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Metabolic Brain Disease

Erschienen in:

09.04.2021 | Review Article

Manifestation of renin angiotensin system modulation in traumatic brain injury

verfasst von: Golnoush Mirzahosseini, Saifudeen Ismael, Heba A. Ahmed, Tauheed Ishrat

Erschienen in: Metabolic Brain Disease | Ausgabe 6/2021

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Abstract

Traumatic brain injury (TBI) alters brain function and is a crucial public health concern worldwide. TBI triggers the release of inflammatory mediators (cytokines) that aggravate cerebral damage, thereby affecting clinical prognosis. The renin angiotensin system (RAS) plays a critical role in TBI pathophysiology. RAS is widely expressed in many organs including the brain. Modulation of the RAS in the brain via angiotensin type 1 (AT₁) and type 2 (AT₂) receptor signaling affects many pathophysiological processes, including TBI. AT₁R is highly expressed in neurons and astrocytes. The upregulation of AT₁R mediates the effects of angiotensin II (ANG II) including release of proinflammatory cytokines, cell death, oxidative stress, and vasoconstriction. The AT₂R, mainly expressed in the fetal brain during development, is also related to cognitive function. Activation of this receptor pathway decreases neuroinflammation and oxidative stress and improves overall cell survival. Numerous studies have illustrated the therapeutic potential of inhibiting AT₁R and activating AT₂R for treatment of TBI with variable outcomes. In this review, we summarize studies that describe the role of brain RAS signaling, through AT₁R and AT₂R in TBI, and its modulation with pharmacological approaches.

Abdul-Muneer P, Bhowmick S, Briski N (2018) Angiotensin II causes neuronal damage in stretch-injured neurons: protective effects of losartan, an angiotensin T 1 receptor blocker. Mol Neurobiol 55:5901–5912PubMed

Abiodun OA, Ola MS (2020) Role of brain renin angiotensin system in neurodegeneration: an update. Saudi J Biol Sci 27:905–912PubMedPubMedCentral

Acosta SA, Tajiri N, de la Pena I, Bastawrous M, Sanberg PR, Kaneko Y, Borlongan CV (2015) Alpha-synuclein as a pathological link between chronic traumatic brain injury and Parkinson's disease. J Cell Physiol 230:1024–1032PubMedPubMedCentral

Annegers JF, Coan SP (2000) The risks of epilepsy after traumatic brain injury. Seizure 9:453–457PubMed

Benicky J, Sánchez-Lemus E, Honda M, Pang T, Orecna M, Wang J, Leng Y, Chuang DM, Saavedra JM (2011) Angiotensin II AT 1 receptor blockade ameliorates brain inflammation. Neuropsychopharmacology 36:857–870PubMed

Chappell MC, Brosnihan KB, Diz DI, Ferrario CM (1989) Identification of angiotensin-(1-7) in rat brain: evidence for differential processing of angiotensin peptides. J Biol Chem 264:16518–16523PubMed

Chiu C-C, Liao YE, Yang LY, Wang JY, Tweedie D, Karnati HK, Greig NH, Wang JY (2016) Neuroinflammation in animal models of traumatic brain injury. J Neurosci Methods 272:38–49PubMedPubMedCentral

Dasgupta C, Zhang L (2011) Angiotensin II receptors and drug discovery in cardiovascular disease. Drug Discov Today 16:22–34. https://doi.org/10.1016/j.drudis.2010.11.016CrossRefPubMed

Dupont AG, Légat L (2020) GABA is a mediator of brain AT 1 and AT 2 receptor-mediated blood pressure responses Hypertens Res:1–11

Feng Y, Xia H, Cai Y, Halabi CM, Becker LK, Santos RAS, Speth RC, Sigmund CD, Lazartigues E (2010) Brain-selective overexpression of human angiotensin-converting enzyme type 2 attenuates neurogenic hypertension. Circ Res 106:373–382PubMed

Finnie J (2013) Neuroinflammation: beneficial and detrimental effects after traumatic brain injury. Inflammopharmacology 21:309–320PubMed

Forrester SJ, Booz GW, Sigmund CD, Coffman TM, Kawai T, Rizzo V, Scalia R, Eguchi S (2018) Angiotensin II signal transduction: an update on mechanisms of physiology and pathophysiology. Physiol Rev 98:1627–1738PubMedPubMedCentral

Fouda AY, Artham S, El-Remessy AB, Fagan SC (2016) Renin–angiotensin system as a potential therapeutic target in stroke and retinopathy: experimental and clinical evidence. Clin Sci 130:221–238

Fountain JH, Lappin SL (2020) Physiology, Renin Angiotensin System. StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK470410/

