Helicopter emergency medical services with a physician (HEMS) has been provided in Japan since 2001. However, HEMS and its possible effect on outcomes for severe trauma patients have still been debated as helicopter services require expensive and limited resources. Our aim was to analyze the association between the use of helicopters with a physician versus ground services and survival among adults with serious traumatic injuries.
Methods
This multicenter prospective observational study involved 24,293 patients. All patients were older than 15 years of age, had sustained blunt or penetrating trauma and had an Injury Severity Score (ISS) higher than 15. All of the patient data were recorded between 2004 and 2011 in the Japan Trauma Data Bank, which includes data from 114 major emergency hospitals in Japan. The primary outcome was survival to discharge from hospitals. The intervention was either transport by helicopter with a physician or ground emergency services.
Results
A total of 2,090 patients in the sample were transported by helicopter, and 22,203 were transported by ground. Overall, 546 patients (26.1%) transported by helicopter died compared to 5,765 patients (26.0%) transported by ground emergency services. Patients transported by helicopter had higher ISSs than those transported by ground. In multivariable logistic regression, helicopter transport had an odds ratio (OR) for survival to discharge of 1.277 (95% confidence interval (CI), 1.049 to 1.556) after adjusting for age, sex, mechanism of injury, type of trauma, initial vital signs (including systolic blood pressure, heart rate and respiratory rate), ISS and prehospital treatment (including intubation, airway protection maneuver and intravenous fluid). In the propensity score–matched cohort, helicopter transport was associated with improved odds of survival compared to ground transport (OR, 1.446; 95% CI, 1.220 to 1.714). In conditional logistic regression, after adjusting for prehospital treatment (including intubation, airway protection maneuver and intravenous fluid), similar positive associations were observed (OR, 1.230; 95% CI, 1.017 to 1.488).
Conclusions
Among patients with major trauma in Japan, transport by helicopter with a physician may be associated with improved survival to hospital discharge compared to ground emergency services after controlling for multiple known confounders.
The online version of this article (doi:10.1186/cc13981) contains supplementary material, which is available to authorized users.
Competing interests
The authors declare that they have no competing interests.
Authors’ contributions
DS contributed to the acquisition of data. All of the authors jointly conceived of and designed this study. TA conducted data cleaning. TA and OT analyzed the data. All of the authors interpreted the data. TA drafted the manuscript. All of the authors reviewed and discussed the manuscript. TA, DS and YT revised the manuscript for important intellectual content. All of the authors read and approved the final manuscript.
Abkürzungen
ED
Emergency department
GEMS
Ground emergency medical services
HEMS
Helicopter emergency medical services
HR
Heart rate
ISS
Injury Severity Score
JTDB
Japan Trauma Data Bank
RR
Respiratory rate
SBP
Systolic blood pressure.
Introduction
Helicopters have been used to transport trauma patients for the past the 40 years all over the world [1]. Physician-staffed helicopter emergency medical services (HEMS) started in Japan in 2001. HEMS and their possible effect on outcomes for severe trauma patients have been debated. Researchers in the United States [2] and Germany [1] have shown the benefits of HEMS. The results of other studies show no significant benefits [3, 4]. Actually, helicopter use seems to provide benefits for trauma patients. It can reduce rescue time and enlarge the catchment area. However, the utility of HEMS depends on time and weather. Also, HEMS cost much more than ground emergency medical services (GEMS). Thus, clear evidence of their effectiveness compared with GEMS is worth seeking because HEMS require limited and expensive resources. Also, knowledge about the effectiveness of HEMS in Japan is important because it is a mountainous island country smaller than the United States. Thus, our purpose in the present study was to analyze and validate the association between the use of HEMS versus GEMS and survival among adults with serious traumatic injuries.
Methods
Ethics statement
We received permission to use data from the Japan Trauma Data Bank (JTDB). The study protocol was reviewed and approved by the ethics committee of Mito Kyodo General Hospital, University of Tsukuba Hospital Mito Medical Center. The ethics committee at our institution does not require consent from patients for observational studies using anonymous data such as those used in this study.
