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01.10.2014 | Review

Nestin involvement in tissue injury and cancer - a potential tumor marker?

verfasst von: Ekaterini Christina Tampaki, Lydia Nakopoulou, Athanasios Tampakis, Konstantinos Kontzoglou, Walter P. Weber, Gregory Kouraklis

Erschienen in: Cellular Oncology | Ausgabe 5/2014

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Abstract

Background

In eukaryotic cells, the cytoskeleton contains three major filamentous components: actin microfilaments, microtubules and intermediate filaments. Nestin represents one of the class VI intermediate filament proteins. Clinical and molecular analyses have revealed substantial information regarding the presence of Nestin in cells with progenitor or stem cell properties. During tissue injury Nestin is expressed in cells with progenitor cell-like properties. These cells may serve as a tissue reserve and, as such, may contribute to tissue repair. Based on currently available data, Nestin also appears to be implicated in two oncogenic processes. First, Nestin has been found to be expressed in cancer stem-like cells and poorly differentiated cancer cells and, as such, Nestin is thought to contribute to the aggressive behavior of these cells. Second, Nestin has been found to be involved in tumor angiogenesis through an interaction of cancer cells and blood vessel endothelial cells and, as such, Nestin is thought to facilitate tumor growth.

Conclusions

We conclude that Nestin may serve as a promising tumor marker and as a potential therapeutic target amenable to tumor suppression and angiogenesis inhibition.

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Titel: Nestin involvement in tissue injury and cancer - a potential tumor marker?
verfasst von: Ekaterini Christina Tampaki
Lydia Nakopoulou
Athanasios Tampakis
Konstantinos Kontzoglou
Walter P. Weber
Gregory Kouraklis
Publikationsdatum: 01.10.2014
Verlag: Springer Netherlands
Erschienen in: Cellular Oncology / Ausgabe 5/2014
Print ISSN: 2211-3428
Elektronische ISSN: 2211-3436
DOI: https://doi.org/10.1007/s13402-014-0193-5

Springer Medizin

Nestin involvement in tissue injury and cancer - a potential tumor marker?

Abstract

Background

Conclusions

Neu im Fachgebiet Pathologie

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Personalisierte Medizin in der Onkologie

Springer Medizin

Abstract

Background

Conclusions

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