Introduction
A chronic, immune-mediated skin disease, plaque psoriasis (PsO) is the most common form of psoriasis and can result in raised, red, silver, or flaky patches on the skin. Affecting 1–3% of the world’s population, PsO is associated with significant disease burden, including poor quality of life (QoL), increased disability, social stigmatization, and decreased emotional and physical well-being [
1‐
3]. In addition, PsO is linked to co-morbidities including psoriatic arthritis (PsA), obesity, diabetes mellitus, and cardiovascular disease [
1‐
3]. Long-term management of PsO is essential for improving quality of life and lessening the burden of comorbid conditions. While mild disease is often controlled with topical agents, systemic therapy is often used to treat patients with moderate to severe disease, defined as involvement of 3–10 and greater than 10 percent of the body surface area (BSA), respectively [
3]. Traditional systemic drugs include methotrexate, cyclosporine, and acitretin. More recently, a multitude of biologic therapies have been approved for PsO. Biologic and non-biologic therapies vary widely in their benefit/risk profiles, as well as in other aspects related to convenience.
Evidence is now accumulating that, to optimize patient outcomes, there should be a shared decision-making process between patients and physicians [
1]. Patients are heterogenous in terms of how PsO manifests, how severe it is, how much it impacts their lives, and what their specific treatment goals may be. To this end, American Academy of Dermatology (AAD) guidelines recommend tailoring treatment choices to the individual patient [
4]. Ultimately, understanding patient attitudes and preferences for treatment attributes can lead to greater treatment satisfaction, treatment adherence and compliance, and better long-term outcomes [
5‐
8].
For patients with moderate to severe psoriasis, data is accumulating on treatment preferences and expectations. The largest and most complete data sets from the German Psoriasis (PsoBest) and Swiss Dermatology Network of Targeted Therapies (SDNTT) registries highlight the value of obtaining completely clear skin and rapid onset for patients [
9,
10]. Because treatment decisions or changes are likely to occur when patients do not have adequate disease control, the objectives of this study are to expand on previous findings and provide clinicians insights into the treatment preferences and disease burden of patients who are still impacted by PsO and are dissatisfied with their current therapy.
Methods
Study Design and Participants
This study was executed as a cross-sectional online quantitative survey targeting adult patients (n = 500) with moderate to severe PsO in the USA. Patient inclusion criteria were adult patients with moderate to severe PsO (self-assessed based on BSA ≥ 3), current or previous use of systemic therapy within the past 12 months (non-biologic and biologic systemic therapies), and a score of 7–10 (on a 10-point scale) for at least one of the following questions: Agreement on “I want a medication that clears my skin more effectively” or “I miss out on aspects of my life because of psoriasis”. Any respondent aged 75 or older or who was working for a pharmaceutical, health insurance, research, or advertising company was excluded as there may be self-presentation effects that could alter the interview answers. Medical professionals were also excluded as the intent was to obtain purely a patient perspective. Furthermore, any respondent unwilling or unable to provide informed consent was excluded from this study.
The study (Protocol #18-045418) was approved by Pearl Institutional Review Board (IRB) and met the standards of both Food and Drug Administration (FDA) 21 Council of Federal Regulations (CFR) 56.104 and Department of Health and Human Services (DHHS) 45 CFR 46.101 regulations. Informed consent was obtained from all participants prior to participating in the study. This study was conducted in full conformance with the Guidelines for Good Pharmacoepidemiology Practices (GPP) published by the International Society of Pharmacoepidemiology (ISPE) and the laws and regulations of the country in which the research was conducted.
The survey was executed between December 2018 and January 2019. Potential respondents were recruited from various internet patient panels to participate in the cross-sectional online survey, approximately 20 min in duration. The interview request included a statement of informed consent and a set of screening questions based on the inclusion/exclusion criteria. The respondent could choose to quit the survey at any point without penalty. Upon completion of the survey, they were compensated through their panel in the form of “points”, equivalent to $10–15 USD, which can be redeemed for goods or the participant would be entered into a raffle.
