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01.02.2014 | Case Report

Metastatic melanoma mimicking solitary fibrous tumor: report of two cases

verfasst von: Elise M. Bekers, Adriana C. H. van Engen-van Grunsven, Patricia J. T. A. Groenen, Harm Westdorp, Rutger H. T. Koornstra, Johannes J. Bonenkamp, Uta Flucke, Willeke A. M. Blokx

Erschienen in: Virchows Archiv | Ausgabe 2/2014

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Abstract

Malignant melanomas are known for their remarkable morphological variation and aberrant immunophenotype with loss of lineage-specific markers, especially in recurrences and metastases. Hot spot mutations in BRAF, NRAS, GNAQ, and GNA11 and mutations in KIT are oncogenic events in melanomas. Therefore, genotyping can be a useful ancillary diagnostic tool. We present one case each of recurrent and metastatic melanoma, both showing histological and immunohistochemical features of solitary fibrous tumor (SFT). Mutational analysis detected BRAF and NRAS mutations in the primary and secondary lesions, respectively. This result confirmed the diagnosis of recurrent/metastastic melanoma.

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Titel: Metastatic melanoma mimicking solitary fibrous tumor: report of two cases
verfasst von: Elise M. Bekers
Adriana C. H. van Engen-van Grunsven
Patricia J. T. A. Groenen
Harm Westdorp
Rutger H. T. Koornstra
Johannes J. Bonenkamp
Uta Flucke
Willeke A. M. Blokx
Publikationsdatum: 01.02.2014
Verlag: Springer Berlin Heidelberg
Erschienen in: Virchows Archiv / Ausgabe 2/2014
Print ISSN: 0945-6317
Elektronische ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-014-1542-5

Neu im Fachgebiet Pathologie

Open Access 15.04.2024 | Biomarker | Schwerpunkt: Next Generation Pathology

Springer Medizin

Metastatic melanoma mimicking solitary fibrous tumor: report of two cases

Abstract

Neu im Fachgebiet Pathologie

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Personalisierte Medizin in der Onkologie

Springer Medizin

Abstract

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