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Metabolic Brain Disease

Erschienen in:

01.12.2014 | Original Paper

Magnetic resonance of the brain in chronic and acute liver failure

verfasst von: Laia Chavarria, Juan Cordoba

Erschienen in: Metabolic Brain Disease | Ausgabe 4/2014

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Abstract

Brain alterations such as hepatic encephalopathy or brain edema are usually associated with liver failure. The mechanisms that lead to the generation of edema seem to be different depending on the course of liver failure (acute, chronic or acute-on-chronic liver failure). Several neuroimaging methods allow a non-invasive assessment of brain alterations in liver failure. Magnetic resonance has gained more interest due to the ability of giving information about cerebral metabolism using spectroscopy, water distribution by diffusion methods or neuronal connectivity by means of resting state magnetic resonance. These techniques have been applied to experimental models and patients with liver failure to elucidate cerebral pathways involved in the pathogenesis of hepatic encephalopathy. In the future, the development of new magnetic resonance implementations will generate handy tools for the study of the brain and get better understanding of the mechanisms that take place in liver failure. This could be useful for the early diagnosis, as well as for the design of new treatments for cerebral complications of liver failure.

Aggarwal A, Vaidya S, Shah S, Singh J, Desai S, Bhatt M (2006) Reversible Parkinsonism and T1W pallidal hyperintensities in acute liver failure. Mov Disord 21:1986–1990PubMedCrossRef

Albers GW (1998) Diffusion-weighted MRI for evaluation of acute stroke. Neurology 51:S47–S49PubMedCrossRef

Ardenkjaer-Larsen JH, Fridlund B, Gram A, Hansson G, Hansson L, Lerche MH, Servin R, Thaning M, Golman K (2003) Increase in signal-to-noise ratio of >10,000 times in liquid-state NMR. Proc Natl Acad Sci U S A 100:10158–10163PubMedCentralPubMedCrossRef

Ashburner J, Friston KJ (2000) Voxel-based morphometry–the methods. Neuroimage 11:805–821PubMedCrossRef

Barba I, Chatauret N, Garcia-Dorado D, Cordoba J (2008) A 1H nuclear magnetic resonance-based metabonomic approach for grading hepatic encephalopathy and monitoring the effects of therapeutic hypothermia in rats. Liver Int 28:1141–1148PubMedCrossRef

Barbiroli B, Gaiani S, Lodi R, Iotti S, Tonon C, Clementi V, Donati G, Bolondi L (2002) Abnormal brain energy metabolism shown by in vivo phosphorus magnetic resonance spectroscopy in patients with chronic liver disease. Brain Res Bull 59:75–82PubMedCrossRef

Brand A, Richter-Landsberg C, Leibfritz D (1993) Multinuclear NMR studies on the energy metabolism of glial and neuronal cells. Dev Neurosci 15:289–298PubMedCrossRef

Broyd SJ, Demanuele C, Debener S, Helps SK, James CJ, Sonuga-Barke EJ (2009) Default-mode brain dysfunction in mental disorders: a systematic review. Neurosci Biobehav Rev 33:279–296PubMedCrossRef

Cauli O, Lopez-Larrubia P, Rodrigues TB, Cerdan S, Felipo V (2007) Magnetic resonance analysis of the effects of acute ammonia intoxication on rat brain. Role of NMDA receptors. J Neurochem 103:1334–1343PubMedCrossRef

Cauli O, Lopez-Larrubia P, Rodrigo R, Agusti A, Boix J, Nieto-Charques L, Cerdan S, Felipo V (2011) Brain region-selective mechanisms contribute to the progression of cerebral alterations in acute liver failure in rats. Gastroenterology 140:638–645PubMedCrossRef

Chavarria L, Oria M, Romero-Gimenez J, Alonso J, Lope-Piedrafita S, Cordoba J (2010) Diffusion tensor imaging supports the cytotoxic origin of brain edema in a rat model of acute liver failure. Gastroenterology 138:1566–1573PubMedCrossRef

Chavarria L, Alonso J, Garcia-Martinez R, Aymerich FX, Huerga E, Jacas C, Vargas V, Cordoba J, Rovira A (2011) Biexponential analysis of diffusion-tensor imaging of the brain in patients with cirrhosis before and after liver transplantation. AJNR Am J Neuroradiol 32:1510–1517PubMedCrossRef