Survey and Measures
Development of the survey content was facilitated by initial qualitative interviews conducted among 12 patients with moderate to severe PsO, approximately 45 min in length in September 2018. These interviews were exploratory tele-interviews in the USA which evaluated how PsO affects patients’ lives, and what great medication results look like from a patient’s perspective.
The final survey collected demographic information (including age, gender, race, gender, ethnicity, height/weight, employment status, and smoking history), disease characteristics, treatment use, and QoL. Disease characteristics included self-assessed BSA involvement, self-assessed severity, psoriasis location, and patient global assessment of genital PsO.
Self-assessed BSA involvement was measured by the number of palms that covered the patches on the body, 3–10 representing moderate disease severity and more than 10 classified as severe disease [
11]. Overall disease severity was also assessed using a self-reported rating scale of 0 (no PsO) to 100 (severe PsO) and genital PsO severity was assessed on a scale of 0 (clear, no PsO) to 5 (severe, the worse PsO). Psoriasis Skin Appearance Bothersomeness (PSAB), a validated tool on a scale of 0–10 in which in 0 is “not at all bothered” and 10 is “extremely bothered”, was used to determine the current extent of symptoms bothering the patients. Each of the symptoms (redness/discoloration, thickness, and scaling/flaking) was queried separately on a scale of 0–10. The three-item scores were summed for a total score ranging from 0 to 30 with higher scores indicating more bothersomeness due to skin appearance [
12]. Current symptom assessments of skin pain (in the past week, on the visual analogue scale (VAS) 0–100, 0 being none and 100 being worst), itch (in the past 24 h was assessed using Itch Numeric Rating Scale (Itch NRS) 0–10, 0 being no itch and 10 being worst imaginable itch), and fatigue (in the past week, on VAS 0–100, 0 being none and 100 being worst) were also collected [
13‐
16]. Patients’ current use of non-biologic (methotrexate, cyclosporine) and biologic systemic agents (tumor necrosis factor (TNFs), interleukin (IL)-17s, IL-12/23 s, IL-23, apremilast) was also collected.
Quality of life was captured using Dermatology Life Quality Index (DLQI, 0–30), with a recall period of 1 week. DLQI is a highly cited validated 10-question assessment of the effect of the patient’s dermatologic condition on QoL, with the following categories for scores: 0–1 (none), 2–5 (small), 6–10 (moderate), 11–20 (very large), and 21–30 (extremely large) for impact on QoL [
17].
Patients’ Goals for New Treatment
The importance of treatment attributes was captured on a scale of 0–10, where 0 is not at all important and 10 is extremely important. Attributes assessed included probability of side effects, overall effectiveness (achieving clear skin), rapidity of response, overall relief of symptoms (e.g., itching and skin pain), sustained response for longer time periods (2–3 years), and effectiveness in clearing certain hard-to-treat areas (i.e., nail, scalp, genitals, palms, and soles). A set of novel questions were designed to understand patient expectations for onset of efficacy as a treatment attribute. Specifically, patients were asked to report how many days they expect to see a 50% improvement or 100% improvement in their PsO, respectively.
Statistical Analysis
Descriptive analyses were conducted to describe the patient sample with respect to patient demographics, disease characteristics, treatment use, and treatment goals/expectations. Frequencies and percentages were reported for categorical outcomes and means, standard deviations (SD), medians and first and third quartiles were reported for continuous outcomes. Descriptive statistics were used to inform the exact variables in the multivariable logistic regression model.
A multivariate logistic regression model was conducted to examine the impact of different factors on patient preferences towards treatment goals. The dependent variable (patient preference towards each of the treatment goals) was defined as those who had high preference (a score of at least 7 on a 0–10 scale, 0 being low importance and 10 being high importance) vs. those who had low preference to the treatment goals. Age, gender, disease duration, and biologic experience were included as a priori independent covariates in the models. The final models were assessed for parsimony using the Akaike information criterion (AIC), area under the curve (AUC), and a pseudo r2. Independent variables (IVs) that did not add enough information to the final models were considered for removal to keep the number of IVs minimal while still ensuring a strong model fit. The final model was presented as parameter estimates with standard errors and Z scores. Odds ratios (OR) and confidence intervals (CI) were also presented. The overall model X2 was presented along with the AUC and final pseudo r2 values. Models were run for the following dependent (outcome) variables: “rapid response”, “keeping skin clear for 2–3 years”, “overall relief of symptoms”, and “effective in clearing in certain areas like nail, scalp, genitals, palms, and soles”, after adjusting for the a priori covariates mentioned above.
