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01.02.2013 | Leitthema

Neurotoxizität von Allgemeinanästhetika im Kindesalter

Hinterlässt Narkose Spuren beim Früh-, Neugeborenen und Kleinkind?

verfasst von: Dr. B. Sinner, K. Becke, K. Engelhard

Erschienen in: Die Anaesthesiologie | Ausgabe 2/2013

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Zusammenfassung

Zahlreiche tierexperimentelle Untersuchungen zeigen, dass Anästhetika im unreifen Gehirn neurotoxisch wirken können, da sie Apoptose induzieren und die Neuro- sowie Synaptogenese beeinflussen. Im Tierexperiment hat dies erhebliche Auswirkungen auf die neurokognitiven Funktionen der Tiere im späteren Leben. Ob diese tierexperimentellen Ergebnisse auf den Menschen übertragen werden können, ist derzeit Gegenstand intensiver Forschung. In mehreren retrospektiven Untersuchungen konnte kein eindeutiger Zusammenhang zwischen einer Anästhesie im Früh-, Neugeborenen- oder Kleinkindalter und dem Auftreten von Lernstörungen oder Verhaltensauffälligkeiten gefunden werden. Zwei prospektive Studien (GAS und PANDA) sollen weiteren Einblick liefern und diese Frage möglichst klären. Wegen der großen Relevanz des Themas und um für die Problematik im Umgang mit den Eltern mehr Klarheit zu schaffen, haben der Wissenschaftliche Arbeitskreis für Kinderanästhesie und der Wissenschaftliche Arbeitskreis für Neuroanästhesie der Deutschen Gesellschaft für Anästhesiologie und Intensivmedizin (DGAI) auf der Grundlage der derzeitigen Datenlage eine Stellungnahme verfasst ().

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Titel: Neurotoxizität von Allgemeinanästhetika im Kindesalter
Hinterlässt Narkose Spuren beim Früh-, Neugeborenen und Kleinkind?
verfasst von: Dr. B. Sinner
K. Becke
K. Engelhard
Publikationsdatum: 01.02.2013
Verlag: Springer-Verlag
Erschienen in: Die Anaesthesiologie / Ausgabe 2/2013
Print ISSN: 2731-6858
Elektronische ISSN: 2731-6866
DOI: https://doi.org/10.1007/s00101-013-2139-0

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Neurotoxizität von Allgemeinanästhetika im Kindesalter

Hinterlässt Narkose Spuren beim Früh-, Neugeborenen und Kleinkind?

Zusammenfassung

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