Background
Results
AP-2δ is expressed in a subset of RGCs in wild-type mouse retina
Brn3c is a target of AP-2δ in the retina
Reduction in the number of RGCs in AP-2δ−/− mice
RGC axons in AP-2δ−/− mice are able to take a correct path
Structure | Measurement | W4-WT | AE1-WT | AF2-WT | Average | SD | T1-KO | W1-KO | AE2-KO | AF1-KO | Average | SD | KO vs WT; U-test statistics (2-tailed) |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SCN
| Volume contra proj (mm3) | 0.0145 | NA | 0.0130 |
0.0138
|
0.0011
| 0.0114 | 0.0169 | 0.0119 | 0.0132 |
0.0134
|
0.0025
| −2.9 %; NS (P = 0.64) |
Volume ipsi proj (mm3) | 0.0129 | NA | 0.0125 |
0.0127
|
0.0003
| 0.0132 | 0.0119 | 0.0131 | 0.0116 |
0.0125
|
0.0008
| −1.6 %; NS (P = 1) | |
dLGN
| A-P length (max; μm) | 940 | 910 | 1040 |
963
|
68
| 930 | 1022 | 1050 | 1130 |
1033
|
83
| +7.3 %; NS (P = 0.29) |
Lat extension (μm) | 900 | 780 | 720 |
800
|
92
| 750 | 780 | 720 | 750 |
750
|
24
| −6.3 %; NS (P = 0.47) | |
Volume contra proj (mm3) | 0.1583 | 0.1284 | 0.1029 |
0.1299
|
0.0277
| 0.1146 | 0.1412 | 0.1389 | 0.1781 |
0.1432
|
0.0262
| +10 %; NS (P = 0.48) | |
Volume ipsi proj (mm3) | 0.0207 | 0.0126 | 0.0161 |
0.0165
|
0.0041
| 0.0214 | 0.0168 | 0.0211 | 0.0139 |
0.0183
|
0.0036
| +11 %; NS (P = 0.29) | |
Ratio ipsi/contra | 13.08 % | 9.81 % | 15.65 % |
12.85 %
|
2.92 %
| 18.67 % | 11.90 % | 15.19 % | 7.80 % |
13.39 %
|
4.64 %
| +4.2 %; NS (P = 0.16) | |
vLGN
| A-P length (max; μm) | 815 | 591 | 740 |
715
|
114
| 760 | 662 | 566 | 730 |
680
|
86
| −4.9 %; NS (P = 0.48) |
Lat extension (μm) | 450 | 360 | 450 |
420
|
52
| 360 | 450 | 450 | 510 |
443
|
62
| +5.5 %; NS (P = 0.55) | |
Volume contra proj (mm3) | 0.0398 | 0.0407 | 0.0418 |
0.0408
|
0.0010
| 0.0325 | 0.0353 | 0.0383 | 0.0464 |
0.0381
|
0.0060
| −7 %; NS (P = 0.29) | |
Volume ipsi proj (mm3) | 0.00699 | 0.00651 | 0.00668 |
0.00673
|
0.00024
| 0.00656 | 0.00496 | 0.00631 | 0.00449 |
0.00558
|
0.00101
| −17 %; NS (P = 0.077) | |
Ratio ipsi/contra | 17.56 % | 16.00 % | 15.98 % |
16.51 %
|
0.91 %
| 20.18 % | 14.05 % | 16.48 % | 9.68 % |
15.10 %
|
4.41 %
| −8.8 %; NS (P = 0.72) | |
MTN
| Volume contra proj (mm3) | 0.00912 | 0.00755 | 0.00755 |
0.00807
|
0.00091
| 0.0112 | 0.0105 | 0.0096 | 0.00915 |
0.01011
|
0.00092
|
+25.3 %; S (
P
= 0.034)
|
Volume ipsi proj (mm3) | none | none | none | none | none | none | none | ||||||
SC
| A-P length (max; μm) | 2100 | 1770 | 1930 |
1933
|
165
| 1765 | 1815 | 1680 | 1550 |
1703
|
116
| −12 %; NS (P = 0.077) |
Lateral extension (μm) | 1500 | 1530 | 1590 |
1540
|
46
| 1650 | 1620 | 1530 | 1560 |
1590
|
55
| +3.2 %; NS (P = 0.21) | |
Thickness contra proj (max; μm) | 250 | 255 | 270 |
258
|
10
| 195 | 215 | 210 | 220 |
210
|
11
|
−19 %; S (
P
= 0.032)
| |
Volume contra proj (mm3) | 0.526 | 0.454 | 0.504 |
0.495
|
0.037
| 0.315 | 0.414 | 0.302 | 0.321 |
0.338
|
0.051
|
−32 %; S (
P
= 0.034)
| |
Volume ipsi proj (mm3) | 0.00654 | 0.00726 | 0.00817 |
0.00732
|
0.00082
| 0.00127 | 0.00104 | 0.00088 | 0.00051 |
0.00093
|
0.00032
|
−87 % (~8 fold smaller); S (
P
= 0.034)
| |
Ratio ipsi/contra | 1.24 % | 1.60 % | 1.62 % |
1.49 %
|
0.21 %
| 0.40 % | 0.25 % | 0.29 % | 0.16 % |
0.28 %
|
0.10 %
|
−81 % (~5.3 fold smaller); S (
P
= 0.034)
|