Ganten D, Minnich JL, Grenger P, Hayduk K, Brecht HM, Barbeau A, Boucher R, Genest J (1971) Angiotensin-forming enzyme in brain tissue. Science 173:64–65PubMed

Hirooka Y, Kimura Y, Nozoe M, Sagara Y, Ito K, Sunagawa K (2006) Amlodipine-induced reduction of oxidative stress in the brain is associated with sympatho-inhibitory effects in stroke-prone spontaneously hypertensive rats. Hypertens Res 29:49–56PubMed

Holownia A, Braszko JJ (2007) The effect of angiotensin II and IV on ERK1/2 and CREB signalling in cultured rat astroglial cells Naunyn-Schmiedeberg's arch Pharmacol 376:157-163

Intebi AD, Flaxman MS, Ganong WF, Deschepper CF (1990) Angiotensinogen production by rat astroglial cells in vitro and in vivo. Neuroscience 34:545–554. https://doi.org/10.1016/0306-4522(90)90163-XCrossRefPubMed

Ito H, Takemori K, Suzuki T (2001) Role of angiotensin II type 1 receptor in the leucocytes and endothelial cells of brain microvessels in the pathogenesis of hypertensive cerebral injury. J Hypertens 19:591–597PubMed

Iwanami J, Mogi M, Tsukuda K, Wang XL, Nakaoka H, Kan-no H, Chisaka T, Bai HY, Shan BS, Kukida M, Horiuchi M (2015) Direct angiotensin II type 2 receptor stimulation by compound 21 prevents vascular dementia. J Am Soc Hypertens 9:250–256PubMed

Jackson L, Eldahshan W, Fagan SC, Ergul A (2018) Within the brain: the renin angiotensin system. Int J Mol Sci 19:876PubMedCentral

Janatpour ZC, Korotcov A, Bosomtwi A, Dardzinski BJ, Symes AJ (2019) Subcutaneous administration of angiotensin-(1-7) improves recovery after traumatic brain injury in mice. J Neurotrauma 36:3115–3131PubMed

Jiang T, Gao L, Guo J, Lu J, Wang Y, Zhang Y (2012) Suppressing inflammation by inhibiting the NF-κB pathway contributes to the neuroprotective effect of angiotensin-(1-7) in rats with permanent cerebral ischaemia. Br J Pharmacol 167:1520–1532. https://doi.org/10.1111/j.1476-5381.2012.02105.xCrossRefPubMedPubMedCentral

Jiang T, Gao L, Shi J, Lu J, Wang Y, Zhang Y (2013) Angiotensin-(1-7) modulates renin–angiotensin system associated with reducing oxidative stress and attenuating neuronal apoptosis in the brain of hypertensive rats. Pharmacol res 67:84–93PubMed

Jiang T et al. (2018) AVE0991, a nonpeptide analogue of Ang-(1-7), attenuates aging-related neuroinflammation aging (Albany NY) 10:645-657 doi:https://doi.org/10.18632/aging.101419

Khaksari M et al (2018) Does inhibition of angiotensin function cause neuroprotection in diffuse traumatic brain injury? Iran J Basic Med Sci 21:615PubMedPubMedCentral

Kiprianova I, Sandkühler J, Schwab S, Hoyer S, Spranger M (1999) Brain-derived neurotrophic factor improves long-term potentiation and cognitive functions after transient forebrain ischemia in the rat. Exp Neurol 159:511–519PubMed

Landmesser U et al. (2002) Role of p47 phox in vascular oxidative stress and hypertension caused by angiotensin II hypertension 40:511-515

Leker RR, Shohami E (2002) Cerebral ischemia and trauma—different etiologies yet similar mechanisms: neuroprotective opportunities. Brain Res Rev 39:55–73PubMed

Li J et al. (2005) Angiotensin AT2 receptor protects against cerebral ischemia-induced neuronal injury FASEB J 19:1-25

Liu M, Shi P, Sumners C (2016) Direct anti-inflammatory effects of angiotensin-(1–7) on microglia. J Neurochem 136:163–171PubMed

Lu J et al. (2013) The expression of angiotensin-converting enzyme 2-angiotensin-(1-7)-mas receptor axis are upregulated after acute cerebral ischemic stroke in rats neuropeptides 47:289-295 doi:https://doi.org/10.1016/j.npep.2013.09.002

Mayeux R, Ottman R, Maestre G, Ngai C, Tang MX, Ginsberg H, Chun M, Tycko B, Shelanski M (1995) Synergistic effects of traumatic head injury and apolipoprotein-epsilon4 in patients with Alzheimer's disease. Neurology 45:555–557PubMed

McKinley MJ et al (2003) The brain renin–angiotensin system: location and physiological roles. Int J Biochem Cell Biol 35:901–918PubMed

