The online version of this article (doi:10.1186/1475-2840-11-11) contains supplementary material, which is available to authorized users.
The authors declare that they have no competing interests.
Conceived and designed the experiments: ZY, RH Performed the experiments: YH, ZY, QL Analyzed the data: ZY Contributed reagents/materials/analysis tools: JW, XT, LC, MH, XW, BL, ZZ, WZ, SQ. Wrote the paper: YH All authors read and approved the final manuscript.
Lipocalin-2 is a novel adipokine with connection to insulin resistance. In this study, we aimed to investigate the association of serum lipocalin-2 with glucose metabolism and other metabolic phenotype in a large-scale Chinese population.
We evaluated serum lipocalin-2 in a cross-sectional sample of 2519 Chinese aged from 50 to 82 year in a Shanghai downtown district by ELISA. Glucose, insulin, lipid profile, inflammatory markers, and adipokines were also measured.
Serum lipocalin-2 was significantly higher in subjects with isolated impaired fasting glucose, isolated impaired glucose tolerance, combined impaired fasting glucose/impaired glucose tolerance and newly-diagnosed type 2 diabetes than in those with normal glucose regulation. Lipocalin-2 elevation was clearly associated with a higher risk for impaired glucose regulation (OR 1.30 for each 10 ng/ml increase in serum lipocalin-2, 95% CI 1.23-1.62, p = 0.009) after adjustment of age, gender, smoking, alcohol drinking, family history of diabetes, serum CRP, serum adiponectin, serum CXCL5, HOMA-IR, BMI, and waist/hip ratio. The OR for participants with impaired glucose regulation and type 2 diabetes was 1.31 (95% CI 1.21-1.69, p < 0.001).
Our findings suggest that elevated serum lipocalin-2 is closely and independently associated with impaired glucose regulation and type 2 diabetes.
Authors’ original file for figure 112933_2011_437_MOESM1_ESM.tiff
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- Lipocalin-2, glucose metabolism and chronic low-grade systemic inflammation in Chinese people
- BioMed Central
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