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28.07.2018 | Original Article

Oral administration of eicosapentaenoic acid suppresses liver fibrosis in postoperative patients with biliary atresia

verfasst von: Wataru Sumida, Hiroo Uchida, Takahisa Tainaka, Chiyoe Shirota, Akinari Hinoki, Takazumi Kato, Kazuki Yokota, Kazuo Oshima, Ryo Shirotuki, Kosuke Chiba, Yujiro Tanaka

Erschienen in: Pediatric Surgery International | Ausgabe 10/2018

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Abstract

Purpose

Biliary atresia (BA) is characterized by progressive inflammation of the biliary system. This inflammation persists and causes liver fibrosis, although jaundice disappears after Kasai portoenterostomy (KP). We aimed to confirm whether the oral administration of eicosapentaenoic acid (EPA) suppresses liver fibrosis in postoperative patients with BA.

Methods

We reviewed patients who underwent laparoscopic KP (lapKP) between January 2014 and September 2017. From December 2016, 30 mg/kg/day of EPA was orally administered to patients who opted to take medicine (EPA group). Patients who did not receive EPA were assigned to the non-EPA group. Mac-2 binding protein sugar chain modified isomer (M2BPGi) and hyaluronic acid (HA) levels were compared between the two groups in patients showing disappearance of jaundice at 6 months after the first lapKP.

Results

Seventeen patients in the non-EPA group and 11 in the EPA group were enrolled. At 6 months after the first lapKP, 10 patients in the non-EPA group and six in the EPA group were without jaundice. M2BPGi and HA levels were significantly lower in the EPA group.

Conclusions

Liver fibrosis was suppressed in patients without jaundice 6 months after lapKP, who were administered EPA. We believe that periductular inflammation was alleviated by EPA supplementation.

Harada K (2017) Sclerosing and obstructive cholangiopathy in biliary atresia: mechanisms and association with biliary innate immunity. Pediatr Surg Int 33(12):1243–1248. https://doi.org/10.1007/s00383-017-4154-8 CrossRefPubMed

Kasahara M, Umeshita K, Sakamoto S, Fukuda A, Furukawa H, Uemoto S (2017) Liver transplantation for biliary atresia: a systematic review. Pediatr Surg Int 33(12):1289–1295. https://doi.org/10.1007/s00383-017-4173-5 CrossRefPubMed

Sanada Y, Mizuta K, Urahashi T, Ihara Y, Wakiya T, Okada N, Yamada N, Egami S, Ushijima K, Otomo S, Sakamoto K, Yasuda Y, Kawarasaki H (2011) Indication of liver transplantation for jaundice-free biliary atresia with portal hypertension. Ann Transpl 16(4):7–11CrossRef

Das UN (2006) Essential fatty acids: biochemistry, physiology and pathology. Biotechnol J 1(4):420–439. https://doi.org/10.1002/biot.200600012 CrossRefPubMed

Nio M, Sasaki H, Tanaka H, Okamura A (2013) Redo surgery for biliary atresia. Pediatr Surg Int 29(10):989–993. https://doi.org/10.1007/s00383-013-3396-3 CrossRefPubMed

Bates MD, Bucuvalas JC, Alonso MH, Ryckman FC (1998) Biliary atresia: pathogenesis and treatment. Sem Liver Dis 18(3):281–293. https://doi.org/10.1055/s-2007-1007164 CrossRef

Nio M (2017) Japanese Biliary Atresia Registry. Pediatr Surg Int 33(12):1319–1325. https://doi.org/10.1007/s00383-017-4160-x CrossRefPubMed

Sumida W, Kaneko K, Ono Y, Tainaka T, Ando H (2009) Different polyunsaturated fatty acid profiles in patients with biliary atresia after successful Kasai operation and liver transplantation. Pediatr Surg Int 25(3):255–259. https://doi.org/10.1007/s00383-009-2324-z CrossRefPubMed

Lee S, Kim S, Le HD, Meisel J, Strijbosch RA, Nose V, Puder M (2008) Reduction of hepatocellular injury after common bile duct ligation using omega-3 fatty acids. J Pediatr Surg 43(11):2010–2015. https://doi.org/10.1016/j.jpedsurg.2008.05.030 CrossRefPubMed

10.

Dong R, Zheng S (2015) Interleukin-8: a critical chemokine in biliary atresia. J Gastroenterol Hepatol 30(6):970–976. https://doi.org/10.1111/jgh.12900 CrossRefPubMed

11.

Storey A, McArdle F, Friedmann PS, Jackson MJ, Rhodes LE (2005) Eicosapentaenoic acid and docosahexaenoic acid reduce UVB- and TNF-alpha-induced IL-8 secretion in keratinocytes and UVB-induced IL-8 in fibroblasts. J Invest Dermatol 124(1):248–255. https://doi.org/10.1111/j.0022-202X.2004.23543.x CrossRefPubMed

12.

Tang N, Zhang Y, Liu Z, Fu T, Liang Q, Ai X (2016) Correlation analysis between four serum biomarkers of liver fibrosis and liver function in infants with cholestasis. Biomed Rep 5(1):107–112. https://doi.org/10.3892/br.2016.681 CrossRefPubMedPubMedCentral

13.

Shirabe K, Bekki Y, Gantumur D, Araki K, Ishii N, Kuno A, Narimatsu H, Mizokami M (2018) Mac-2 binding protein glycan isomer (M2BPGi) is a new serum biomarker for assessing liver fibrosis: more than a biomarker of liver fibrosis. J Gastroenterol. https://doi.org/10.1007/s00535-017-1425-z PubMedCrossRef

14.

Yamada N, Sanada Y, Tashiro M, Hirata Y, Okada N, Ihara Y, Urahashi T, Mizuta K (2017) Serum Mac-2 binding protein glycosylation isomer predicts grade F4 liver fibrosis in patients with biliary atresia. J Gastroenterol 52(2):245–252. https://doi.org/10.1007/s00535-016-1235-8 CrossRefPubMed

15.

Hasegawa T, Sasaki T, Kimura T, Hoki M, Okada A, Mushiake S, Yagi M, Imura K (2000) Measurement of serum hyaluronic acid as a sensitive marker of liver fibrosis in biliary atresia. J Pediatr Surg 35(11):1643–1646CrossRefPubMed

Titel: Oral administration of eicosapentaenoic acid suppresses liver fibrosis in postoperative patients with biliary atresia
verfasst von: Wataru Sumida
Hiroo Uchida
Takahisa Tainaka
Chiyoe Shirota
Akinari Hinoki
Takazumi Kato
Kazuki Yokota
Kazuo Oshima
Ryo Shirotuki
Kosuke Chiba
Yujiro Tanaka
Publikationsdatum: 28.07.2018
Verlag: Springer Berlin Heidelberg
Erschienen in: Pediatric Surgery International / Ausgabe 10/2018
Print ISSN: 0179-0358
Elektronische ISSN: 1437-9813
DOI: https://doi.org/10.1007/s00383-018-4313-6

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Oral administration of eicosapentaenoic acid suppresses liver fibrosis in postoperative patients with biliary atresia

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Purpose

Methods

Results

Conclusions

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