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Inflammation

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01.12.2014

Dual Effects of Respiratory Syncytial Virus Infections on Airway Inflammation by Regulation of Th17/Treg Responses in Ovalbumin-Challenged Mice

verfasst von: Jia Wang, Lingwen Kong, Qingli Luo, Bei Li, Jinfeng Wu, Baojun Liu, Xiao Wu, Jingcheng Dong

Erschienen in: Inflammation | Ausgabe 6/2014

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Abstract

We investigated the effects of respiratory syncytial virus (RSV) infections on ovalbumin (OVA)-challenged mice via regulation of Th17/Treg cell responses. BALB/c mice were challenged with OVA, followed by RSV infections twice. In OVA-challenged mice, the secretion of Th2/Th17-type cytokines, airway hyperresponsiveness and inflammation were significantly inhibited by initial RSV infection. Moreover, the in vivo findings demonstrated that initial RSV infection reversed the imbalance of Th17/Treg responses. In contrast, RSV re-infection strengthened Th2/Th17-type cytokine secretion, airway hyperresponsiveness, and inflammation, especially for lymphocyte infiltration in OVA-challenged mice. Meanwhile, RSV re-infection enhanced the imbalanced Th17/Treg responses. Upon all results reveal that RSV-induced respiratory infections may lead to dual effects pertaining to allergic airway inflammation by regulation of Th17/Treg responses.

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Titel: Dual Effects of Respiratory Syncytial Virus Infections on Airway Inflammation by Regulation of Th17/Treg Responses in Ovalbumin-Challenged Mice
verfasst von: Jia Wang
Lingwen Kong
Qingli Luo
Bei Li
Jinfeng Wu
Baojun Liu
Xiao Wu
Jingcheng Dong
Publikationsdatum: 01.12.2014
Verlag: Springer US
Erschienen in: Inflammation / Ausgabe 6/2014
Print ISSN: 0360-3997
Elektronische ISSN: 1573-2576
DOI: https://doi.org/10.1007/s10753-014-9931-0

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