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European Spine Journal

Erschienen in:

01.02.2013 | Chinese section

Association of rs11190870 near LBX1 with adolescent idiopathic scoliosis susceptibility in a Han Chinese population

verfasst von: Hua Jiang, Xusheng Qiu, Jin Dai, Huang Yan, Zezhang Zhu, Bangping Qian, Yong Qiu

Erschienen in: European Spine Journal | Ausgabe 2/2013

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Abstract

Purpose

To investigate whether rs11190870 near LBX1 correlates with the susceptibility or curve progression of adolescent idiopathic scoliosis (AIS) in a Han Chinese population.

Methods

A total of 949 AIS patients and 976 age-matched healthy controls were recruited. All the subjects were genotyped using the PCR-based invader assay. Case–control study and case-only study were performed to define the contribution of rs11190870 to predisposition and curve severity of AIS. Additionally, we further conducted a meta-analysis of the study findings together with those of previously reported studies.

Results

A significant association of rs11190870 with AIS was observed in the Han Chinese population (P = 1.8 × 10⁻⁹; odd ratio = 1.51; 95 % confidence interval = 1.33–1.71), and AIS patients with TT genotype had a larger Cobb angle than those with TC or CC genotype (P = 0.005). The meta-analysis confirmed that the positive association of this SNP with AIS in the East Asian population.

Conclusions

The SNP rs11190870 near LBX1 is associated with both susceptibility and curve progression of AIS.

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Titel: Association of rs11190870 near LBX1 with adolescent idiopathic scoliosis susceptibility in a Han Chinese population
verfasst von: Hua Jiang
Xusheng Qiu
Jin Dai
Huang Yan
Zezhang Zhu
Bangping Qian
Yong Qiu
Publikationsdatum: 01.02.2013
Verlag: Springer-Verlag
Erschienen in: European Spine Journal / Ausgabe 2/2013
Print ISSN: 0940-6719
Elektronische ISSN: 1432-0932
DOI: https://doi.org/10.1007/s00586-012-2532-4

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