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23.07.2020 | Scientific Article

Obese and overweight individuals have greater knee synovial inflammation and associated structural and cartilage compositional degeneration: data from the osteoarthritis initiative

verfasst von: Thanat Kanthawang, Jannis Bodden, Gabby B. Joseph, Nancy E. Lane, Michael Nevitt, Charles E. McCulloch, Thomas M. Link

Erschienen in: Skeletal Radiology | Ausgabe 1/2021

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Abstract

Objective

This work aims to study (i) the relationship between body mass index (BMI) and knee synovial inflammation using non-contrast-enhanced MRI and (ii) the association of synovial inflammation versus degenerative abnormalities and pain.

Materials and methods

Subjects with risk for and mild to moderate radiographic osteoarthritis were selected from the Osteoarthritis Initiative. Subjects were grouped into three BMI categories with 87 subjects per group: normal weight (BMI, 20–24.9 kg/m²), overweight (BMI, 25–29.9 kg/m²), and obese (BMI, ≥ 30 kg/m²), frequency matched for age, sex, race, Kellgren-Lawrence grade, and history of knee surgery and injury. Semi-quantitative synovial inflammation imaging biomarkers were obtained including effusion-synovitis, size and intensity of infrapatellar fat pad signal abnormality, and synovial proliferation score. Cartilage composition was measured using T₂ relaxation time and structural abnormalities using the whole-organ magnetic resonance imaging score (WORMS). The Western Ontario and McMasters (WOMAC) Osteoarthritis Index was used for pain assessment. Intra- and inter-reader reproducibility was assessed by kappa values.

Results

Overweight and obese groups had higher prevalence and severity of all synovial inflammatory markers (p ≤ 0.03). Positive associations were found between synovial inflammation imaging biomarkers and average T₂ values, WORMS maximum scores and total WOMAC pain scores (p < 0.05). Intra- and inter-reader kappa values for imaging biomarkers were high (0.76–1.00 and 0.60–0.94, respectively).

Conclusion

Being overweight or obese was significantly associated with a greater prevalence and severity of synovial inflammation imaging biomarkers. Substantial reproducibility and high correlation with knee structural, cartilage compositional degeneration, and WOMAC pain scores validate the synovial inflammation biomarkers used in this study.

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Titel: Obese and overweight individuals have greater knee synovial inflammation and associated structural and cartilage compositional degeneration: data from the osteoarthritis initiative
verfasst von: Thanat Kanthawang
Jannis Bodden
Gabby B. Joseph
Nancy E. Lane
Michael Nevitt
Charles E. McCulloch
Thomas M. Link
Publikationsdatum: 23.07.2020
Verlag: Springer Berlin Heidelberg
Erschienen in: Skeletal Radiology / Ausgabe 1/2021
Print ISSN: 0364-2348
Elektronische ISSN: 1432-2161
DOI: https://doi.org/10.1007/s00256-020-03550-5

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Obese and overweight individuals have greater knee synovial inflammation and associated structural and cartilage compositional degeneration: data from the osteoarthritis initiative