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Brain Structure and Function

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04.08.2017 | Original Article

Localization of endogenous amyloid-β to the coeruleo-cortical pathway: consequences of noradrenergic depletion

verfasst von: Jennifer A. Ross, Beverly A. S. Reyes, Steven A. Thomas, Elisabeth J. Van Bockstaele

Erschienen in: Brain Structure and Function | Ausgabe 1/2018

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Abstract

The locus coeruleus (LC)–norepinephrine (NE) system is an understudied circuit in the context of Alzheimer’s disease (AD), and is thought to play an important role in neurodegenerative and neuropsychiatric diseases involving catecholamine neurotransmitters. Understanding the expression and distribution of the amyloid beta (Aβ) peptide, a primary component of AD, under basal conditions and under conditions of NE perturbation within the coeruleo-cortical pathway may be important for understanding its putative role in pathological states. Thus, the goal of this study is to define expression levels and the subcellular distribution of endogenous Aβ with respect to noradrenergic profiles in the rodent LC and medial prefrontal cortex (mPFC) and, further, to determine the functional relevance of NE in modulating endogenous Aβ₄₂ levels. We report that endogenous Aβ₄₂ is localized to tyrosine hydroxylase (TH) immunoreactive somatodendritic profiles of the LC and dopamine-β-hydroxylase (DβH) immunoreactive axon terminals of the infralimbic mPFC (ILmPFC). Male and female naïve rats have similar levels of amyloid precursor protein (APP) cleavage products demonstrated by western blot, as well as similar levels of endogenous Aβ₄₂ as determined by enzyme-linked immunosorbent assay. Two models of NE depletion, DSP-4 lesion and DβH knockout (KO) mice, were used to assess the functional relevance of NE on endogenous Aβ₄₂ levels. DSP-4 lesioned rats and DβH-KO mice show significantly lower levels of endogenous Aβ₄₂. Noradrenergic depletion did not change APP-cleavage products resulting from β-secretase processing. Thus, resultant decreases in endogenous Aβ₄₂ may be due to decreased neuronal activity of noradrenergic neurons, or, by decreased stimulation of adrenergic receptors which are known to contribute to Aβ₄₂ production by enhancing γ-secretase processing under normal physiological conditions.

Abramov E, Dolev I, Fogel H, Ciccotosto GD, Ruff E, Slutsky I (2009) Amyloid-beta as a positive endogenous regulator of release probability at hippocampal synapses. Nat Neurosci 12(12):1567–1576CrossRefPubMed

Benarroch EE (2009) The locus ceruleus norepinephrine system: functional organization and potential clinical significance. Neurology 73(20):1699–1704CrossRefPubMed

Berridge CW, Waterhouse BD (2003) The locus coeruleus-noradrenergic system: modulation of behavioral state and state-dependent cognitive processes. Brain Res Brain Res Rev 42(1):33–84CrossRefPubMed

Caporaso GL, Takei K, Gandy SE, Matteoli M, Mundigl O, Greengard P, De Camilli P (1994) Morphologic and biochemical analysis of the intracellular trafficking of the Alzheimer beta/A4 amyloid precursor protein. J Neurosci 14(5 Pt 2):3122–3138PubMed

Chalermpalanupap T, Kinkead B, Hu WT, Kummer MP, Hammerschmidt T, Heneka MT, Weinshenker D, Levey AI (2013) Targeting norepinephrine in mild cognitive impairment and Alzheimer’s disease. Alzheimers Res Ther 5(2):21CrossRefPubMedPubMedCentral

Chen Y, Peng Y, Che P, Gannon M, Liu Y, Li L, Bu G, van Groen T, Jiao K, Wang Q (2014) Alpha(2A) adrenergic receptor promotes amyloidogenesis through disrupting APP-SorLA interaction. Proc Natl Acad Sci USA 111(48):17296–17301CrossRefPubMedPubMedCentral

Cirrito JR, Yamada KA, Finn MB, Sloviter RS, Bales KR, May PC, Schoepp DD, Paul SM, Mennerick S, Holtzman DM (2005) Synaptic activity regulates interstitial fluid amyloid-beta levels in vivo. Neuron 48(6):913–922CrossRefPubMed

