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Erschienen in: European Archives of Oto-Rhino-Laryngology 12/2012

01.12.2012 | Review Article

Inflammatory myofibroblastic tumors of the head and neck: evaluation of clinicopathologic and prognostic features

verfasst von: Kenneth O. Devaney, Daniel J. LaFeir, Asterios Triantafyllou, William M. Mendenhall, Julia A. Woolgar, Alessandra Rinaldo, Alfio Ferlito

Erschienen in: European Archives of Oto-Rhino-Laryngology | Ausgabe 12/2012

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Abstract

Head and neck lesions composed of spindle cells evoke a differential diagnosis which includes a host of benign and malignant entities. One of the less common spindle cell lesions in this region is the inflammatory myofibroblastic tumor (IMT). Although IMTs were originally regarded as “pseudotumors”, they are now recognized to be true neoplasms. Local recurrence, and, rarely, malignant change have been reported. Currently, the definitive means of diagnosing IMTs is the identification of a rearrangement of the anaplastic lymphoma kinase gene (at chromosome 2p23) by fluorescence in situ hybridization. The histopathologic differential diagnosis includes infectious processes, other fibro-inflammatory lesions, lymphoma, the inflammatory variant of malignant fibrous histiocytoma, and sarcomatoid (spindle cell) carcinoma. Complete surgical excision is the treatment of choice.
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Metadaten
Titel
Inflammatory myofibroblastic tumors of the head and neck: evaluation of clinicopathologic and prognostic features
verfasst von
Kenneth O. Devaney
Daniel J. LaFeir
Asterios Triantafyllou
William M. Mendenhall
Julia A. Woolgar
Alessandra Rinaldo
Alfio Ferlito
Publikationsdatum
01.12.2012
Verlag
Springer-Verlag
Erschienen in
European Archives of Oto-Rhino-Laryngology / Ausgabe 12/2012
Print ISSN: 0937-4477
Elektronische ISSN: 1434-4726
DOI
https://doi.org/10.1007/s00405-012-2026-3

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