Background
Methods
Data collection
Preprocessing
Patient's attributes
Attributes | |||
---|---|---|---|
Demographics
| - Age | - Gender | - Ethnicity |
- Weight | |||
Medical Conditions
| - Drug allergy | - Cancer type | - Cancer malignancy |
- Comorbidities | - Symptoms of the ADRs | - Hospitalization for prior | |
- ADRs affected organ systems | - Onset of ADRs | ADRs | |
Medications
| - Number of cycles | - Chemotherapeutic drug | - Chemotherapeutic drug class |
- Number of doses | - Concurrent medications | ||
- Dose reduction on rechallenge | - Rechallenge on same day | ||
Laboratory parameters
| - White blood cell | - Red blood cell | - Eosinophil |
- Neutrophil | - Platelet | - Monocyte | |
- Lymphocyte | - Serum creatinine | - Alkaline Phosphatase | |
- Alanine aminotransferase | - Aspartate aminotransferase | - Basophil | |
- Albumin |
Genetic Algorithm Attribute Selection
Naïve Bayes
Performance Evaluation
Results
Clinical Predictors
Numerical attributes | Negative rechallenge (Mean +/- SD) | Positive rechallenge (Mean +/- SD) |
---|---|---|
Age | 47.7 +/- 14.9 | 55.4 +/- 14.2 |
Albumin level | 35.7 +/- 4.6 | 30.9 +/- 5.6 |
RBC level | 4.06 +/- 0.58 | 3.69 +/- 0.81 |
Platelet level | 331.41 +/- 153.62 | 324.39 +/- 150.86 |
Categorical and binominal attributes
|
Negative rechallenge (proportion)
|
Positive rechallenge (proportion)
|
Chemotherapeutic drug
| ||
Oxaliplatin | 0.294 | 0.278 |
Carboplatin | 0.059 | 0.278 |
Bleomycin | 0.059 | 0.000 |
Rituximab | 0.235 | 0.000 |
Paclitaxel | 0.118 | 0.167 |
Docetaxel | 0.059 | 0.111 |
Trastuzumab | 0.118 | 0.056 |
Cetuximab | 0.000 | 0.056 |
Gemcitabine | 0.059 | 0.056 |
Laboratory parameters
| ||
Abnormal WBC level* | 0.118 | 0.444 |
Abnormal ALT level* | 0.118 | 0.278 |
Abnormal AP level* | 0.176 | 0.556 |