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01.05.2013 | Breast

A novel functional infrared imaging system coupled with multiparametric computerised analysis for risk assessment of breast cancer

verfasst von: Tamar Sella, Miri Sklair-Levy, Maya Cohen, Mona Rozin, Myra Shapiro-Feinberg, Tanir M. Allweis, Eugene Libson, David Izhaky

Erschienen in: European Radiology | Ausgabe 5/2013

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Abstract

Objective

We evaluated a functional three-dimensional (3D) infrared imaging system (3DIRI) coupled with multiparametric computer analysis for risk assessment of breast cancer. The technique provides objective risk assessment for the presence of a malignant tumour based on automated parameters derived from a clinically known training set.

Methods

Following institutional review board approval, we recruited 434 women for this prospective multicentre trial, including 256 healthy woman undergoing routine screening mammography with BI-RADS-1 results and 178 women with newly diagnosed breast cancer. This was a two-phase study: an initial training and calibration phase, followed by a two-armed blinded evaluation phase (52 healthy and 66 with breast cancer). 3DIRI data sets were acquired using a non-contact, no radiation system.

Results

The sensitivity and specificity of functional infrared imaging in providing the correct risk for the presence of breast cancer were 90.9 % and 72.5 %, respectively. The area under the ROC curve was 86 %. Forty-two of the 60 (70 %) cancers in women correctly classified by the system as suspicious were smaller than 20 mm in size.

Conclusion

The preliminary blinded results of this novel technology show sufficient performance of functional infrared imaging in providing risk assessment for breast cancer to warrant further clinical studies.

Key Points

• 3D functional infrared imaging (3DIRI) provides new metabolic signatures from breast lesions.

• 3DIRI offers high sensitivity for risk assessment of breast cancer.

• It also has reasonable specificity.

• This initial experience warrants further evaluation in larger clinical trials.

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Titel: A novel functional infrared imaging system coupled with multiparametric computerised analysis for risk assessment of breast cancer
verfasst von: Tamar Sella
Miri Sklair-Levy
Maya Cohen
Mona Rozin
Myra Shapiro-Feinberg
Tanir M. Allweis
Eugene Libson
David Izhaky
Publikationsdatum: 01.05.2013
Verlag: Springer-Verlag
Erschienen in: European Radiology / Ausgabe 5/2013
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-012-2724-7

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A novel functional infrared imaging system coupled with multiparametric computerised analysis for risk assessment of breast cancer