Introduction
Methods
Results
RSV and the cardiovascular system
Central nervous system manifestations of RSV
Central apnoeas
Status | Duration (s) | ||
---|---|---|---|
First apnoea | Total apnoea | Recovery time | |
RSV positive | 5.0 ± 0.7a | 10.9 ± 1.8a,b | 38.0 ± 6.0a |
RSV negative | 3.1 ± 0.5 | 5.3 ± 1.0 | 21.0 ± 0.9 |
Controls | 2.5 ± 0.4 | 3.4 ± 1.1 | 19.0 ± 5.0 |
Seizures
Other neurological manifestations
Endocrine effects of RSV bronchiolitis
Antidiuretic hormone
Stress hormone responses
Respiratory syncytial virus-associated hepatitis
Other extrapulmonary manifestations of RSV bronchiolitis
Supportive management of extrapulmonary manifestations of respiratory syncytial virus infection
Discussion
RSV and the cardiovascular system
RSV and the central nervous system
RSV and the endocrine system
RSV and the liver
Agenda for future research
Conclusion
Organs affected | Complication | References |
---|---|---|
Brain | Apnoeas; status epilepticus | [19,20] |
Heart | Ventricular tachycardia; ventricular fibrillation; cardiogenic shock; complete heart block; pericardial tamponade | [7,10,12] |
Brain, liver and kidney | Reye's syndrome | [38] |
Key messages
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Extrapulmonary manifestations are common in children with severe RSV infection.
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Life-threatening extrapulmonary manifestations of RSV infection include central apnoeas, status epilepticus, ventricular tachycardias and fibrillation, heart block and pericardial tamponade and can be detected by adequate monitoring.
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RSV-associated hyponatraemia is common, can cause seizures and needs to be treated by adequate fluid management.