Skip to main content
Hauptrubriken
CME Facharzt-Training Webinare Zeitschriften Bücher e.Medpedia Podcast
Service
Jobbörse Info & Hilfe
Fachgebiete
Anästhesiologie Allgemeinmedizin Arbeitsmedizin Augenheilkunde Chirurgie Dermatologie Gynäkologie und Geburtshilfe HNO Innere Medizin Kardiologie Neurologie Onkologie und Hämatologie Orthopädie und Unfallchirurgie Pädiatrie Pathologie Psychiatrie Radiologie Rechtsmedizin Urologie Zahnmedizin
Themen
Klimawandel und Gesundheit Neues aus dem Markt COVID-19 Praxis und Beruf Seltene Erkrankungen GOÄ & EBM Panorama
Sammlungen
Kasuistiken Algorithmen & Infografiken Blickdiagnosen Arthropedia FlapFinder (für Dermatochirurgen) Videos Kongressberichterstattung Medizin für Apothekerinnen und Apotheker Für Ärztinnen und Ärzte in Weiterbildung Für Medizinstudierende
Erweiterte Suche
Anmelden
nach oben
Skeletal Radiology
Erschienen in: Skeletal Radiology 10/2007

01.10.2007 | Perspective

Mesenchymal stem and progenitor cells for cartilage repair

verfasst von: Nazish Ahmed, William L. Stanford, Rita A. Kandel

Erschienen in: Skeletal Radiology | Ausgabe 10/2007

Einloggen, um Zugang zu erhalten

Excerpt

Treatment of damaged articular cartilage is problematic due in part to the avascularity of the tissue. Regenerative medicine and tissue engineering offer new approaches for the repair or replacement of damaged or diseased tissue. There is now proof-of-concept to support cell-based regeneration of cartilage, but one of the major issues limiting its use clinically is the availability of a cell source that will form sufficient amounts of tissue comparable to in vivo cartilage both in composition and in mechanical properties. One possible option is to use stem and progenitor cells. This perspective will describe the promise and limitations of the use of stem cells for cartilage repair. …
Literatur
1.
Hunziker EB. Articular cartilage repair: basic science and clinical progress. A review of the current status and prospects. Osteoarthr Cartil 2002; 10: 432–463.PubMedCrossRef
2.
Hunziker EB. Articular cartilage repair: problems and perspectives. Biorheology 2000; 37: 163–164.PubMed
3.
Kinner B, Capito RM, Spector M. Regeneration of articular cartilage. Adv Biochem Eng Biotechnol 2005; 94: 91–123.PubMed
4.
Boyle J, Luan B, Cruz TF, et al. Characterization of proteoglycan accumulation during formation of cartilagenous tissue in vitro. Osteoarthr Cartil 1995; 3: 117–125.PubMedCrossRef
5.
Chuma H, Mizuta H, Kudo S, et al. One day exposure to FGF-2 was sufficient for the regenerative repair of full-thickness defects of articular cartilage in rabbits. Osteoarthr Cartil 2004; 12: 834–842.PubMedCrossRef
6.
Brittberg M, Lindahl A, Nilsson A, et al. Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation. N Engl J Med 1994; 331: 889–895.PubMedCrossRef
7.
zur Nieden NI, Kempka G, Rancourt DE, et al. Induction of chondro-, osteo- and adipogenesis in embryonic stem cells by bone morphogenetic protein-2: effect of cofactors on differentiating lineages. BMC Dev Biol 2005; 5: 1.PubMedCrossRef
8.
Vats A, Bielby RC, Tolley N, et al. Chondrogenic differentiation of human embryonic stem cells: the effect of the micro-environment. Tissue Eng 2006; 12: 1687–1697.PubMedCrossRef
9.
Kramer J, Hargus G, Rohwedel J. Derivation and characterization of chondrocytes from embryonic stem cells in vitro. Methods Mol Biol 2006; 330: 171–190.PubMed
10.
De Coppi P, Bartsch G Jr, Siddiqui MM, et al. Isolation of amniotic stem cell lines with potential for therapy. Nat Biotechnol 2007; 25: 100–106.PubMedCrossRef
11.
Kim J, Lee Y, Kim H, et al. Human amniotic fluid-derived stem cells have characteristics of multipotent stem cells. Cell Prolif 2007; 40: 75–90.PubMedCrossRef
12.
Pittenger MF, Mackay AM, Beck SC, et al. Multilineage potential of adult human mesenchymal stem cells. Science 1999; 284: 143–147.PubMedCrossRef
13.
Caplan AI. Review: mesenchymal stem cells: cell-based reconstructive therapy in orthopedics. Tissue Eng 2005; 11: 1198–1211.PubMedCrossRef
14.
Dominici M, Le Blanc K, Mueller I, et al. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 2006; 8: 315–317.PubMedCrossRef
15.
Horwitz EM, Le Blanc K, Dominici M, et al. Clarification of the nomenclature for MSC: the international society for cellular therapy position statement. Cytotherapy 2005; 7: 393–395.PubMedCrossRef
16.
Friedenstein AJ, Gorskaja JF, Kulagina NN. Fibroblast precursors in normal and irradiated mouse hematopoietic organs. Exp Hematol 1976; 4: 267–274.PubMed
