Erschienen in:
01.09.2019 | Introduction
Osteoimmunology: entwined regulation of integrated systems
verfasst von:
Mary C. Nakamura
Erschienen in:
Seminars in Immunopathology
|
Ausgabe 5/2019
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Excerpt
Osteoimmunology is the study of the close interrelationships between the skeletal and the immune systems that begin in development and continue as important functional regulators of both systems throughout life. Bone is a complex organ which both houses and influences immune cell development, differentiation, and function. The osteoclast, the important bone degrading cell, is a highly differentiated immune cell which is regulated by similar mechanisms as its myeloid cell relatives. Conversely, bone cells can influence immune cell development and immune responses, which can also have a significant impact during disease pathology. This issue focused on osteoimmunology that includes a set of new reviews that emphasize how regulation of immune function occurs in concert with the regulation of bone turnover, which has significant implications for the outcomes of bone density and disease due to immune activation during infection, autoimmunity, and aging. …