Cirrito JR, Kang JE, Lee J, Stewart FR, Verges DK, Silverio LM, Bu G, Mennerick S, Holtzman DM (2008) Endocytosis is required for synaptic activity-dependent release of amyloid-beta in vivo. Neuron 58(1):42–51CrossRefPubMedPubMedCentral

Commons KG, Beck SG, Rudoy C, Van Bockstaele EJ (2001) Anatomical evidence for presynaptic modulation by the delta opioid receptor in the ventrolateral periaqueductal gray of the rat. J Comp Neurol 430(2):200–208CrossRefPubMed

Crestani CC, Alves FH, Gomes FV, Resstel LB, Correa FM, Herman JP (2013) Mechanisms in the bed nucleus of the stria terminalis involved in control of autonomic and neuroendocrine functions: a review. Curr Neuropharmacol 11(2):141–159CrossRefPubMedPubMedCentral

Curtis AL, Lechner SM, Pavcovich LA, Valentino RJ (1997) Activation of the locus coeruleus noradrenergic system by intracoerulear microinfusion of corticotropin-releasing factor: effects on discharge rate, cortical norepinephrine levels and cortical electroencephalographic activity. J Pharmacol Exp Ther 281(1):163–172PubMed

Del Prete D, Lombino F, Liu X, D’Adamio L (2014) APP is cleaved by Bace1 in pre-synaptic vesicles and establishes a pre-synaptic interactome, via its intracellular domain, with molecular complexes that regulate pre-synaptic vesicles functions. PLoS One 9(9):e108576CrossRefPubMedPubMedCentral

Feinstein DL, Heneka MT, Gavrilyuk V, Dello Russo C, Weinberg G, Galea E (2002) Noradrenergic regulation of inflammatory gene expression in brain. Neurochem Int 41(5):357–365CrossRefPubMed

Flavin SA, Winder DG (2013) Noradrenergic control of the bed nucleus of the stria terminalis in stress and reward. Neuropharmacology 70:324–330CrossRefPubMedPubMedCentral

Foote SL, Bloom FE, Aston-Jones G (1983) Nucleus locus ceruleus: new evidence of anatomical and physiological specificity. Physiol Rev 63:844–914CrossRefPubMed

Fritschy JM (2008) Is my antibody-staining specific? How to deal with pitfalls of immunohistochemistry. Eur J Neurosci 28(12):2365–2370CrossRefPubMed

Gray EG (1959) Electron microscopy of synaptic contacts on dendrite spines of the cerebral cortex. Nature 183(4675):1592–1593CrossRefPubMed

Haass C, Schlossmacher MG, Hung AY, Vigo-Pelfrey C, Mellon A, Ostaszewski BL, Lieberburg I, Koo EH, Schenk D, Teplow DB et al (1992) Amyloid beta-peptide is produced by cultured cells during normal metabolism. Nature 359(6393):322–325CrossRefPubMed

Hartman BK, Zide D, Udenfriend S (1972) The use of dopamine-hydroxylase as a marker for the central noradrenergic nervous system in rat brain. Proc Natl Acad Sci USA 69(9):2722–2726CrossRefPubMedPubMedCentral

Heneka MT, Galea E, Gavriluyk V, Dumitrescu-Ozimek L, Daeschner J, O’Banion MK, Weinberg G, Klockgether T, Feinstein DL (2002) Noradrenergic depletion potentiates beta-amyloid-induced cortical inflammation: implications for Alzheimer’s disease. J Neurosci 22(7):2434–2442PubMed

Hinojosa AE, Caso JR, Garcia-Bueno B, Leza JC, Madrigal JL (2013) Dual effects of noradrenaline on astroglial production of chemokines and pro-inflammatory mediators. J Neuroinflammation 10:81CrossRefPubMedPubMedCentral

Ikin AF, Annaert WG, Takei K, De Camilli P, Jahn R, Greengard P, Buxbaum JD (1996) Alzheimer amyloid protein precursor is localized in nerve terminal preparations to Rab5-containing vesicular organelles distinct from those implicated in the synaptic vesicle pathway. J Biol Chem 271(50):31783–31786CrossRefPubMed