Chavarria L, Oria M, Romero-Gimenez J, Alonso J, Lope-Piedrafita S, Cordoba J (2013) Brain magnetic resonance in experimental acute-on-chronic liver failure. Liver Int 33:294–300PubMedCrossRef

Chen HJ, Zhu XQ, Shu H, Yang M, Zhang Y, Ding J, Wang Y, Teng GJ (2012) Structural and functional cerebral impairments in cirrhotic patients with a history of overt hepatic encephalopathy. Eur J Radiol 81:2463–2469PubMedCrossRef

Chen HJ, Jiao Y, Zhu XQ, Zhang HY, Liu JC, Wen S, Teng GJ (2013) Brain dysfunction primarily related to previous overt hepatic encephalopathy compared with minimal hepatic encephalopathy: resting-state functional MR imaging demonstration. Radiology 266:261–270PubMedCrossRef

Cordoba J, Gottstein J, Blei AT (1996) Glutamine, myo-inositol, and organic brain osmolytes after portocaval anastomosis in the rat: implications for ammonia-induced brain edema. Hepatology 24:919–923PubMed

Cordoba J, Alonso J, Rovira A, Jacas C, Sanpedro F, Castells L, Vargas V, Margarit C, Kulisewsky J, Esteban R, Guardia J (2001) The development of low-grade cerebral edema in cirrhosis is supported by the evolution of (1)H-magnetic resonance abnormalities after liver transplantation. J Hepatol 35:598–604PubMedCrossRef

Cudalbu C, Lanz B, Duarte JM, Morgenthaler FD, Pilloud Y, Mlynarik V, Gruetter R (2012) Cerebral glutamine metabolism under hyperammonemia determined in vivo by localized (1)H and (15)N NMR spectroscopy. J Cereb Blood Flow Metab 32:696–708PubMedCentralPubMedCrossRef

Filippi M, Rocca MA, De SN, Enzinger C, Fisher E, Horsfield MA, Inglese M, Pelletier D, Comi G (2011) Magnetic resonance techniques in multiple sclerosis: the present and the future. Arch Neurol 68:1514–1520PubMedCrossRef

Garcia-Martinez R, Rovira A, Alonso J, Jacas C, Simon-Talero M, Chavarria L, Vargas V, Cordoba J (2011) Hepatic encephalopathy is associated with posttransplant cognitive function and brain volume. Liver Transpl 17:38–46PubMedCrossRef

Govindaraju V, Young K, Maudsley AA (2000) Proton NMR chemical shifts and coupling constants for brain metabolites. NMR Biomed 13:129–153PubMedCrossRef

Gruetter R, Novotny EJ, Boulware SD, Rothman DL, Mason GF, Shulman GI, Shulman RG, Tamborlane WV (1992) Direct measurement of brain glucose concentrations in humans by 13C NMR spectroscopy. Proc Natl Acad Sci U S A 89:1109–1112PubMedCentralPubMedCrossRef

Guevara M, Baccaro ME, Gomez-Anson B, Frisoni G, Testa C, Torre A, Molinuevo JL, Rami L, Pereira G, Sotil EU, Cordoba J, Arroyo V, Gines P (2011) Cerebral magnetic resonance imaging reveals marked abnormalities of brain tissue density in patients with cirrhosis without overt hepatic encephalopathy. J Hepatol 55:564–573PubMedCrossRef

Gusnard DA, Raichle ME, Raichle ME (2001) Searching for a baseline: functional imaging and the resting human brain. Nat Rev Neurosci 2:685–694PubMedCrossRef

Iwasa M, Mifuji-Moroka R, Kuroda M, Moroka H, Fujita N, Kobayashi Y, Adachi Y, Gabazza EC, Matsuda H, Takei Y (2012) Regional reduction in gray and white matter volume in brains of cirrhotic patients: voxel-based analysis of MRI. Metab Brain Dis 27:551–557PubMedCrossRef

Jalan R, Olde Damink SW, Hayes PC, Deutz NE, Lee A (2004) Pathogenesis of intracranial hypertension in acute liver failure: inflammation, ammonia and cerebral blood flow. J Hepatol 41:613–620PubMedCrossRef

