Introduction
Materials and methods
Clinico-pathological features | Total (52) | [%] | |
---|---|---|---|
Sex | 30M 22F | ||
Age | 46.1 ± 24.0 | ||
Dimension (cm) | 2.2 ± 1.3 | ||
Differentiation | WD | 49 | [94.2] |
PD | 3 | [5.8] | |
Grade | G1 | 36 | [69.2] |
G2 | 13 | [25.0] | |
G3 | 3 | [5.8] | |
Stage UICC/ENETS | IIIB | 22 | [42.3] |
IV | 30 | [57.7] | |
R | R1 | 4 | [7.7] |
R0 | 48 | [92.3] | |
Vascular invasion | Present | 35 | [67.3] |
Absent | 17 | [32.7] | |
Perineural invasion | Present | 32 | [61.5] |
Absent | 20 | [38.5] | |
Necrosis | Present | 3 | [5.8] |
Absent | 49 | [94.2] |
Results
GENE | Total (52) | [%] | M | N | S | D | F |
---|---|---|---|---|---|---|---|
APC
| 4 | [7.7] | 1 | 3 | – | – | – |
ATRX
| 1 | [1.9] | – | – | 1 | – | – |
BRAF
| 2 | [3.8] | 2 | – | – | – | – |
CDKN1B
| 5 | [9.6] | 2 | 1 | – | – | 2 |
CDKN2C/INK4C
| 4 | [7.7] | 3 | – | 1 | – | – |
CTNNB1
| 1 | [1.9] | 1 | – | – | – | – |
FBXW7
| 1 | [1.9] | 1 | – | – | – | – |
FGFR3
| 1 | [1.9] | 1 | – | – | – | – |
GNAS
| 1 | [1.9] | 1 | – | – | – | – |
KRAS
| 2 | [3.8] | 2 | – | – | – | – |
PIK3CA
| 2 | [3.8] | 1 | 1 | – | – | – |
RB1
| 1 | [1.9] | – | – | 1 | – | – |
SRC
| 1 | [1.9] | – | 1 | – | – | – |
TERT
| 1 | [1.9] | 1 | – | – | – | – |
TP53
| 2 | [3.8] | 2 | – | – | – | – |
Gene | Chromosomal location | Gain or loss | Total (52) | [%] |
---|---|---|---|---|
AKT1
| 14 | Gain | 16 | [30.8] |
APC
| 5 | LOH | 2 | [3.8] |
AURKA
| 20 | Gain | 6 | [11.5] |
BCL2
| 18 | LOH | 22 | [42.3] |
BCL2L2
| 14 | Gain | 11 | [21.2] |
BRAF
| 7 | Gain | 9 | [17.3] |
CDH1
| 16 | LOH | 8 | [15.4] |
CDH19
| 18 | LOH | 24 | [46.2] |
CDKN1B
| 12 | LOH | 7 | [13.5] |
CDKN2A
| 9 | LOH | 3 | [5.8] |
DCC
| 18 | LOH | 22 | [42.3] |
EGFR
| 7 | Gain | 4 | [7.7] |
ERBB2
| 17 | Gain | 0 | [0] |
FBXW7
| 4 | LOH | 1 | [1.9] |
FGFR3
| 4 | Gain | 3 | [5.8] |
FHIT
| 3 | LOH | 3 | [5.8] |
FOS
| 14 | Gain | 19 | [36.5] |
GNAS
| 20 | Gain | 5 | [9.6] |
HRAS
| 11 | LOH | 9 | [17.3] |
KDR
| 4 | Gain | 15 | [28.8] |
KIT
| 4 | Gain | 15 | [28.8] |
MAP2K2
| 19 | Gain | 11 | [21.2] |
MDM2
| 12 | Gain | 3 | [5.8] |
MEN1
| 11 | LOH | 7 | [13.5] |
MET
| 7 | Gain | 9 | [17.3] |
MYC
| 8 | Gain | 2 | [3.8] |
MYCL1
| 1 | Gain | 6 | [11.5] |
PDGFRA
| 4 | Gain | 15 | [28.8] |
PIK3CA
| 3 | Gain | 0 | [0] |
PIK3CD
| 1 | LOH | 0 | [0] |
PTEN
| 10 | LOH | 2 | [3.8] |
RICTOR
| 5 | Gain | 2 | [3.8] |
SDHA
| 5 | Gain | 15 | [28.8] |
SDHB
| 1 | LOH | 0 | [0] |
SDHD
| 16 | LOH | 18 | [34.6] |
SMAD4
| 18 | LOH | 15 | [28.8] |
SMAD5
| 5 | Gain | 11 | [21.2] |
SOX12
| 20 | Gain | 7 | [13.5] |
SRC
| 20 | Gain | 13 | [25.0] |
TP53
| 17 | LOH | 0 | [0] |