Background
Methods
Patients
CLN number | FNAB-C | FNAB-Tgp (ng/FNAB) | FNAB-Tgm | FNAB-CTm | Histology |
---|---|---|---|---|---|
1
| IN | 6620 | + | - | Met. PTC |
2
| IN | 7480 | + | - | Met. PTC |
3
| Met. PTC | 5652 | + | - | Met. PTC |
4*
| Met. PTC | 5293 | + | - | Met. PTC |
5*
| Met. PTC | 18612 | + | - | Met. PTC |
6
| Met. PTC | 1625 | + | - | Met. PTC |
7
| Met. MTC | 0.9 | - | + | Met. MTC |
8*
| IN | 37.50 | IN | IN | Met. PTC |
9
| Met. PTC | 26108 | + | - | Met. PTC |
10
| Met. ATC | UND | + | - | Met. ATC |
11
| Met. PTC | 37250 | ND | ND | Met. PTC |
12
| Met. PTC | 0.8 | + | - | Met. ATC |
13
| Met. PTC | 2.82 | - | - | Met. ATC |
14*
| Met. PTC | 114 | + | - | Met. PTC |
15*
| Met. PTC | 288 | - | - | Met. PTC |
16
| Met. PTC | 1151 | + | - | Met. PTC |
17
| Met. PTC | 3714 | + | - | Met. PTC |
18
| Met. PTC | 480 | + | - | Met. PTC |
19
| Met. PTC | UND | - | + | Met. MTC |
20
| Met. PTC | UND | - | + | Met. MTC |
21*
| Met. PTC | 62908 | IN | IN | Met. PTC |
22
| Met. PTC | 72.3 | + | - | Met. PTC |
23
| Met. PTC | 10349 | + | - | Met. PTC |
24
| Met. PTC | 384 | ND | ND | Met. PTC |
25*
| Met. PTC | 728 | ND | ND | Met. PTC |
26
| Met. PTC | 53 | + | - | Met. PTC |
27
| Met. PTC | ND | + | - | Met. PTC |
28*
| Met. PTC | ND | + | - | Met. PTC |
29*
| Met. PTC | ND | + | - | Met. PTC |
30
| Epithelial CA | UND | - | - | Met. RFC |
31
| Lymphoma | 10.9 | - | - | Lymphoma |
32
| Met. LC | UND | - | - | Met. LC |
33
| Met. PTC | 3361 | + | - | Met. PTC |
34*
| Benign | 4395 | - | - | Met. PTC |
35*
| Met. PTC | 4388 | + | - | Met. PTC |
Ultrasonography, fine-needle aspiration biopsy (FNAB) and fine-needle washout
Cytological and histological analysis
Tg protein and Tg autoantibody measurements
Extraction and analysis of RNA
Statistical analysis
Results
FNAB cytology (FNAB-C) versus histological diagnosis
Test | Sensitivity | Specificity | PPV | NPV | Accuracy |
---|---|---|---|---|---|
FNAB-C | 84.4 (27/32) [67.2-94.7] | N.D. (0/0) [N.D.] | 100 (27/27) [87.2-100] | N.D. (0/5) [0-52.2] | 84.4 (27/32) [67.2-94.7] |
FNAB-Tgp | 92.3 (24/26) [74.9-99.1] | 83.3 (5/6) [35.9-99.6] | 96.0 (24/25) [79.7-99.9] | 71.4 (5/7) [29.0-96.3] | 90.6 (29/32) [77.7-103.5] |
FNAB-Tgm | 87.5 (21/24) [67.6-97.3] | 100 (6/6) [54.1-100] | 100 (21/21) [83.9-100] | 66.7 (6/9) [29.9-92.5] | 90.0 (27/30) [76.3-103.7] |
FNAB-CTm | 100 (3/3) [29.2-100] | 100 (27/27) [87.2-100] | 100 (3/3) [29.2-100] | 100 (27/27) [87.2-100] | 100 (30/30) [100-100] |
FNAB Tg protein (FNAB-Tgp) versus histological diagnosis
FNAB Tg (FNAB-Tgm) and CT (FNAB-CTm) mRNA versus histological diagnosis
Comparison of the different tests in the diagnosis of suspicious CLN
Test | Sensitivity | Specificity | PPV | NPV | Accuracy |
---|---|---|---|---|---|
PTC + ATC CLN (n = 29)
| |||||
FNAB-C | 88.5 (23/26) [69.9-97.6] | N.D. (0/0) [N.D.] | 100 (23/23) [85.2-100] | N.D. (0/3) [0-70.8] | 88.5 (23/26) [69.9-97.6] |
FNAB-Tgp | 92.3 (24/26) [74.9-99.1] | N.D. (0/0) [N.D.] | 100 (24/24) [85.8-100] | N.D. (0/2) [0-84.2] | 92.3 (24/26) [74.9-99.1] |
FNAB-Tgm | 87.5 (21/24) [88.1-100] | N.D. (0/0) [N.D.] | 100 (21/21) [84.0-100] | N.D. (0/3) [0-70.8] | 87.5 (21/24) [88.1-100] |
FNAB-Tgp + -Tgm | 100 (29/29) [88.1-100] | N.D. (0/0) [N.D.] | 100 (29/29) [88.1-100] | N.D. (0/0) [N.D.] | 100 (29/29) [88.1-100] |
FNAB-C + -Tgp | 96.6 (28/29) [82.2-99.9] | N.D. (0/0) [N.D.] | 100 (28/28) [87.7-100] | N.D. (0/1) [0-97.5] | 96.6 (28/29) [82.2-99.9] |
FNAB-C + -Tgm | 92.9 (26/28) [76.5-99.1] | N.D. (0/0) [N.D.] | 100 (26/26) [86.8-100] | N.D. (0/2) [0-84.2] | 92.9 (26/28) [76.5-99.1] |
FNAB-C + -Tgp + -Tgm | 100 (29/29) [88.1-100] | N.D. (0/0) [N.D.] | 100 (29/29) [88.1-100] | N.D. (0/0) [N.D.] | 100 (29/29) [88.1-100] |
Only PTC CLN (n = 26)
| |||||
FNAB-C | 95.7 (22/23) [78.1-99.9] | N.D. (0/0) [N.D.] | 100 (22/22) [84.6-100] | N.D. (0/1) [0-97.5] | 95.7 (22/23) [78.1-99.9] |
FNAB-Tgp | 100 (23/23) [85.2-100] | N.D. (0/0) [N.D.] | 100 (23/23) [85.2-100] | N.D. (0/0) [N.D.] | 100 (23/23) [85.2-100] |
FNAB-Tgm | 90.5 (19/21) [69.6-98.8] | N.D. (0/0) [N.D.] | 100 (19/19) [82.4-100] | N.D. (0/2) [0-84.2] | 90.5 (19/21) [69.6-98.8] |