In addition to the multivariate analyses, descriptive analyses on different subgroups of interest were also performed for gender (male vs. female), age groups (18–30, 31–40, 41–50. and 51+), disease severity (moderate vs. severe), comorbid PsA (PsO only vs. PsO + PsA), location of PsO (trunk, extremities, palms/soles, nails, scalp, genitals, face, ears, and other) and biologic experience (biologic-naïve vs. biologic-experienced) to assess if the treatment goals and expectations were different between these subgroups.
All analyses were conducted using statistical analysis software (SAS, Cary, NC) v9.4 or R v3.4. On the basis of the programming of the survey all relevant questions required a response, though options for “unknown” or “decline to answer” (or similar values as appropriate for the specific question) were available. As a result, missing data was kept to a minimum. Missing responses were reported as such. For instances in which missing data were observed for an explanatory variable, the explanatory variable was coded in such a way as to combine with the separate category of “unknown/missing.” Missing data for an outcome variable was addressed using case-wise deletion; no imputation strategy was used.
Discussion
Recent research and guidelines indicate that considering the patient perspective in treatment decisions is essential to improve treatment satisfaction, adherence, and to achieve optimal patient outcomes [
5‐
8]. In this study, our goal was to provide clinicians with important information on the patient perspective when facing a treatment change decision. To this end, our study included patients who were not satisfied with the current level of disease control and wanted to consider a new treatment option, and we reported not only the treatment preferences and expectations for these patients but also the current burden of their symptoms and impact on their QoL.
Overall, the patient population in this study was similar to those in previous studies examining patient preferences and treatment goals in terms of disease severity and impact on QoL [
2,
18]. The patients with psoriasis in this study were slightly younger (39.9 years), had a shorter mean disease duration (8.7 years), slightly lower BMI (27.5 kg/m
2), and the majority were female (54%) when compared to patients from a study using the PsoBest registry (47.2 years, 18.3 years, 28.4 kg/m
2, and 40.40%, respectively) [
5], which is a German PsO registry that assesses long-term efficacy, safety, patient benefit, and treatment regimens of PsO. In addition, mean age and BMI among patients with psoriasis in this study were also lower than those in a study using a pool of PsoBest and SDNTT registry patients (47.6 years and 28.4 kg/m
2, respectively) [
19]. In our study, self-assessment of BSA revealed that 72% and 28% of patients in this study had moderate (BSA 3–10) and severe PsO (BSA > 10), comparable to other studies examining treatment goals among patients with PsO (mean Psoriasis Area and Severity Index (PASI) score of 14.5 indicating moderate to severe disease severity [
5] and 53.5% of patients with moderate/severe disease in the Japanese study [
20]. A higher percentage of patients were biologic-experienced, with 69.6% of the patients in this sample having any biologic experience. Interestingly, approximately 25% of patients reported PsO on the genitalia, consistent with other reports [
18,
21‐
26].
Despite consisting primarily of patients with moderate disease, this patient population experienced a particularly high impact on QoL (as measured by DLQI) and symptom burden, including itch, skin pain, fatigue, and PSAB, a finding that is consistent with other studies [
5,
19]. While this study did not directly measure PsO severity using PASI, it did assess bothersomeness of current PsO symptoms using PSAB, which indicated great bothersomeness of current PsO symptoms with a mean score of 23.5 (out of 30 maximum). A greater percentage of patients with PsO in this study were observed to have PsA (48%) compared to the study with pooled patients from PsoBest and SDNTT registries (19.1%), as well as patients in the PsoBest registry (22%) alone [
5,
19]. Furthermore, the patients in this study had considerable involvement of hard-to-treat areas (palms/soles, scalp, genitals), and QoL was found to be significantly impacted, with a mean DLQI score of 18.3, which is higher compared to the studies from PsOBest and SDNTT (mean DLQI of 11.3) [
5,
19].