17.
Liechty KW, MacKenzie TC, Shaaban AF, et al. Human mesenchymal stem cells engraft and demonstrate site-specific differentiation after in utero transplantation in sheep. Nat Med 2000; 6: 1282–1286.PubMedCrossRef
18.
Otto WR, Rao J. Tomorrow’s skeleton staff: mesenchymal stem cells and the repair of bone and cartilage. Cell Prolif 2004; 37: 97–110.PubMedCrossRef
19.
Leo AJ, Grande DA. Mesenchymal stem cells in tissue engineering. Cells Tissues Organs 2006; 183: 112–122.PubMedCrossRef
20.
Baksh D, Song L, Tuan RS. Adult mesenchymal stem cells: characterization, differentiation, and application in cell and gene therapy. J Cell Mol Med 2004; 8: 301–316.PubMedCrossRef
21.
Sakaguchi Y, Sekiya I, Yagishita K, et al. Comparison of human stem cells derived from various mesenchymal tissues: superiority of synovium as a cell source. Arthritis Rheum 2005; 52: 2521–2529.PubMedCrossRef
22.
Im GI, Shin YW, Lee KB. Do adipose tissue-derived mesenchymal stem cells have the same osteogenic and chondrogenic potential as bone marrow-derived cells? Osteoarthr Cartil 2005; 13: 845–853.PubMedCrossRef
23.
Huang JI, Kazmi N, Durbhakula MM, et al. Chondrogenic potential of progenitor cells derived from human bone marrow and adipose tissue: a patient-matched comparison. J Orthop Res 2005; 23: 1383–1389.PubMed
24.
Mochizuki T, Muneta T, Sakaguchi Y, et al. Higher chondrogenic potential of fibrous synovium- and adipose synovium-derived cells compared with subcutaneous fat-derived cells: distinguishing properties of mesenchymal stem cells in humans. Arthritis Rheum 2006; 54: 843–853.PubMedCrossRef
25.
Yoshimura H, Muneta T, Nimura A, et al. Comparison of rat mesenchymal stem cells derived from bone marrow, synovium, periosteum, adipose tissue, and muscle. Cell Tissue Res 2007; 327: 449–462.PubMedCrossRef
26.
Song L, Tuan RS. Transdifferentiation potential of human mesenchymal stem cells derived from bone marrow. FASEB J 2004; 18: 980–982.PubMed
27.
Terada N, Hamazaki T, Oka M, et al. Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion. Nature 2002; 416: 542–545.PubMedCrossRef
28.
Fickert S, Fiedler J, Brenner RE. Identification of subpopulations with characteristics of mesenchymal progenitor cells from human osteoarthritic cartilage using triple staining for cell surface markers. Arthritis Res Ther 2004; 6: R422–R432.PubMedCrossRef
29.
Dowthwaite GP, Bishop JC, Redman SN, et al. The surface of articular cartilage contains a progenitor cell population. J Cell Sci 2004; 117: 889–897.PubMedCrossRef
30.
Le Blanc K. Mesenchymal stromal cells: tissue repair and immune modulation. Cytotherapy 2006; 8: 559–561.PubMedCrossRef
31.
Alsalameh S, Amin R, Gemba T, et al. Identification of mesenchymal progenitor cells in normal and osteoarthritic human articular cartilage. Arthritis Rheum 2004; 50: 1522–1532.PubMedCrossRef
32.
Bonyadi M, Waldman SD, Liu D, et al. Mesenchymal progenitor self-renewal deficiency leads to age-dependent osteoporosis in Sca-1/Ly-6A null mice. Proc Natl Acad Sci USA 2003; 100: 5840–5845.PubMedCrossRef
33.
Kafienah W, Mistry S, Dickinson SC, et al. Three-dimensional cartilage tissue engineering using adult stem cells from osteoarthritis patients. Arthritis Rheum 2007; 56: 177–187.PubMedCrossRef
34.
Robinson D, Nevo Z. Articular cartilage chondrocytes are more advantageous for generating hyaline-like cartilage than mesenchymal cells isolated from microfracture repairs. Cell Tissue Bank 2001; 2: 23–30.PubMedCrossRef
35.
Huang JI, Durbhakula MM, Angele P, et al. Lunate arthroplasty with autologous mesenchymal stem cells in a rabbit model. J Bone Joint Surg Am 2006; 88: 744–752.PubMedCrossRef
36.
Shao X, Goh JC, Hutmacher DW, et al. Repair of large articular osteochondral defects using hybrid scaffolds and bone marrow-derived mesenchymal stem cells in a rabbit model. Tissue Eng 2006; 12: 1539–1551.PubMedCrossRef
37.
Wakitani S, Imoto K, Yamamoto T, et al. Human autologous culture expanded bone marrow mesenchymal cell transplantation for repair of cartilage defects in osteoarthritic knees. Osteoarthritis Cartilage 2002; 10: 199–206.PubMedCrossRef
Metadaten
Titel
Mesenchymal stem and progenitor cells for cartilage repair
verfasst von
Nazish Ahmed
William L. Stanford
Rita A. Kandel
Publikationsdatum
01.10.2007
Verlag
Springer-Verlag
Erschienen in
Skeletal Radiology / Ausgabe 10/2007
Print ISSN: 0364-2348
Elektronische ISSN: 1432-2161
DOI
https://doi.org/10.1007/s00256-007-0333-3