Jardanhazi-Kurutz D, Kummer MP, Terwel D, Vogel K, Dyrks T, Thiele A, Heneka MT (2010) Induced LC degeneration in APP/PS1 transgenic mice accelerates early cerebral amyloidosis and cognitive deficits. Neurochem Int 57(4):375–382CrossRefPubMed

Ji XH, Cao XH, Zhang CL, Feng ZJ, Zhang XH, Ma L, Li BM (2008) Pre- and postsynaptic beta-adrenergic activation enhances excitatory synaptic transmission in layer V/VI pyramidal neurons of the medial prefrontal cortex of rats. Cereb Cortex 18(7):1506–1520CrossRefPubMed

Kalinin S, Polak PE, Lin SX, Sakharkar AJ, Pandey SC, Feinstein DL (2012) The noradrenaline precursor l-DOPS reduces pathology in a mouse model of Alzheimer’s disease. Neurobiol Aging 33(8):1651–1663CrossRefPubMed

Kinoshita A, Shah T, Tangredi MM, Strickland DK, Hyman BT (2003) The intracellular domain of the low density lipoprotein receptor-related protein modulates transactivation mediated by amyloid precursor protein and Fe65. J Biol Chem 278(42):41182–41188CrossRefPubMed

Koenig T, Prichep L, Dierks T, Hubl D, Wahlund LO, John ER, Jelic V (2005) Decreased EEG synchronization in Alzheimer’s disease and mild cognitive impairment. Neurobiol Aging 26(2):165–171CrossRefPubMed

Kong Y, Ruan L, Qian L, Liu X, Le Y (2010) Norepinephrine promotes microglia to uptake and degrade amyloid beta peptide through upregulation of mouse formyl peptide receptor 2 and induction of insulin-degrading enzyme. J Neurosci 30(35):11848–11857CrossRefPubMed

LaFerla FM, Green KN, Oddo S (2007) Intracellular amyloid-beta in Alzheimer’s disease. Nat Rev Neurosci 8(7):499–509CrossRefPubMed

Lavretsky H, Siddarth P, Kepe V, Ercoli LM, Miller KJ, Burggren AC, Bookheimer SY, Huang SC, Barrio JR, Small GW (2009) Depression and anxiety symptoms are associated with cerebral FDDNP-PET binding in middle-aged and older nondemented adults. Am J Geriatr Psychiatry 17(6):493–502CrossRefPubMedPubMedCentral

Leranth C, Pickel VM (1989) Electron microscopic preembedding double-labeling methods. In: Heimer L, Zaborszky L (eds) Neuroanatomical tracing methods 2. 1st edn. Plenum Press, New York, pp 129–172CrossRef

Levitt M, Spector S, Sjoerdsma A, Udenfriend S (1965) Elucidation of the rate-limiting step in norepinephrine biosynthesis in the perfused guinea-pig heart. J Pharmacol Exp Ther 148:1–8PubMed

Liu Y, Liang X, Ren WW, Li BM (2014) Expression of beta1- and beta2-adrenoceptors in different subtypes of interneurons in the medial prefrontal cortex of mice. Neuroscience 257:149–157CrossRefPubMed

Marien MR, Colpaert FC, Rosenquist AC (2004) Noradrenergic mechanisms in neurodegenerative diseases: a theory. Brain Res Brain Res Rev 45(1):38–78CrossRefPubMed

McCall JG, Al-Hasani R, Siuda ER, Hong DY, Norris AJ, Ford CP, Bruchas MR (2015) CRH engagement of the locus coeruleus noradrenergic system mediates stress-induced anxiety. Neuron 87(3):605–620CrossRefPubMedPubMedCentral

McKeith I, Cummings J (2005) Behavioural changes and psychological symptoms in dementia disorders. Lancet Neurol 4(11):735–742CrossRefPubMed

Mizuguchi M, Ikeda K, Kim SU (1992) Beta-amyloid precursor protein of Alzheimer’s disease in cultured bovine oligodendrocytes. J Neurosci Res 32(1):34–42CrossRefPubMed

Murchison CF, Zhang XY, Zhang WP, Ouyang M, Lee A, Thomas SA (2004) A distinct role for norepinephrine in memory retrieval. Cell 117(1):131–143CrossRefPubMed

