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Erschienen in:
23.07.2019 | Editorial
Micronutrient deficiency in critical illness: an invisible foe?
Erschienen in: Intensive Care Medicine | Ausgabe 8/2019
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In critical illness, clinical features such as encephalopathy, muscle weakness, peripheral neuropathy, skin and mucosal lesions, and protracted organ dysfunction dominate the clinical picture (Fig. 1) Micronutrient deficiencies—reviewed in this viewpoint article—might contribute to this clinical phenotype and may, moreover, compromise acute outcome.
Fig. 1
Visual abstract aggregating potential impact of premorbid exposure, ICU therapies and disease on micronutrient levels, the cellular metabolic role of these micronutrients, and potential contribution of their deficiency to the clinical features of prolonged critical illness (encephalopathy, muscle weakness and neuropathy, stomatitis, skin tears and dermatitis, delayed wound healing, low cardiac output, and recurrent infections). PN parenteral nutrition, EN enteral nutrition, CRRT continuous renal replacement therapy, RER rough endoplasmatic reticulum, DNA DeoxyriboNucleic acid, RNA RiboNucleic acid
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