Mecca AP, Regenhardt RW, O’Connor TE, Joseph JP, Raizada MK, Katovich MJ, Sumners C (2011) Cerebroprotection by angiotensin-(1–7) in endothelin-1-induced ischaemic stroke. Exp Physiol 96:1084–1096PubMedPubMedCentral

Mogi M, Horiuchi M (2013) Effect of angiotensin II type 2 receptor on stroke, cognitive impairment and neurodegenerative diseases. Geriatr Gerontol Int 13:–13, 18

Nelson LD, Temkin NR, Dikmen S, Barber J, Giacino JT, Yuh E, Levin HS, McCrea MA, Stein MB, Mukherjee P, Okonkwo DO, Robertson CS, Diaz-Arrastia R, Manley GT, and the TRACK-TBI Investigators, Adeoye O, Badjatia N, Boase K, Bodien Y, Bullock MR, Chesnut R, Corrigan JD, Crawford K, Duhaime AC, Ellenbogen R, Feeser VR, Ferguson A, Foreman B, Gardner R, Gaudette E, Gonzalez L, Gopinath S, Gullapalli R, Hemphill JC, Hotz G, Jain S, Korley F, Kramer J, Kreitzer N, Lindsell C, Machamer J, Madden C, Martin A, McAllister T, Merchant R, Noel F, Palacios E, Perl D, Puccio A, Rabinowitz M, Rosand J, Sander A, Satris G, Schnyer D, Seabury S, Sherer M, Taylor S, Toga A, Valadka A, Vassar MJ, Vespa P, Wang K, Yue JK, Zafonte R (2019) Recovery After Mild Traumatic Brain Injury in Patients Presenting to US Level I Trauma Centers: A Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI). Study JAMA Neurol 76:1049–1059. https://doi.org/10.1001/jamaneurol.2019.1313CrossRefPubMed

Nguyen R et al (2016) The international incidence of traumatic brain injury: a systematic review and meta-analysis can. J Neurol Sci 43:774–785

Ozacmak VH, Sayan H, Cetin A, Akyıldız-Igdem A (2007) AT1 receptor blocker candesartan-induced attenuation of brain injury of rats subjected to chronic cerebral hypoperfusion. Neurochem res 32:1314–1321PubMed

Paz Ocaranza M, Riquelme JA, García L, Jalil JE, Chiong M, Santos RAS, Lavandero S (2020) Counter-regulatory renin–angiotensin system in cardiovascular disease. Nature Reviews Cardiology 17:116–129. https://doi.org/10.1038/s41569-019-0244-8CrossRefPubMed

Pelisch N et al (2010) Systemic candesartan reduces brain angiotensin II via downregulation of brain renin–angiotensin system. Hypertens Res 33:161PubMed

Phillips MI, De Oliveira EM (2008) Brain renin angiotensin in disease. J Mol Med 86:715–722PubMed

Prasetyo E (2020) The primary, secondary, and tertiary brain injury Crit care. Shock 23:4–13

Rodriguez-Perez AI, Borrajo A, Rodriguez-Pallares J, Guerra MJ, Labandeira-Garcia JL (2015) Interaction between NADPH-oxidase and R ho-kinase in angiotensin II-induced microglial activation. Glia 63:466–482PubMed

Rueckschloss U, Quinn MT, Holtz J, Morawietz H (2002) Dose-dependent regulation of NAD (P) H oxidase expression by angiotensin II in human endothelial cells: protective effect of angiotensin II type 1 receptor blockade in patients with coronary artery disease. Arterioscler Thromb Vasc Biol 22:1845–1851PubMed

Saavedra JM (1992) Brain and pituitary angiotensin. Endocr Rev 13:329–380PubMed

Saavedra JM (2005) Brain angiotensin II: new developments, unanswered questions and therapeutic opportunities cell. Mol Neurobiol 25:485–512

Saavedra JM (2012) Angiotensin II AT1 receptor blockers as treatments for inflammatory brain disorders. Clin Sci 123:567–590

Saavedra JM, Sánchez-Lemus E, Benicky J (2011) Blockade of brain angiotensin II AT1 receptors ameliorates stress, anxiety, brain inflammation and ischemia: therapeutic implications. Psychoneuroendocrinology 36:1–18PubMed

Sigmund CD, Grobe JL (2020) A colorful view of the brain renin–angiotensin system. Hypertens Res 43:357–359PubMedPubMedCentral

Taylor CA, Bell JM, Breiding MJ, Xu L (2017) Traumatic brain injury–related emergency department visits, hospitalizations, and deaths—United States, 2007 and 2013 MMWR Surveill Summ 66:1