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Study design and data collection
This multicenter, prospective, observational study was devoted to analysis of the association between the use of HEMS versus GEMS and survival among adults with serious traumatic injuries. The data used in this study were derived from the JTDB, which was established in 2003 with the Japanese Association for the Surgery of Trauma (Trauma Registry Committee) and the Japanese Association for Acute Medicine (Committee for Clinical Care Evaluation) as the main parties. The aim of establishing the JTDB was to collect and analyze trauma patient data in Japan (patient and injury characteristics, information from emergency services, vital signs before reaching the hospital and at the first medical examination, inspections and treatments, diagnosis and Injury Severity Score (ISS), disposition after being in the ED or the operating room and information upon discharge from the hospital). The severity of anatomic injuries was evaluated using the ISS. Probability of survival was also calculated on the basis of the Trauma Score and Injury Severity Score [5].
Selection of participants
A total of 94,136 patients were enrolled in the JTDB from 2004 to 2011. Our study included adults older than 15 years of age. The ISS was used to quantify the severity of trauma. An ISS higher than 15 was used as the criterion for inclusion because this has been shown to be associated with a greater need for specialized trauma care [2]. Patients who received other forms of transportation to trauma centers, such as private conveyance or other purposes of transfer to hospitals, were also excluded. Patients with other trauma mechanisms, such as burns, were excluded. Patients who were dead on arrival to the emergency department (ED) were excluded. The analysis was restricted to records with complete information regarding transport and disposition information. Thus, 24,293 patients met our study criteria (Figure 1).
Figure 1
Study flow diagram. Stratification and selection of patient data retrieved from the Japan Trauma Data Bank (JTDB) covering the period from 2004 to 2011.
×
Statistical analysis
Data included in the analysis
The primary intervention was transport by either HEMS or GEMS. The dispatch criteria for HEMS in Japan included shock, long-distance transportation of critical patients, swift transportation due to requirement of special care, such as for burns, polytrauma, amputated extremity or need for emergency care by a physician at the scene. However, the number of HEMS did not cover all such patients. Thus, it depended on the decisions of the operators. The HEMS team was staffed by a physician and a nurse. The GEMS team was staffed by an emergency medical technician and a firefighter. The primary outcome of interest was survival to discharge from the hospital. The secondary outcome of interest was survival to discharge from the ED. These outcomes were evaluated with three analytical models: an unconditional (standard) logistic regression model, a logistic regression model incorporating the results of propensity score matching and a conditional logistic regression model.
Covariates included demographic, physiologic and hospital data. Demographics included information on age and sex. Referring to the previous report [2], covariates were carefully selected on the basis of the assumption that none were affected directly by the intervention. Other variables selected a priori were planned for inclusion in the final statistical models. These variables included the type of trauma (blunt versus penetrating), vital signs at the scene (systolic blood pressure (SBP), respiratory rate (RR), heart rate (HR)) and the locally calculated ISS. ISS and sex were also found to be statistically significant covariates in a previous study in which the investigators compared urban and rural helicopter transport of patients with blunt trauma injuries [6]. The final models included the following independent variables: age; sex; initial vital signs, including SBP, RR and HR; mechanism of injury; type of trauma; transport mode; ISS; and prehospital treatment, including intubation, airway protection maneuver and intravenous fluid. The two-sided significance level for all tests was P < 0.05. All analyses were performed using SPSS software, version 21.0 (IBM, Armonk, NY, USA).
Propensity score
The use of helicopter or ground transport was not randomly assigned, and thus, as the described in the previous report [2], formal causal inference is not credible. Therefore, we used a propensity score approach to condition potential selection bias and confounding. The propensity score model was estimated using a logistic regression model to adjust for the patient characteristics chosen in Table 1. We carefully chose these variables. The variables were significant variables between the two groups. Also, we chose these variables because they had fewer missing values. We referred to prognostically significant variables in the previous study [2]. Age, sex, mechanism of injury, type of trauma, initial vital signs (SBP, HR, RR) and ISS were chosen as the covariates used to estimate the propensity score. This propensity score represents the probability that a patient with severe trauma would be chosen for transport by helicopter or ground. Next, we chose one-to-one matching, which is the most common procedure. One patient transported by helicopter was matched to one patient transported by ground using nearest-neighbor matching without replacement. Propensity scores were matched using a caliper width of 0.25 (standard deviation of the logit). Also, we used a structured iterative approach to refine this logistic regression model to achieve balance of covariates within the matched pairs. We used the standardized difference to measure covariate balance, whereby an absolute standardized difference above 20% represents meaningful imbalance. Paired comparisons were performed using conditional logistic regression analysis because propensity-matched models still have imbalance. For conditional logistic regression analysis, we adjusted prehospital treatment, including intubation, airway protection maneuver and intravenous fluid, because there was significant imbalance between the two groups.
