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01.12.2017 | Geriatric Anesthesia (S Akhtar, Section Editor) | Ausgabe 4/2017

Neuronal Connectivity, General Anesthesia, and the Elderly

Zeitschrift:: Current Anesthesiology Reports > Ausgabe 4/2017

Autor:: Ramachandran Ramani

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Wichtige Hinweise

This article is part of the Topical Collection on Geriatric Anesthesia

Abstract

Purpose of Review

Due to change in demography, 33% of surgeries carried out are in geriatric patients, of which many develop POD and POCD with its major health care and public health consequences. This review will focus on functional connectivity in the brain, its pathophysiological changes with aging and anesthesia, and the consequent effects on brain function.

Recent Findings

Among the RSNs in the brain, DMN activity is significantly altered in in the aging brain and this correlates with the commonly observed mental function changes. Propofol and sevoflurane also affect DMN activity in young healthy subjects. While aging affects the anterior part of the DMN (frontal lobe regions), anesthesia affects activity in the posterior part (PCC, precuneus and, inferior parietal lobe).

Summary

Understanding the effect of surgery and anesthesia on connectivity in elderly is essential in order to be able to optimize brain function after surgery.

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Titel: Neuronal Connectivity, General Anesthesia, and the Elderly
Autor:: Ramachandran Ramani
Publikationsdatum: 01.12.2017
DOI: https://doi.org/10.1007/s40140-017-0241-6
Verlag: Springer US
Zeitschrift: Current Anesthesiology Reports
Ausgabe 4/2017
Elektronische ISSN: 2167-6275

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Neuronal Connectivity, General Anesthesia, and the Elderly

Abstract

Purpose of Review

Recent Findings

Summary

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Recent Findings

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