Erschienen in:
11.10.2021 | Pain Medicine (GJ Meredith, Section Editor)
Mechanisms, Diagnosis, and Medical Management of Hyperalgesia: an Educational Review
verfasst von:
Sylvia H. Wilson, Kevin M. Hellman, Dominika James, Adam C. Adler, Arvind Chandrakantan
Erschienen in:
Current Anesthesiology Reports
|
Ausgabe 4/2021
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Abstract
Purpose of the Review
Hyperalgesia may be an iatrogenic consequence of surgery or pain management. Thus, it is essential for anesthesiologists, pain management specialists, surgeons, and primary care physicians to regularly update their awareness and strategies for addressing this problem. This educational review of hyperalgesia provides up-to-date knowledge of the contributing mechanisms, differential diagnoses, and medical therapy. A particular focus is placed on common types of postoperative hyperalgesia and recent evidence that anesthesiologists and surgeons should be aware of.
Recent Findings
Hyperalgesia may acutely manifest due to tissue injury and peripheral sensitization; it can progress to a chronic condition developing from central nervous system sensitization. While clinical evaluation begins with a detailed history, physical examination, and sensory testing, an improved understanding of the clinical and cellular mechanisms involved in hyperalgesia pathology continues to drive future research and advance our understanding of this complex presentation.
Summary
Opioid-induced hyperalgesia may be confused with opioid tolerance and withdrawal and must also be differentiated from other diagnoses to optimize patient management and promote disease regression. Hyperalgesia is a common clinical condition with evolving guidelines for testing and treatment. Opioid-induced hyperalgesia is a potential cause of hyperalgesia and must be differentiated to optimize therapeutic decision-making.