Table 1
Characteristics of patients transported by emergency medical servicesa
Patients by transportation method, n(%)
All patients
Helicopter
Ground
Characteristics
(N = 24,293)
(N = 2,090)
(N = 22,203)
n (%)
Sex
Men
17,265 (71.1)
1,571 (75.2)
15,694 (70.7)
Women
7,023 (28.9)
519 (24.8)
6,504 (29.3)
Age, yr
15 to 55
11,749 (48.4)
884 (42.3)
10,865 (48.9)
56 to 65
4,279 (17.6)
419 (20.0)
3,860 917.4)
>65
8,265 (34.0)
787 (37.7)
7,478 (33.7)
Injury type
Blunt
23,680 (97.5)
2,062 (98.7)
21,618 (97.4)
Penetrating
613 (2.5)
585 (2.6)
28 (1.3)
Cause of injury
Motor vehicle crash
12,638 (53.9)
1,087 (53.2)
11,551 (54.0)
Falls
8,749 (37.3)
675 (33.0)
8,074 (37.7)
Other reason
2,059 (8.8)
283 (13.8)
1,776 (8.3)
Injury severity score
15 to 24
11,747 (52.9)
892 (47.3)
10,855 (53.4)
25 to 34
8,184 (36.8)
738 (39.1)
7,446 (36.6)
35-44
2,279 910.3)
256 (13.6)
2,023 (10.0)
TRISS (P > 0.5)
16,578 (77.7)
1,435 (76.9)
15,143 (77.8)
Alcohol drunk (+)
2,876 (11.8)
53 (4.7)
2,823 (21.6)
Mean (SD)
Prehospital vital signs
Systolic blood pressure, mmHg
132.3 (34.6)
130 (34.8)
132.5 (34.6)
Diastolic blood pressure, mmHg
77.7 (21.3)
76.7 (21.3)
77.8 (21.3)
Respiratory rate, breaths/min
23.0 (7.5)
24.9 (8.5)
22.8 (7.4)
Heart rate, beats/min
87.7 (22.6)
87.7 (23.8)
87.7 (22.5)
Japan coma scale
Grade 0
5,077 (23.5)
408 (26.8)
4,669 (23.3)
Grade 1
6,635 (30.7)
421 (27.6)
6,214 (30.9)
Grade 2
2,591 (12.0)
209 (13.7)
2382 (11.8)
Grade 3
7,333 (33.9)
487 (31.9)
6846 (34.0)
Initial vital signs at ED
Systolic blood pressure, mmHg
118.8 (51.6)
119.1 (44.0)
118.8 (52.2)
Diastolic blood pressure, mmHg
73.0 (27.2)
72.6 (23.8)
73.0 (27.5)
Respiratory rate, breaths/min
20.8 (9.9)
22.2 (9.5)
20.6 (9.9)
Heart rate, beats/min
82.1 (33.2)
85.9 (29.7)
81.8 (33.5)
Glasgow coma scale score
10.9 (4.6)
10.9 (4.7)
10.9 (4.6)
Eye score
2.8 (1.3)
2.8 (1.3)
2.8 (1.3)
Verbal score
3.4 (1.7)
3.7 (1.6)
3.4 (1.7)
Motor score
4.7 (1.9)
4.7 (2.0)
4.7 (1.9)
Japan coma scale
Grade 0
5,191 (26.5)
540 (30.1)
4,651 (26.1)
Grade 1
5,127 (26.1)
407 (22.7)
4,720 (26.5)
Grade 2
2,990 (15.2)
260 (14.5)
2,730 (15.3)
Grade 3
6,304 (32.1)
588 (32.8)
5,716 (32.1)
Body temperature, °C
36.0 (1.1)
36.0 (1.1)
36.0 (1.1)
aED: Emergency department; TRISS: Trauma Score and Injury Severity Score.
Japan coma scale (Grade 0: alert, Grade 1: possible eye-opening, not lucid, Grade 2: possible eye-opening upon stimulation, Grade 3: no eye-opening and coma).
Also, Japan coma scale is categorical data. Thus, its unit is n (%).
Results
There were 24,293 patients in the JTDB who had major trauma, among whom 2,090 were transported by HEMS and 22,203 were transported by GEMS. Patient demographics and characteristics are summarized in Tables 1, 2 and 3. The mean age was 56.2 ± 19.6 in the HEMS group and 53.1 ± 21.1 in the GEMS cohort (P < 0.001). Patients transported by HEMS had higher ISSs (28.4 ± 12.7) than those transported by GEMS (26.8 ± 12.3) (P < 0.001). Among the patients who died, 546 (26.1%) were transported by HEMS and 5,765 patients (26.0%) by GEMS.