Kale RA, Gupta RK, Saraswat VA, Hasan KM, Trivedi R, Mishra AM, Ranjan P, Pandey CM, Narayana PA (2006) Demonstration of interstitial cerebral edema with diffusion tensor MR imaging in type C hepatic encephalopathy. Hepatology 43:698–706PubMedCrossRef

Karas GB, Scheltens P, Rombouts SA, Visser PJ, van Schijndel RA, Fox NC, Barkhof F (2004) Global and local gray matter loss in mild cognitive impairment and Alzheimer’s disease. Neuroimage 23:708–716PubMedCrossRef

Kumamoto T, Takeda K, Ishibe A, Morioka D, Matsuo K, Tanaka K, Endo I, Sekido H, Togo S, Shimada H (2009) Complete neurological recovery from fulminant hepatic failure with subarachnoid hemorrhage by living donor liver transplantation: a case report. Transplant Proc 41:1982–1986PubMedCrossRef

Laleman W, Verbeke L, Meersseman P, Wauters J, van Pelt J, Cassiman D, Wilmer A, Verslype C, Nevens F (2011) Acute-on-chronic liver failure: current concepts on definition, pathogenesis, clinical manifestations and potential therapeutic interventions. Expert Rev Gastroenterol Hepatol 5:523–537PubMedCrossRef

LeBihan D, Mangin JF, Poupon C, Clark CA, Pappata S, Molko N, Chabriat H (2001) Diffusion tensor imaging: concepts and applications. J Magn Reson Imaging 13:534–546CrossRef

Lei H, Zhu XH, Zhang XL, Ugurbil K, Chen W (2003) In vivo 31P magnetic resonance spectroscopy of human brain at 7T: an initial experience. Magn Reson Med 49:199–205PubMedCrossRef

Lodi R, Tonon C, Stracciari A, Weiger M, Camaggi V, Iotti S, Donati G, Guarino M, Bolondi L, Barbiroli B (2004) Diffusion MRI shows increased water apparent diffusion coefficient in the brains of cirrhotics. Neurology 62:762–766PubMedCrossRef

Loubinoux I, Volk A, Borredon J, Guirimand S, Tiffon B, Seylaz J, Meric P (1997) Spreading of vasogenic edema and cytotoxic edema assessed by quantitative diffusion and T2 magnetic resonance imaging. Stroke 28:419–426PubMedCrossRef

Mandal PK (2007) Magnetic resonance spectroscopy (MRS) and its application in Alzheimer’s disease. Concepts Magn Reson 30A:40–64CrossRef

Matthews PM, Jezzard P (2004) Functional magnetic resonance imaging. J Neurol Neurosurg Psychiatry 75:6–12PubMedCentralPubMed

Miese FR, Wittsack HJ, Kircheis G, Holstein A, Mathys C, Modder U, Cohnen M (2009) Voxel-based analyses of magnetization transfer imaging of the brain in hepatic encephalopathy. World J Gastroenterol 15:5157–5164PubMedCentralPubMedCrossRef

Nath K, Saraswat VA, Krishna YR, Thomas MA, Rathore RK, Pandey CM, Gupta RK (2008) Quantification of cerebral edema on diffusion tensor imaging in acute-on-chronic liver failure. NMR Biomed 21:713–722PubMedCrossRef

Pellerin L, Bouzier-Sore AK, Aubert A, Serres S, Merle M, Costalat R, Magistretti PJ (2007) Activity-dependent regulation of energy metabolism by astrocytes: an update. Glia 55:1251–1262PubMedCrossRef

Polson J, Lee WM (2005) AASLD position paper: the management of acute liver failure. Hepatology 41:1179–1197PubMedCrossRef

Poveda MJ, Bernabeu A, Concepcion L, Roa E, de Madaria E, Zapater P, Perez-Mateo M, Jover R (2010) Brain edema dynamics in patients with overt hepatic encephalopathy A magnetic resonance imaging study. Neuroimage 52:481–487PubMedCrossRef

Rai V, Nath K, Saraswat VA, Purwar A, Rathore RK, Gupta RK (2008) Measurement of cytotoxic and interstitial components of cerebral edema in acute hepatic failure by diffusion tensor imaging. J Magn Reson Imaging 28:334–341PubMedCrossRef