Timaru-Kast R, Gotthardt P, Luh C, Huang C, Hummel R, Schäfer MK, Thal SC (2019) Angiotensin II receptor 1 blockage limits brain damage and improves functional outcome after brain injury in aged animals despite age-dependent reduction in AT1 expression front aging. Neurosci 11:–63

Timaru-Kast R et al (2012) Delayed inhibition of angiotensin II receptor type 1 reduces secondary brain damage and improves functional recovery after experimental brain trauma. Crit care med 40:935–944PubMed

Torika N, Asraf K, Apte RN, Fleisher-Berkovich S (2018) Candesartan ameliorates brain inflammation associated with Alzheimer's disease CNS Neurosci Ther 24:231–242. https://doi.org/10.1111/cns.12802CrossRefPubMed

Umschweif G, Liraz-Zaltsman S, Shabashov D, Alexandrovich A, Trembovler V, Horowitz M, Shohami E (2014a) Angiotensin receptor type 2 activation induces neuroprotection and neurogenesis after traumatic brain injury. Neurotherapeutics 11:665–678PubMedPubMedCentral

Umschweif G, Shabashov D, Alexandrovich AG, Trembovler V, Horowitz M, Shohami E (2014b) Neuroprotection after traumatic brain injury in heat-acclimated mice involves induced neurogenesis and activation of angiotensin receptor type 2 signaling. J Cereb blood flow Metab 34:1381–1390PubMedPubMedCentral

Unger T, Dahlöf B (2010) Compound 21, the first orally active, selective agonist of the angiotensin type 2 receptor (AT2): implications for AT2 receptor research and therapeutic potential. J Renin-Angiotensin-Aldosterone Syst 11:75–77PubMed

Vadhan JD, Speth RC (2020) The role of the brain renin-angiotensin system (RAS) in mild traumatic brain injury (TBI) Pharmacol Ther:107684

Villapol S, Balarezo MG, Affram K, Saavedra JM, Symes AJ (2015) Neurorestoration after traumatic brain injury through angiotensin II receptor blockage. Brain 138:3299–3315PubMedPubMedCentral

Villapol S, Yaszemski AK, Logan TT, Sánchez-Lemus E, Saavedra JM, Symes AJ (2012) Candesartan, an angiotensin II AT 1-receptor blocker and PPAR-γ agonist, reduces lesion volume and improves motor and memory function after traumatic brain injury in mice. Neuropsychopharmacology 37:2817–2829PubMedPubMedCentral

Volpe M, Savoia C, De Paolis P, Ostrowska B, Tarasi D, Rubattu S (2002) The renin-angiotensin system as a risk factor and therapeutic target for cardiovascular and renal disease. J Am Soc Nephrol 13:S173–S178PubMed

Werhane ML et al (2017) Pathological vascular and inflammatory biomarkers of acute-and chronic-phase traumatic brain injury. Concussion 2:CNC30PubMedPubMedCentral

Werner C, Engelhard K (2007) Pathophysiology of traumatic brain injury. Br J Anaesth 99:4–9PubMed

Wright JW, Harding JW (2004) The brain angiotensin system and extracellular matrix molecules in neural plasticity, learning, and memory. Prog Neurobiol 72:263–293PubMed

Yaka R et al. (2007) D-cycloserine improves functional recovery and reinstates long-term potentiation (LTP) in a mouse model of closed head injury FASEB J 21:2033-2041

Zhang Y et al. (2008) Central administration of angiotensin-(1-7) stimulates nitric oxide release and upregulates the endothelial nitric oxide synthase expression following focal cerebral ischemia/reperfusion in rats neuropeptides 42:593-600 doi:https://doi.org/10.1016/j.npep.2008.09.005

Zheng J, Li G, Chen S, Bihl J, Buck J, Zhu Y, Xia H, Lazartigues E, Chen Y, Olson JE (2014) Activation of the ACE2/Ang-(1-7)/mas pathway reduces oxygen-glucose deprivation-induced tissue swelling. ROS production, and cell death in mouse brain with angiotensin II overproduction Neuroscience 273:39–51. https://doi.org/10.1016/j.neuroscience.2014.04.060CrossRefPubMed

Titel: Manifestation of renin angiotensin system modulation in traumatic brain injury
verfasst von: Golnoush Mirzahosseini
Saifudeen Ismael
Heba A. Ahmed
Tauheed Ishrat
Publikationsdatum: 09.04.2021
Verlag: Springer US
Erschienen in: Metabolic Brain Disease / Ausgabe 6/2021
Print ISSN: 0885-7490
Elektronische ISSN: 1573-7365
DOI: https://doi.org/10.1007/s11011-021-00728-1

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