Nagatsu T, Levitt M, Udenfriend S (1964) Tyrosine hydroxylase. The initial step in norepinephrine biosynthesis. J Biol Chem 239:2910–2917PubMed

Ni Y, Zhao X, Bao G, Zou L, Teng L, Wang Z, Song M, Xiong J, Bai Y, Pei G (2006) Activation of beta2-adrenergic receptor stimulates gamma-secretase activity and accelerates amyloid plaque formation. Nat Med 12(12):1390–1396CrossRefPubMed

Oropeza VC, Mackie K, Van Bockstaele EJ (2007) Cannabinoid receptors are localized to noradrenergic axon terminals in the rat frontal cortex. Brain Res 1127(1):36–44CrossRefPubMed

Paxinos G, Watson C (1997) The rat brain in stereotaxic coordinates. Academic Press, Cambridge

Peters A, Palay SL (1991) The fine structure of the nervous system: neurons and their supporting cells. Oxford University Pres, Oxford

Pickel VM, Joh TH, Field PM, Becker CG, Reis DJ (1975) Cellular localization of tyrosine hydroxylase by immunohistochemistry. J Histochem Cytochem 23(1):1–12CrossRefPubMed

Pietrzak RH, Lim YY, Neumeister A, Ames D, Ellis KA, Harrington K, Lautenschlager NT, Restrepo C, Martins RN, Masters CL, Villemagne VL, Rowe CC, Maruff PB, Australian Imaging and G. Lifestyle Research (2015) Amyloid-beta, anxiety, and cognitive decline in preclinical Alzheimer disease: a multicenter, prospective cohort study. JAMA Psychiatry 72(3):284–291CrossRefPubMed

Puzzo D, Privitera L, Leznik E, Fa M, Staniszewski A, Palmeri A, Arancio O (2008) Picomolar amyloid-beta positively modulates synaptic plasticity and memory in hippocampus. J Neurosci 28(53):14537–14545CrossRefPubMedPubMedCentral

Ramakers IH, Verhey FR, Scheltens P, Hampel H, Soininen H, Aalten P, Rikkert MO, Verbeek MM, Spiru L, Blennow K, Trojanowski JQ, Shaw LM, Visser PJ (2013) Anxiety is related to Alzheimer cerebrospinal fluid markers in subjects with mild cognitive impairment. Psychol Med 43(5):911–920CrossRefPubMed

Reyes BA et al (2006) Pro-opiomelanocortin colocalizes with corticotropin-releasing factor in axon terminals of the noradrenergic nucleus locus coeruleus. Eur J Neurosci 23(8):2067–2077CrossRefPubMed

Reyes BAS, Johnson AD, Glaser JD, Commons KG, Van Bockstaele EJ (2007) Dynorphin-containing axons directly innervate noradrenergic neurons in the rat nucleus locus coeruleus. Neuroscience 145:1077–1086CrossRefPubMedPubMedCentral

Ridet JL, Rajaofetra N, Teilhac JR, Geffard M, Privat A (1993) Evidence for nonsynaptic serotonergic and noradrenergic innervation of the rat dorsal horn and possible involvement of neuron-glia interactions. Neuroscience 52(1):143–157CrossRefPubMed

Rodrigues DI, Gutierres J, Pliassova A, Oliveira CR, Cunha RA, Agostinho P (2014) Synaptic and sub-synaptic localization of amyloid-beta protein precursor in the rat hippocampus. J Alzheimers Dis 40(4):981–992PubMed

Rogaeva E, Meng Y, Lee JH, Gu Y, Kawarai T, Zou F, Katayama T, Baldwin CT, Cheng R, Hasegawa H, Chen F, Shibata N, Lunetta KL, Pardossi-Piquard R, Bohm C, Wakutani Y, Cupples LA, Cuenco KT, Green RC, Pinessi L, Rainero I, Sorbi S, Bruni A, Duara R, Friedland RP, Inzelberg R, Hampe W, Bujo H, Song YQ, Andersen OM, Willnow TE, Graff-Radford N, Petersen RC, Dickson D, Der SD, Fraser PE, Schmitt-Ulms G, Younkin S, Mayeux R, Farrer LA, St George-Hyslop P (2007) The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease. Nat Genet 39(2):168–177CrossRefPubMedPubMedCentral

