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01.09.2009 | Basic Neurosciences, Genetics and Immunology - Original Article

sPhospholipase A₂ is inhibited by anthocyanidins

verfasst von: Andrea Dreiseitel, Gabriele Korte, Peter Schreier, Anett Oehme, Sanja Locher, Goeran Hajak, Philipp G. Sand

Erschienen in: Journal of Neural Transmission | Ausgabe 9/2009

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Abstract

Epidemiological studies suggest that nutritional antioxidants may reduce the incidence of neurodegenerative disorders and age-related cognitive decline. Specifically, protection against oxidative stress and inflammation has served as a rationale for promoting diets rich in vegetables and fruits. The present study addresses secretory phospholipase A₂ (sPLA₂) as a novel candidate effector of neuroprotection conferred by anthocyanins and anthocyanidins. Using a photometric assay, 15 compounds were screened for their ability to inhibit PLA₂. Of these, cyanidin, malvidin, peonidin, petunidin, and delphinidin achieved K _i values ≤18 μM, suggesting a modulatory role for berry polyphenols in phospholipid metabolism.

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Titel: sPhospholipase A2 is inhibited by anthocyanidins
verfasst von: Andrea Dreiseitel
Gabriele Korte
Peter Schreier
Anett Oehme
Sanja Locher
Goeran Hajak
Philipp G. Sand
Publikationsdatum: 01.09.2009
Verlag: Springer Vienna
Erschienen in: Journal of Neural Transmission / Ausgabe 9/2009
Print ISSN: 0300-9564
Elektronische ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-009-0268-z

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sPhospholipase A₂ is inhibited by anthocyanidins

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