Erschienen in:
27.07.2016 | Review Article
Molecular Landscape and Treatment Options for Patients with Metastatic Colorectal Cancer
verfasst von:
Yuji Miyamoto, Wu Zhang, Heinz-Josef Lenz
Erschienen in:
Indian Journal of Surgical Oncology
|
Ausgabe 4/2017
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Abstract
Over the last 20 years, median survival for patients with metastatic colorectal cancer (CRC) has remarkably improved from about 12 to over 30 months, mainly because of the development of new agents and patient selection using predictive biomarkers. However, the identification of the most effective treatment for an individual patient is still a challenge. Molecular profiling of CRC has made great progress, but it is limited by tumor heterogeneity and absence of driver mutation. However, RAS, BRAF, and microsatellite instability are validated biomarker recommended by NCCN and ESMO. In this review, we discuss recent advances and future developments.