Background
Methods
Database
Ethics statement
Study setting and population
Inclusion criteria
Definition of patients with non-infection caused urticaria
Definition of patients with major depression
Exclusion criteria
Quality control for potential icd-9 over coding and treatments
Study protocol
Data analysis
Results
Demographics of patients with non-infection caused urticaria
Adolescents with non-infection caused urticaria (n = 5,755) | Control patients (n = 17,265) | ||||
---|---|---|---|---|---|
No. | % | No. | % |
p-value | |
Gender | 1.000 | ||||
Male | 2,657 | 46.2 | 7,971 | 46.2 | |
Female | 3,098 | 53.8 | 9,294 | 53.8 | |
Mean age (y/o) (Mean ± SD) | 16.2 ± 1.7 | 16.2 ± 1.7 | 1.000 | ||
Age group (y/o) | 1.000 | ||||
13-15 | 2,645 | 46 | 7,935 | 46 | |
16-18 | 3,110 | 54 | 9,330 | 54 | |
Economic level of family (monthly income) (USD$) | 0.246 | ||||
<600 | 1,622 | 28.2 | 4,737 | 27.4 | |
601 ~ 1,000 | 3,125 | 54.3 | 9,349 | 54.2 | |
>1,000 | 1,008 | 17.5 | 3,179 | 18.4 | |
Urbanization | 0.622 | ||||
1 (most) | 1,313 | 22.8 | 4,068 | 23.6 | |
2 | 703 | 12.2 | 2,102 | 12.2 | |
3 | 1,783 | 31 | 5,225 | 30.3 | |
4 | 1,956 | 34 | 5,870 | 34 | |
Geographic regions of Taiwan* | 0.036 | ||||
Northern | 2,659 | 46.2 | 8,105 | 46.9 | |
Central | 1,371 | 23.8 | 4,306 | 24.9 | |
Southern | 1,553 | 27 | 4,401 | 25.5 | |
Eastern | 172 | 3 | 453 | 2.6 | |
Asthma history* | 0.004 | ||||
Yes | 2,144 | 37.3 | 6,093 | 35.3 | |
No | 3,611 | 62.7 | 11,172 | 64.7 | |
Atopic dermatitis history* | <0.001 | ||||
Yes | 394 | 6.8 | 771 | 4.5 | |
No | 5,361 | 93.2 | 16,494 | 95.5 | |
Allergic rhinitis* | <0.001 | ||||
Yes | 2,886 | 50.1 | 8,068 | 46.7 | |
No | 2,869 | 49.9 | 9,197 | 53.3 | |
Family history of affective disorders | 339 | 5.9 | 932 | 5.4 | 0.151 |
Depression likelihood based on the crude HR
Pharmacological treatment (corticosteroids)
Variables | Occurrence of new-onset major depression | |
---|---|---|
HR | 95% CI | |
Adolescents with non-infection caused urticaria | 1.73 | 1.13-2.64 |
Control* | 1.00 | 1.00 |
Mode 1 | ||
Adolescents with non-infection caused urticaria | 1.72 | 1.13-2.63 |
Control* | 1.00 | 1.00 |
Mode 2 | ||
Adolescents with non-infection caused urticaria | 1.71 | 1.12-2.61 |
Control* | 1.00 | 1.00 |
Mode 3 | ||
Adolescents with non-infection caused urticaria | 1.85 | 1.17-2.93 |
Control* | 1.00 | 1.00 |
Mode 4 | ||
Adolescents with non-infection caused urticaria | 1.89 | 1.23-2.87 |
Control* | 1.00 | 1.00 |
Characteristics that are associated with the occurrence of new-onset major depression in patients with non-infection caused urticaria (n = 5,755)
Adolescents with non-infection caused urticaria (n = 5,755) | Control patients (n = 17,265) | |||
---|---|---|---|---|
New-onset major depression occurrence (n = 34) No. (%) | p –value | New-onset major depression occurrence (n = 59) No. (%) | p –value | |
Gender | ||||
Male | 15 (44.1) | 0.475 | 22 (37.3) | 0.192 |
Female | 19 (55.9) | 37 (62.7) | ||
Age group (y/o)* | ||||
13-15 | 8 (23.5) | 0.006 | 19 (32.2) | 0.037 |
16 ~ 18 | 26 (76.5) | 40 (67.8) | ||
Economic level of family (monthly income) (USD$) | ||||
<600 | 15 (44.1) | 0.095 | 21 (35.6) | 0.264 |
601 ~ 1,000 | 13 (38.2) | 26 (44.1) | ||
>1,000 | 6 (17.6) | 12 (20.3) | ||
Urbanization | ||||
1 (most) | 5 (14.7) | 0.251 | 14 (23.7) | 0.123 |
2 | 7 (20.6) | 3 (5.1) | ||
3 | 13 (38.2) | 25 (42.4) | ||
4 | 9 (26.5) | 17 (28.8) | ||
Geographic regions of Taiwan | ||||
Northern | 15 (44.1) | 0.660 | 27 (45.8) | 0.543 |
Central | 11 (32.4) | 12 (20.3) | ||
Southern | 7 (20.6) | 17 (28.3) | ||
Eastern | 1 (2.9) | 3 (5.1) | ||
Asthma history* | 19 (55.9) | 0.020 | 23 (39.0) | 0.589 |
Atopic dermatitis history | 3 (8.8) | 0.415 | 4 (6.8) | 0.337 |
Allergic rhinitis | 16 (47.1) | 0.425 | 28 (47.5) | 1.000 |
Family history of affective disorders* | 27 (79.4) | 0.002 | 43 (72.9) | 0.003 |
Urticaria treatment with corticosteroids* | 31 (91.1) | <0.001 | - | |
Mean number of hospital visits (to treat urticaria) | 1.6 ± 1.2 | 0.578 | - |