Background
Methods
Part I: Deriving the kinetic parameters of the compartmental model
Part II: Prospective testing of the compartmental model
Results
Part I
Halothane |
---|
V1 = 5.65 + 0.020(WT-70) + 0.68(CO-5) |
V2 = 8.35 + 0.15(WT-70) - 0.49(CO-5) |
V3 = 134.09 + 1.91(WT-70) |
CL1 = 1.23 + 0.050(CO-5) |
CL2 = 2.57 + 0.010(WT-70) + 0.47(CO-5) |
CL3 = 0.87 + 0.17(CO-5) |
Isoflurane
|
V1 = 4.21 + 0.020(WT-70) + 0.39(CO-5) |
V2 = 3.16 + 0.065(WT-70) - 0.31(CO-5) |
V3 = 61.40 + 0.87(WT-70) |
CL1 = 1.12 + 0.024(CO-5) |
CL2 = 1.05 + 0.0037(WT-70) + 0.17(CO-5) |
CL3 = 0.46 + 0.092(CO-5) |
Sevoflurane
|
V1 = 3.33 + 0.018(WT-70) + 0.21(CO-5) |
V2 = 1.51 + 0.033(WT-70) - 0.18(CO-5) |
V3 = 33.69 + 0.47(WT-70) |
CL1 = 1.05 + 0.011(CO-5) |
CL2 = 0.37 + 0.0034(WT-70) + 0.053(CO-5) |
CL3 = 0.23 + 0.046(CO-5) |
Desflurane
|
V1 = 2.94 + 0.017(WT-70) + 0.14(CO-5) |
V2 = 1.56 + 0.030(WT-70) - 0.14(CO-5) |
V3 = 14.08 + 0.19(WT-70) |
CL1 = 1.03 + 0.0066(CO-5) |
CL2 = 0.25 + 0.0022(WT-70) + 0.036(CO-5) |
CL3 = 0.14 + 0.029(CO-5) |
Model derivation | Prospective testing | |||
---|---|---|---|---|
MDPE | MDAPE | MDPE | MDAPE | |
Halothane | 0.00 | 0.18 | 0.31 | 0.38 |
Isoflurane | 0.00 | 0.29 | 0.38 | 0.52 |
Sevoflurane | 0.00 | 0.63 | 0.27 | 0.73 |
Desflurane | 0.00 | 0.74 | 0.51 | 1.51 |