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Breast Cancer Research
Erschienen in: Breast Cancer Research 2/2000

01.04.2000 | Commentary

Founder populations and their uses for breast cancer genetics

verfasst von: Susan L Neuhausen

Erschienen in: Breast Cancer Research | Ausgabe 2/2000

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Abstract

Numerous founder mutations have been reported in BRCA1 and BRCA2. For genetic screening of a population with a founder mutation, testing can be targeted to the mutation, allowing for a more rapid and less expensive test. In addition, more precise estimates of the prior probability of carrying a mutation and of the likelihood of a mutation carrier developing cancer should be possible. For a given founder mutation a large number of carriers are available, so that focused scientific studies of penetrance, expression, and genetic and environmental modifiers of risk can be performed. Finally, founder populations may be a powerful resource to localize additional breast cancer susceptibility loci, because of the reduction in locus heterogeneity.
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Metadaten
Titel
Founder populations and their uses for breast cancer genetics
verfasst von
Susan L Neuhausen
Publikationsdatum
01.04.2000
Verlag
BioMed Central
Erschienen in
Breast Cancer Research / Ausgabe 2/2000
Elektronische ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr36

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