Table 2
Characteristics of preexisting medical conditionsa
Characteristics of treatment and outcome among patients transported by emergency medical servicesa
Patients by transportation method, n(%)
All patients, n (%)
Helicopter
Ground
(N = 24,293)
(N = 2,090)
(N = 22,203)
Prehospital treatment
O2
17,110 (70.4)
1,475 (70.6)
15,635 (70.4)
Cervical collar
14,611 (60.1)
1,259 (60.2)
13,352 (60.1)
Backboard
14,181 (58.4)
1,349 (64.5)
12,832 (57.8)
Shock pants
21 (0.1)
2 (0.1)
19 (0.1)
Splint
309 (1.3)
22 (1.1)
287 (1.3)
Intubation
1,840 (7.6)
121 (5.8)
1,719 (7.7)
Nasal airway tube
240 (1.0)
10 (0.5)
230 (1.0)
Airway protection maneuver
2,023 (8.3)
233 (11.1)
1,790 (8.1)
Intravenous fluid
963 (4.0)
395 (18.9)
568 (2.6)
FAST at ED
Positive
2,919 (12.7)
309 (15.4)
2,610 (12.4)
Negative
16,598 (71.9)
1,559 (77.8)
15,039 (71.4)
Not used
3,557 (15.4)
136 (6.8)
3,421 (16.2)
CT
Head
20,473 (84.3)
1,708 (81.7)
18,765 (84.5)
Neck
12,246 (50.4)
1,138 (54.4)
11,108 (50.0)
Spine
4,845 (19.9)
485 (23.2)
4,360 (19.6)
Chest
16,155 (66.5)
1,577 (75.5)
14,578 (65.7)
Abdomen
15,376 (63.3)
1,502 (71.9)
13,874 (62.5)
Pelvis
12,424 (51.1)
1,006 (48.1)
11,418 (51.4)
Others
899 (3.7)
72 (3.4)
827 (3.7)
Angiography
Head
298 (1.2)
27 (1.3)
271 (1.2)
Neck
131 (0.5)
12 (0.6)
119 (0.5)
Spine
46 (0.2)
4 (0.2)
42 (0.2)
Chest
335 (1.4)
36 (1.7)
299 (1.3)
Abdomen
1,190 (4.9)
119 (5.7)
1,071 (4.8)
Pelvis
1,215 (5.0)
143 (6.8)
1,072 (4.8)
Others
81 (0.3)
12 (0.6)
69 (0.3)
Blood transfusion (+)
6,611 (28.0)
782 (38.2)
5,829 (27.0)
Operation
Craniotomy
2,055 (8.5)
142 (6.8)
1,913 (8.6)
Craterization
716 (2.9)
36 (1.7)
680 (3.1)
Throracotomy
947 (3.9)
130 (6.2)
817 (3.7)
Celiotomy
1,427 (5.9)
177 (8.5)
1,250 (5.6)
Bone fixation
3,606 (14.8)
432 (20.7)
3,174 (14.3)
Angiostomy
68 (0.3)
6 (0.3)
62 (0.3)
TAE
1,237 (5.1)
127 (6.1)
1,110 (5.0)
Endoscopic surgery
23 (0.1)
3 (0.1)
20 (0.1)
Anastomosis
9 (0.0)
1 (0.0)
8 (0.0)
Others
959 (3.9)
93 (4.4)
866 (3.9)
Disposition at ED
Died
2,004 (8.2)
1,877 (8.5)
127 (6.1)
ICU
18,439 (75.9)
1,634 (78.2)
16,805 (75.7)
Ward
3,197 (13.2)
184 (8.8)
3,013 (13.6)
Others
452 (1.9)
139 (6.7)
313 (1.4)
Disposition at discharge
Died
6,311 (26.0)
546 (26.1)
5,765 (26.0)
Hospital transfer
10,172 (41.9)
1,063 (50.9)
9,109 (41.0)
Home
7,810 (32.1)
481 (23.0)
7,329 (33.0)
aCT: Computed tomography; ED: Emergency department, FAST: Focused assessment with sonography in trauma; TAE: Transcatheter arterial embolization.
The results of the logistic regression models are listed in Table 4. Crude survival did not differ significantly between the HEMS and GEMS cohorts. However, HEMS showed a significantly greater odds ratio (OR) of survival in the standard logistic regression models (OR, 1.277 (95% confidence interval (CI), 1.049 to 1.556)).