Ranjan P, Mishra AM, Kale R, Saraswat VA, Gupta RK (2005) Cytotoxic edema is responsible for raised intracranial pressure in fulminant hepatic failure: in vivo demonstration using diffusion-weighted MRI in human subjects. Metab Brain Dis 20:181–192PubMedCrossRef

Rose C, Butterworth RF, Zayed J, Normandin L, Todd K, Michalak A, Spahr L, Huet PM, Pomier-Layrargues G (1999) Manganese deposition in basal ganglia structures results from both portal-systemic shunting and liver dysfunction. Gastroenterology 117:640–644PubMedCrossRef

Rovira A, Cordoba J, Sanpedro F, Grive E, Rovira-Gols A, Alonso J (2002) Normalization of T2 signal abnormalities in hemispheric white matter with liver transplant. Neurology 59:335–341PubMedCrossRef

Saksena S, Rai V, Saraswat VA, Rathore RS, Purwar A, Kumar M, Thomas MA, Gupta RK (2008) Cerebral diffusion tensor imaging and in vivo proton magnetic resonance spectroscopy in patients with fulminant hepatic failure. J Gastroenterol Hepatol 23:e111–e119PubMedCrossRef

Shah NJ, Neeb H, Kircheis G, Engels P, Haussinger D, Zilles K (2008) Quantitative cerebral water content mapping in hepatic encephalopathy. Neuroimage 41:706–717PubMedCrossRef

Sijens PE, Alkefaji H, Lunsing RJ, van Spronsen FJ, Meiners LC, Oudkerk M, Verkade HJ (2008) Quantitative multivoxel 1H MR spectroscopy of the brain in children with acute liver failure. Eur Radiol 18:2601–2609PubMedCrossRef

Torisu S, Washizu M, Hasegawa D, Orima H (2005) Brain magnetic resonance imaging characteristics in dogs and cats with congenital portosystemic shunts. Vet Radiol Ultrasound 46:447–451

Verma A, Saraswat VA, Radha KY, Nath K, Thomas MA, Gupta RK (2008) In vivo 1H magnetic resonance spectroscopy-derived metabolite variations between acute-on-chronic liver failure and acute liver failure. Liver Int 28:1095–1103PubMedCrossRef

Wright G, Davies NA, Shawcross DL, Hodges SJ, Zwingmann C, Brooks HF, Mani AR, Harry D, Stadlbauer V, Zou Z, Williams R, Davies C, Moore KP, Jalan R (2007) Endotoxemia produces coma and brain swelling in bile duct ligated rats. Hepatology 45:1517–1526PubMedCrossRef

Wright G, Vairappan B, Stadlbauer V, Mookerjee RP, Davies NA, Jalan R (2012) Reduction in hyperammonaemia by ornithine phenylacetate prevents lipopolysaccharide-induced brain edema and coma in cirrhotic rats. Liver Int 32:410–419PubMed

Zhang L, Qi R, Wu S, Zhong J, Zhong Y, Zhang Z, Zhang Z, Lu G (2012a) Brain default-mode network abnormalities in hepatic encephalopathy: a resting-state functional MRI study. Hum Brain Mapp 33:1384–1392PubMedCrossRef

Zhang LJ, Qi R, Zhong J, Xu Q, Zheng G, Lu GM (2012b) The effect of hepatic encephalopathy, hepatic failure, and portosystemic shunt on brain volume of cirrhotic patients: a voxel-based morphometry study. PLoS One 7:e42824PubMedCentralPubMedCrossRef

Zwingmann C, Chatauret N, Leibfritz D, Butterworth RF (2003) Selective increase of brain lactate synthesis in experimental acute liver failure: results of a [H-C] nuclear magnetic resonance study. Hepatology 37:420–428PubMedCrossRef

Titel: Magnetic resonance of the brain in chronic and acute liver failure
verfasst von: Laia Chavarria
Juan Cordoba
Publikationsdatum: 01.12.2014
Verlag: Springer US
Erschienen in: Metabolic Brain Disease / Ausgabe 4/2014
Print ISSN: 0885-7490
Elektronische ISSN: 1573-7365
DOI: https://doi.org/10.1007/s11011-013-9452-9

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