In our study, patients placed high importance of a new treatment’s overall efficacy and safety while considering a new treatment (94% and 82.6%, respectively), consistent with other studies wherein treatment efficacy was valued higher than the treatment safety among the patients [
15,
27]. At least 90% of patients valued “rapid response where you can see that the medication is clearing skin quickly”, “keeping skin clear for 2–3 years”, and “overall relief of symptoms (e.g., itching and skin pain)”. Overall this data is consistent with previous reports (PsOBest and SDNTT) [
5,
19].
On the basis of our knowledge, this is the first study to understand what “rapid” means in terms of treatment expectations, with patients reporting that approximately 2 weeks as an expectation for achieving a 50% improvement in skin and approximately 4 weeks to achieve completely clear skin. There were certain numerical differences among the different subgroups analyzed, with younger age groups expecting response sooner than the older age groups and quite interestingly patients with moderate disease expecting a much faster response compared to patients with severe disease. Previous research has indicated that even residual disease can have a meaningful impact on QoL [
28]. The data from this study may suggest that patients with moderate PsO who experience recurrence have a stronger desire to achieve clear skin more quickly compared to patients with severe PsO.
One of the strengths of this study is the high number of respondents, the largest in the USA evaluating treatment goals among the patients. Additionally, the study did a comprehensive assessment of disease burden and also administered novel questions on treatment preferences, allowing for a comprehensive assessment of treatment goals and expectations. However, limitations should be noted and include the nature of the sample, as patients were recruited from an online panel, which may not be representative of the overall population of patients with PsO in the USA. This data may also not reflect the beliefs of patients who are not Caucasian or from countries other than the USA. There was also no comparison group in the study and the symptoms and severity levels were self-reported by the patients, which can lead to subjective responses leading to biased estimates. However, findings from this study provide insights for dermatologists into patient preferences toward treatment goals among patients who are unsatisfied with their current treatment and looking for a treatment change.
Acknowledgements
We would like to acknowledge and thank all study participants.
Disclosures
Joe Gorelick has had a financial agreement or affiliation with the following commercial interests as a consultant for AbbVie Pharmaceuticals, Dermira, Lilly, LEO, Novartis Pharmaceuticals, Ortho Dermatologics, Pfizer, PruGen, Regeneron Pharmaceuticals, Sanofi Genzyme, Sun Pharma, and UCB; served on Advisory Board/Speaker’s Bureau for AbbVie Pharmaceuticals, Dermira, Lilly, LEO Pharma, Novartis Pharmaceuticals, Ortho Dermatologics, Pfizer, PruGen, Regeneron Pharmaceuticals, Sun Pharma, and UCB. David Rosmarin has received honoraria as a consultant for AbbVie, Celgene, Dermavant, Dermira, Janssen, Lilly, Novartis, Pfizer, Regeneron, and Sanofi; has received research support from AbbVie, Bristol Meyers Squibb, Celgene, Dermira, Incyte, Janssen, Lilly, Merck, Novartis, Pfizer, and Regeneron Pharmaceuticals Inc; and has served as a paid speaker for AbbVie, Celgene, Janssen, Lilly, Novartis, Pfizer, Regeneron Pharmaceuticals Inc., and Sanofi. David Shrom is a current employee and shareholder of Eli Lilly and Company. Kiran Sikand is a current employee and shareholder of Eli Lilly and Company. Lisa Renda is a current employee and shareholder of Eli Lilly and Company. Russel Burge is a current employee and shareholder of Eli Lilly and Company. Craig Krebsbach is a current employee of Ipsos Insights LLC. Christine Dworkin was an employee of Ipsos Insights LLC at the time of the study. Chitra Karki was an employee of Ipsos Insights LLC at the time of the study. Ripsi P. Patel was an employee of Ipsos Insights LLC at the time of the study.