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Magnetic Resonance Materials in Physics, Biology and Medicine

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01.08.2014 | Research Article

Longitudinal sensitivity to change of MRI-based muscle cross-sectional area versus isometric strength analysis in osteoarthritic knees with and without structural progression: pilot data from the Osteoarthritis Initiative

verfasst von: Torben Dannhauer, Martina Sattler, Wolfgang Wirth, David J. Hunter, C. Kent Kwoh, Felix Eckstein

Erschienen in: Magnetic Resonance Materials in Physics, Biology and Medicine | Ausgabe 4/2014

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Abstract

Object

Biomechanical measurement of muscle strength represents established technology in evaluating limb function. Yet, analysis of longitudinal change suffers from relatively large between-measurement variability. Here, we determine the sensitivity to change of magnetic resonance imaging (MRI)-based measurement of thigh muscle anatomical cross sectional areas (ACSAs) versus isometric strength in limbs with and without structural progressive knee osteoarthritis (KOA), with focus on the quadriceps.

Materials and methods

Of 625 “Osteoarthritis Initiative” participants with radiographic KOA, 20 had MRI cartilage and radiographic joint space width loss in the right knee isometric muscle strength measurement and axial T1-weighted spin-echo acquisitions of the thigh. Muscle ACSAs were determined from manual segmentation at 33 % femoral length (distal to proximal).

Results

In progressor knees, the reduction in quadriceps ACSA between baseline and 2-year follow-up was −2.8 ± 7.9 % (standardized response mean [SRM] = −0.35), and it was −1.8 ± 6.8 % (SRM = −0.26) in matched, non-progressive KOA controls. The decline in extensor strength was more variable than that in ACSAs, both in progressors (−3.9 ± 20 %; SRM = −0.20) and in non-progressive controls (−4.5 ± 28 %; SRM = −0.16).

Conclusion

MRI-based analysis of quadriceps muscles ACSAs appears to be more sensitive to longitudinal change than isometric extensor strength and is suggestive of greater loss in limbs with structurally progressive KOA than in non-progressive controls.

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Titel: Longitudinal sensitivity to change of MRI-based muscle cross-sectional area versus isometric strength analysis in osteoarthritic knees with and without structural progression: pilot data from the Osteoarthritis Initiative
verfasst von: Torben Dannhauer
Martina Sattler
Wolfgang Wirth
David J. Hunter
C. Kent Kwoh
Felix Eckstein
Publikationsdatum: 01.08.2014
Verlag: Springer Berlin Heidelberg
Erschienen in: Magnetic Resonance Materials in Physics, Biology and Medicine / Ausgabe 4/2014
Print ISSN: 0968-5243
Elektronische ISSN: 1352-8661
DOI: https://doi.org/10.1007/s10334-013-0418-z

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Longitudinal sensitivity to change of MRI-based muscle cross-sectional area versus isometric strength analysis in osteoarthritic knees with and without structural progression: pilot data from the Osteoarthritis Initiative

Abstract

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Materials and methods

Results

Conclusion

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Springer Medizin

Abstract

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Materials and methods

Results

Conclusion

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