Weitere Artikel der Ausgabe 10/2007

Skeletal Radiology 10/2007 Zur Ausgabe

Test Yourself

Painless lump on the shin: presentation

Scientific Article

Stress fractures of the ribs in elite competitive rowers: a report of nine cases

Scientific Article

MRI as a problem-solving tool in unexplained failed total hip replacement following conventional assessment

Scientific Article

MR imaging characteristics in primary lymphoma of bone with emphasis on non-aggressive appearance

Scientific Article

Magnetic resonance imaging in the evaluation of osteochondritis dissecans of the patella

Test Yourself

Painless lump on the shin: diagnosis and discussion

Neu im Fachgebiet Radiologie

Screening-Mammografie offenbart erhöhtes Herz-Kreislauf-Risiko

26.04.2024 Mammografie Nachrichten

Routinemäßige Mammografien helfen, Brustkrebs frühzeitig zu erkennen. Anhand der Röntgenuntersuchung lassen sich aber auch kardiovaskuläre Risikopatientinnen identifizieren. Als zuverlässiger Anhaltspunkt gilt die Verkalkung der Brustarterien.

S3-Leitlinie zu Pankreaskrebs aktualisiert

23.04.2024 Pankreaskarzinom Nachrichten

Die Empfehlungen zur Therapie des Pankreaskarzinoms wurden um zwei Off-Label-Anwendungen erweitert. Und auch im Bereich der Früherkennung gibt es Aktualisierungen.

Fünf Dinge, die im Kindernotfall besser zu unterlassen sind

18.04.2024 Pädiatrische Notfallmedizin Nachrichten

Im Choosing-Wisely-Programm, das für die deutsche Initiative „Klug entscheiden“ Pate gestanden hat, sind erstmals Empfehlungen zum Umgang mit Notfällen von Kindern erschienen. Fünf Dinge gilt es demnach zu vermeiden.

„Nur wer sich gut aufgehoben fühlt, kann auch für Patientensicherheit sorgen“

13.04.2024 Klinik aktuell Kongressbericht

Die Teilnehmer eines Forums beim DGIM-Kongress waren sich einig: Fehler in der Medizin sind häufig in ungeeigneten Prozessen und mangelnder Kommunikation begründet. Gespräche mit Patienten und im Team können helfen.

Update Radiologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen
Bildnachweise