Table 4
Association between transportation method and survival outcomea
Survival OR (95% CI)
Analysis
At discharge
At ED
Crude (N = 24,293)
0.992 (0.895 to 1.098)
1.437 (1.193 to 1.730)
Unconditional logistic regression
Standard (n = 15,382)
1.277 (1.049 to 1.556)
1.141 (0.729 to 1.785)
After propensity score matchingb (n = 2,510)
1.446 (1.220 to 1.714)
2.367 (1.822 to 3.075)
Conditional logistic regression (n = 2,510)
1.230 (1.017 to 1.488)
1.703 (1.255 to 2.311)
aCI: Confidence interval; ED: Emergency department; OR: Odds ratio. bThe covariates used to estimate the propensity score were age, sex, mechanism of injury, type of trauma, initial vital signs (systolic blood pressure, heart rate, risk ratio) and Injury Severity Score.
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In addition, we analyzed the relationship between transport and survival in propensity-matched patients. To calculate the propensity score, a multivariable logistic regression model was fitted. This model yielded an area under the curve of 0.641 (95% CI, 0.625 to 0.658), which indicated a relatively good ability to differentiate those transported by HEMS from those by GEMS. To assess the robustness of the results, we performed a series of sensitivity analyses (Table 5). With respect to every predictor variable, significant differences in prehospital treatment were detected between patients transported by HEMS compared to GEMS. Thus, we used conditional logistic regression for prehospital treatment to be well-matched. The survival rates of patients transported by HEMS were significantly greater than those transported by GEMS (OR, 1.446 (95% CI, 1.220 to 1.714) after propensity score matching; OR, 1.230 (95% CI, 1.017 to 1.488) in conditional logistic regression) (Table 4).
Table 5
Baseline characteristics patients with severe trauma in propensity-matched patients
Patients by transportation method, n(%)
Helicopter
Ground
(N = 1,255)
(N = 1,255)
SDa(%)
Males
949 (75.6)
918 (73.3)
5.3%
Age, yr
55.2 (19.5)
54.4 (20.8)
4.0%
Injury type
Blunt
1,239 (98.7)
1,240 (98.8)
0.9%
Penetrating
16 (1.3)
15 (1.2)
Cause of injury
Motor vehicle crashes
656 (54.2)
613 (54.1)
9.8%
Falls
415 (34.3)
450 (39.7)
11.2%
Other reasons
139 (11.5)
70 (6.2)
18.7%
Injury severity score
27.5 (12.6)
28.3 (14.4)
5.9%
Prehospital vital signs
Systolic blood pressure, mmHg
131.6 (86.9)
133.8 (36.2)
3.3%
Respiratory rate, breaths/min
23.5 (5.5)
22.8 (5.5)
12.7%
Heart rate, beats/min
86.9 (23.9)
87.0 (20.9)
0.4%
Prehospital treatment
Intubation
70 (5.6)
164 (13.1)
26.0%
Airway protection maneuver
124 (9.9)
133 (10.6)
1.6%
Intravenous fluid
217 (17.3)
38 (3.0)
48.7%
aSD: Standardized difference.
Discussion
Although the impact of HEMS and GEMS is still debated, our findings support the results of recent studies on HEMS with advanced statistics [1, 2, 7‐10]. Actually, the ORs reported in those studies were very similar (Table 6). Our summary evaluation of these studies is that HEMS has a survival benefit compared to GEMS, although HEMS patients had more serious medical conditions. We added robust results in this area because we used rigorous methods after controlling for the same multiple known confounders that Galvagno et al. did [2]. However, because a helicopter is not a treatment, but instead just a vehicle, its effects include heterogeneity. It could be a surrogate marker. Also important is carefully consideration of which elements of HEMS may be beneficial for patients [11]. Other factors to consider are speed, distance, time, trauma center access, crew expertise, level of primary hospital treatment, duration of flight and severity of patient condition.
Table 6
Summary of recent studies using multivariate logistic regression to compare helicopter versus ground emergency medical servicesa
aCI: Confidence interval; GEMS: Ground emergency medical services; HEMS: Helicopter emergency medical services; OR: Odds ratio. Modification of Table 1 in Galvagno et al. [11].