Ross SB, Renyl AL (1976) On the long-lasting inhibitory effect of N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP 4) on the active uptake of noradrenaline. J Pharm Pharmacol 28(5):458–459CrossRefPubMed

Ross SB, Johansson JG, Lindborg B, Dahlbom R (1973) Cyclizing compounds. I. Tertiary N-(2-bromobenzyl)-N-haloalkylamines with adrenergic blocking action. Acta Pharm Suec 10(1):29–42PubMed

Ross JA, McGonigle P, Van Bockstaele EJ (2015) Locus coeruleus, norepinephrine and abeta peptides in Alzheimer’s disease. Neurobiol Stress 2:73–84CrossRefPubMedPubMedCentral

Seubert P, Vigo-Pelfrey C, Esch F, Lee M, Dovey H, Davis D, Sinha S, Schlossmacher M, Whaley J, Swindlehurst C et al (1992) Isolation and quantification of soluble Alzheimer’s beta-peptide from biological fluids. Nature 359(6393):325–327CrossRefPubMed

Shoji M, Golde TE, Ghiso J, Cheung TT, Estus S, Shaffer LM, Cai XD, McKay DM, Tintner R, Frangione B et al (1992) Production of the Alzheimer amyloid beta protein by normal proteolytic processing. Science 258(5079):126–129CrossRefPubMed

Strosberg AD (1993) Structure, function, and regulation of adrenergic receptors. Protein Sci 2(8):1198–1209CrossRefPubMedPubMedCentral

Teich AF, Patel M, Arancio O (2013) A reliable way to detect endogenous murine beta-amyloid. PLoS ONE 8(2):e55647CrossRefPubMedPubMedCentral

Thathiah A, De Strooper B (2011) The role of G protein-coupled receptors in the pathology of Alzheimer’s disease. Nat Rev Neurosci 12(2):73–87CrossRefPubMed

Thathiah A, Horre K, Snellinx A, Vandewyer E, Huang Y, Ciesielska M, De Kloe G, Munck S, De Strooper B (2013) beta-arrestin 2 regulates Abeta generation and gamma-secretase activity in Alzheimer’s disease. Nat Med 19(1):43–49CrossRefPubMed

Thomas SA, Matsumoto AM, Palmiter RD (1995) Noradrenaline is essential for mouse fetal development. Nature 374(6523):643–646CrossRefPubMed

Thomas SA, Marck BT, Palmiter RD, Matsumoto AM (1998) Restoration of norepinephrine and reversal of phenotypes in mice lacking dopamine beta-hydroxylase. J Neurochem 70(6):2468–2476CrossRefPubMed

Tomimoto H, Akiguchi I, Wakita H, Nakamura S, Kimura J (1995) Ultrastructural localization of amyloid protein precursor in the normal and postischemic gerbil brain. Brain Res 672(1–2):187–195CrossRefPubMed

Toneff T, Funkelstein L, Mosier C, Abagyan A, Ziegler M, Hook V (2013) Beta-amyloid peptides undergo regulated co-secretion with neuropeptide and catecholamine neurotransmitters. Peptides 46:126–135CrossRefPubMed

Traub RD, Cunningham MO, Gloveli T, LeBeau FE, Bibbig A, Buhl EH, Whittington MA (2003) GABA-enhanced collective behavior in neuronal axons underlies persistent gamma-frequency oscillations. Proc Natl Acad Sci USA 100(19):11047–11052CrossRefPubMedPubMedCentral

Tully K, Bolshakov VY (2010) Emotional enhancement of memory: how norepinephrine enables synaptic plasticity. Mol Brain 3:15CrossRefPubMedPubMedCentral

Valentino RJ, Van Bockstaele E (2008) Convergent regulation of locus coeruleus activity as an adaptive response to stress. Eur J Pharmacol 583(2–3):194–203CrossRefPubMedPubMedCentral

Van Bockstaele EJ, Biswas A, Pickel VM (1993) Topography of serotonin neurons in the dorsal raphe nucleus that send axon collaterals to the rat prefrontal cortex and nucleus accumbens. Brain Res 624(1–2):188–198CrossRefPubMed

