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01.05.2013 | Original

Long-term outcomes and quality of life in critically ill patients with hematological or solid malignancies: a single center study

verfasst von: S. G. Oeyen, D. D. Benoit, L. Annemans, P. O. Depuydt, S. J. Van Belle, R. I. Troisi, L. A. Noens, P. Pattyn, J. M. Decruyenaere

Erschienen in: Intensive Care Medicine | Ausgabe 5/2013

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Abstract

Purpose

Data concerning long-term outcomes and quality of life (QOL) in critically ill cancer patients are scarce. The aims of this study were to assess long-term outcomes and QOL in critically ill patients with hematological (HM) or solid malignancies (SM) 3 months and 1 year after intensive care unit (ICU) discharge, to compare these with QOL before ICU admission, and to identify prognostic indicators of long-term QOL.

Methods

During a 1 year prospective observational cohort analysis, consecutive patients with HM or SM admitted to the medical or surgical ICU of a university hospital were screened for inclusion. Cancer data, demographics, co-morbidity, severity of illness, organ failures, and outcomes were collected. The QOL before ICU admission, 3 months, and 1 year after ICU discharge was assessed using standardized questionnaires (EuroQoL-5D, Medical Outcomes Study 36-item Short Form Health Survey). Statistical significance was attained at P < 0.05.

Results

There were 483 patients (85 HM, 398 SM) (64 % men) with a median age of 62 years included. Mortality rates of HM compared to SM were, respectively: hospital (34 vs. 13 %), 3 months (42 vs. 17 %), and 1 year (66 vs. 36 %) (P < 0.001). QOL declined at 3 months, but improved at 1 year although it remained under baseline QOL, particularly in HM. Older age (P = 0.007), severe comorbidity (P = 0.035), and HM (P = 0.041) were independently associated with poorer QOL at 1 year.

Conclusions

Long-term outcomes and QOL were poor, particularly in HM. Long-term expectations should play a larger role during multidisciplinary triage decisions upon referral to the ICU.

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Titel: Long-term outcomes and quality of life in critically ill patients with hematological or solid malignancies: a single center study
verfasst von: S. G. Oeyen
D. D. Benoit
L. Annemans
P. O. Depuydt
S. J. Van Belle
R. I. Troisi
L. A. Noens
P. Pattyn
J. M. Decruyenaere
Publikationsdatum: 01.05.2013
Verlag: Springer-Verlag
Erschienen in: Intensive Care Medicine / Ausgabe 5/2013
Print ISSN: 0342-4642
Elektronische ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-012-2791-x

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Long-term outcomes and quality of life in critically ill patients with hematological or solid malignancies: a single center study