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Erschienen in:
09.04.2018 | Head and Neck
MR-based radiomics signature in differentiating ocular adnexal lymphoma from idiopathic orbital inflammation
Erschienen in: European Radiology | Ausgabe 9/2018
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Objectives
To assess the value of the MR-based radiomics signature in differentiating ocular adnexal lymphoma (OAL) and idiopathic orbital inflammation (IOI).
Methods
One hundred fifty-seven patients with pathology-proven OAL (84 patients) and IOI (73 patients) were divided into primary and validation cohorts. Eight hundred six radiomics features were extracted from morphological MR images. The least absolute shrinkage and selection operator (LASSO) procedure and linear combination were used to select features and build radiomics signature for discriminating OAL from IOI. Discriminating performance was assessed by the area under the receiver-operating characteristic curve (AUC). The predictive results were compared with the assessment of radiologists by chi-square test.
Results
Five radiomics features were included in the radiomics signature, which differentiated OAL from IOI with an AUC of 0.74 and 0.73 in the primary and validation cohorts respectively. There was a significant difference between the classification results of the radiomics signature and those of a radiology resident (p < 0.05), although there was no significant difference between the results of the radiomics signature and those of a more experienced radiologist (p > 0.05).
Conclusions
Radiomics features have the potential to differentiate OAL from IOI.
Key Points
• Clinical and imaging findings of OAL and IOI often overlap, which makes diagnosis difficult.
• Radiomics features can potentially differentiate OAL from IOI non invasively.
• The radiomics signature discriminates OAL from IOI at the same level as an experienced radiologist.