Compared to GEMS, HEMS can transport patients with serious injuries greater distances significantly faster. Time to definitive trauma care (particularly hemostasis requiring surgery) is known to strongly influence outcome [12]. In a previous study, researchers suggested a road distance more than 10 miles or an expected transport time more than 45 minutes by GEMS is the minimum at which helicopter transport could be faster [13]. We do not have distance and time information in this database. However, we know the duration of transportation in many cases was less than these suggested thresholds, because there are many emergency centers in small areas in Japan. So, HEMS could have other merits besides access, including speed and distance.
Crew expertise is likely to be an important contributing factor for improved survival in HEMS patients. HEMS in Germany and Europe are exclusively physician-staffed, as in Japan. This could be a potential benefit. In the present study, prehospital treatment, especially intravenous fluid, was statistically significantly different because GEMS in Japan do not allow prehospital treatment, except for cardiopulmonary arrest patients. Being staffed by well-trained physicians must be a beneficial element. Being well-trained could be more important than physician-staffed, however, because, for example, many HEMS are not physician-staffed in the United States.
Variation in hospital capability has a potential impact on outcome. Biewener et al. concluded in their study that the level of primary hospital treatment, but not the transportation mode, influenced patients’ survival [3]. However, Andruszkow et al. reported that HEMS seemed to influence survival independently of level I treatment [1]. We did not control for the level of institutions; however, institutions that join JTDB meet a certain standard of trauma care, because almost all are emergency centers certified by the Japanese Ministry of Health, Labour and Welfare.
Another consideration is that HEMS operate only during daytime in Japan. That factor could affect outcome data, because hospital functions are more sophisticated in daytime than at night. However, HEMS also operate during the night in other countries. Moreover, with regard to the severity of patient condition, the authors of a previous report stated that patients transported by urban GEMS arrive at the hospital with more severe injuries and have higher in-hospital death rates than patients from rural areas who survive and are transported by HEMS [14]. However, we controlled for the severity of patients’ injuries by using the ISS as the researchers in a previous study did [2].
Our study has several limitations. First, the absence of distance and time information is one. Second, we did not control for staffing in each vehicle. Indeed, this difference is one of the most important confounders in this study. However, it is difficult to avoid this factor in the Japanese emergency system. An important factor related to staffing is prehospital treatment, and we controlled for intubation, airway protection maneuver and intravenous fluid. Third, we could not analyze the cost of each vehicle, because we did not obtain cost data. Nonetheless, public broadcasters in Japan indicate that emergency helicopters force Japanese communities to shoulder a huge financial burden. Fourth, we have missing data, which might have influenced the results. Although Moore et al. recommended using multiple imputation as a more accurate data model than the one we used [15], we chose the simple approach of eliminating all patients with missing data on important covariates because of the size of our data set. Actually, our data set had much less missing data than Galvagno et al.’s [2]. Fifth, there could be unknown bias, although we controlled for known bias by using a propensity score. However, our method is relatively robust because a randomized controlled trial comparing HEMS with GEMS is not feasible. Moreover, we did not evaluate the quality of posttrauma life, because we dealt only with the outcome of survival.
Conclusion
The results of this study demonstrate that transport by helicopter with a physician may be associated with improved survival to hospital discharge compared to ground services, after controlling for multiple known confounders among patients with major trauma in Japan. Probably the combination of elements of HEMS has benefits for patients with trauma, although we could not detect the most likely contributing factor. Additional work is needed to determine whether transport by helicopter or time to high-level care, such as physician staffing, might be the association determinant of trauma survival.
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Key messages
We add robust results to previously published data on the relative benefits of HEMS compared to GEMS based on our rigorous analytical methods after controlling for multiple known confounders.
HEMS demonstrated a survival benefit compared to GEMS, although HEMS patients had more serious medical conditions.
Acknowledgement
We thank all investigators who coordinated or participated in the JTDB. We thank Brian K Purdue for his English-language manuscript revision.
Competing interests
The authors declare that they have no competing interests.
Authors’ contributions
DS contributed to the acquisition of data. All of the authors jointly conceived of and designed this study. TA conducted data cleaning. TA and OT analyzed the data. All of the authors interpreted the data. TA drafted the manuscript. All of the authors reviewed and discussed the manuscript. TA, DS and YT revised the manuscript for important intellectual content. All of the authors read and approved the final manuscript.
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Schmerzen im Unterbauch, aber sonst nicht viel, was auf eine Appendizitis hindeutete: Ein junger Mann hatte Glück, dass trotzdem eine Laparoskopie mit Appendektomie durchgeführt und der Wurmfortsatz histologisch untersucht wurde.
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