Van Bockstaele EJ, Colago EE, Cheng P, Moriwaki A, Uhl GR, Pickel VM (1996a) Ultrastructural evidence for prominent distribution of the mu-opioid receptor at extrasynaptic sites on noradrenergic dendrites in the rat nucleus locus coeruleus. J Neurosci 16(16):5037–5048PubMed

Van Bockstaele EJ, Colago EE, Valentino RJ (1996b) Corticotropin-releasing factor-containing axon terminals synapse onto catecholamine dendrites and may presynaptically modulate other afferents in the rostral pole of the nucleus locus coeruleus in the rat brain. J Comp Neurol 364(3):523–534CrossRefPubMed

Van Bockstaele EJ, Colago EE, Valentino RJ (1998) Amygdaloid corticotropin-releasing factor targets locus coeruleus dendrites: substrate for the co-ordination of emotional and cognitive limbs of the stress response. J Neuroendocrinol 10(10):743–757CrossRefPubMed

Vassar R, Bennett BD, Babu-Khan S, Kahn S, Mendiaz EA, Denis P, Teplow DB, Ross S, Amarante P, Loeloff R, Luo Y, Fisher S, Fuller J, Edenson S, Lile J, Jarosinski MA, Biere AL, Curran E, Burgess T, Louis JC, Collins F, Treanor J, Rogers G, Citron M (1999) Beta-secretase cleavage of Alzheimer’s amyloid precursor protein by the transmembrane aspartic protease BACE. Science 286(5440):735–741CrossRefPubMed

Wang ZW (2008) Molecular mechanisms of neurotransmitter Rlease. ebrary Inc., Palo AltoCrossRef

Waterhouse BD, Moises HC, Woodward DJ (1980) Noradrenergic modulation of somatosensory cortical neuronal responses to iontophoretically applied putative neurotransmitters. Exp Neurol 69(1):30–49CrossRefPubMed

Wertkin AM, Turner RS, Pleasure SJ, Golde TE, Younkin SG, Trojanowski JQ, Lee VM (1993) Human neurons derived from a teratocarcinoma cell line express solely the 695-amino acid amyloid precursor protein and produce intracellular beta-amyloid or A4 peptides. Proc Natl Acad Sci USA 90(20):9513–9517CrossRefPubMedPubMedCentral

Xu H, Greengard P, Gandy S (1995) Regulated formation of Golgi secretory vesicles containing Alzheimer beta-amyloid precursor protein. J Biol Chem 270(40):23243–23245CrossRefPubMed

Youmans KL, Tai LM, Kanekiyo T, Stine WB Jr, Michon SC, Nwabuisi-Heath E, Manelli AM, Fu Y, Riordan S, Eimer WA, Binder L, Bu G, Yu C, Hartley DM, LaDu MJ (2012) Intraneuronal Abeta detection in 5xFAD mice by a new Abeta-specific antibody. Mol Neurodegener 7:8CrossRefPubMedPubMedCentral

Yu JT, Wang ND, Ma T, Jiang H, Guan J, Tan L (2011) Roles of beta-adrenergic receptors in Alzheimer’s disease: implications for novel therapeutics. Brain Res Bull 84(2):111–117CrossRefPubMed

Zhou HC, Sun YY, Cai W, He XT, Yi F, Li BM, Zhang XH (2013) Activation of beta2-adrenoceptor enhances synaptic potentiation and behavioral memory via cAMP-PKA signaling in the medial prefrontal cortex of rats. Learn Mem 20(5):274–284CrossRefPubMed

Titel: Localization of endogenous amyloid-β to the coeruleo-cortical pathway: consequences of noradrenergic depletion
verfasst von: Jennifer A. Ross
Beverly A. S. Reyes
Steven A. Thomas
Elisabeth J. Van Bockstaele
Publikationsdatum: 04.08.2017
Verlag: Springer Berlin Heidelberg
Erschienen in: Brain Structure and Function / Ausgabe 1/2018
Print ISSN: 1863-2653
Elektronische ISSN: 1863-2661
DOI: https://doi.org/10.1007/s00429-017-1489-9

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