 1 | 80.0 | 94.4 | ≥50 % |
Astarita et al. [58] | 2001 | SPECT | 23 | 0 | 14 | 16 | 100.0 | 46.7 | ≥50 % |
Budoff et al. [59] | 2007 | SPECT | 17 | 4 | 7 | 2 | 81.0 | 77.8 | >70 % (>50 % LM) |
Doyle et al. [26] | 2003 | SPECT | 16 | 10 | 130 | 28 | 61.5 | 82.3 | ≥70 % |
Gonzalez et al. [60] | 2005 | SPECT | 102 | 15 | 16 | 12 | 87.2 | 57.1 | ≥50 % |
91 | 7 | 24 | 23 | 92.9 | 51.1 | ≥75 % | |||
Jeetley et al. [51] | 2006 | SPECT | 73 | 12 | 19 | 19 | 85.9 | 50.0 | ≥70 % |
Johansen et al. [61] | 2005 | SPECT | 94 | 32 | 183 | 48 | 74.6 | 79.2 | ≥50 % |
Lipiec et al. [53] | 2008 | SPECT | 73 | 6 | 13 | 11 | 92.4 | 54.2 | ≥70 % |
Peltier et al. [56] | 2004 | SPECT | 18 | 4 | 11 | 2 | 81.8 | 84.6 | >70 % |
Schepis et al. [62] | 2007 | SPECT | 32 | 10 | 32 | 3 | 76.2 | 91.4 | ≥50 % |
Senior et al. [57] | 2004 | SPECT | 20 | 21 | 11 | 1 | 48.8 | 91.7 | >50 % |
Yao et al. [63] | 2000 | SPECT | 42 | 3 | 18 | 1 | 93.3 | 94.7 | ≥50 % |
Yeih et al. [64] | 2007 | SPECT | 20 | 8 | 20 | 3 | 71.4 | 87.0 | ≥50 % |