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01.10.2014 | Original Article

miR-338-3p is over-expressed in blood, CFS, serum and spinal cord from sporadic amyotrophic lateral sclerosis patients

verfasst von: Bruna De Felice, Anna Annunziata, Giuseppe Fiorentino, Marco Borra, Elio Biffali, Cinzia Coppola, Roberto Cotrufo, Johannes Brettschneider, Maria Luisa Giordana, Tamas Dalmay, Guy Wheeler, Raffaella D’Alessandro

Erschienen in: Neurogenetics | Ausgabe 4/2014

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Abstract

Amyotrophic lateral sclerosis (ALS) is a progressive and seriously disabling adult-onset neurological disease. Ninety percent of ALS patients are sporadic cases (sALS) with no clear genetic linkage. Accumulating evidence indicates that various microRNAs (miRNAs), expressed in a spatially and temporally controlled manner in the brain, play a key role in neuronal development. In addition, microRNA dysregulation contributes to some mental disorders and neurodegeneration diseases. In our research, the expression of one selected miRNA, miR-338-3p, which previously we have found over-expressed in blood leukocytes, was studied in several different tissues from sALS patients. For the first time, we detected a specific microRNA disease-related upregulation, miR-338-3p, in blood leukocytes as well in cerebrospinal fluid, serum, and spinal cord from sALS patients. Besides, staining of in situ hybridization showed that the signals of miR-338-3p were localized in the grey matter of spinal cord tissues from sALS autopsied patients. We propose that miRNA profiles found in tissue samples from sALS patients can be relevant to understand sALS pathogenesis and lead to set up effective biomarkers for sALS early diagnosis.

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Titel: miR-338-3p is over-expressed in blood, CFS, serum and spinal cord from sporadic amyotrophic lateral sclerosis patients
verfasst von: Bruna De Felice
Anna Annunziata
Giuseppe Fiorentino
Marco Borra
Elio Biffali
Cinzia Coppola
Roberto Cotrufo
Johannes Brettschneider
Maria Luisa Giordana
Tamas Dalmay
Guy Wheeler
Raffaella D’Alessandro
Publikationsdatum: 01.10.2014
Verlag: Springer Berlin Heidelberg
Erschienen in: Neurogenetics / Ausgabe 4/2014
Print ISSN: 1364-6745
Elektronische ISSN: 1364-6753
DOI: https://doi.org/10.1007/s10048-014-0420-2

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