The online version of this article (doi:10.1186/1477-7819-10-48) contains supplementary material, which is available to authorized users.
Zuozhang Yang, Yongqing Xu, Dakuan Yang, Hongpu Sun contributed equally to this work.
ZY was responsible for whole project design and manuscript writing; YX, DY, HS are in charge of establishment of animal model; RZ, XW, and JZ are in charge of data analysis; HJ, LX and JZ are in charge of data analysis and correction of manuscript. All the authors had read and approved the final manuscript.
Use a banna mini-pig to set up 125I implantation model, and investigate the consequence of radiation-related impairments.
In present study, 125I seeds were implanted into spinal canal of T13 level of spine in banna mini-pigs. After operation, the pigs were raised up to 8 months, behavior changes were recorded within this period. After 8 months, spinal cords were collected for pathological analysis.
In this study, a 125I brachytherapy animal model had been successfully established, in the model group, the banna pigs' Tarlov scale decreased from 5 to 2.57 ± 0.36, significant cellular impairments were noted by pathological analysis.
Without any protection and operation improvement, 125I implantation can cause serious histological impairments and moving difficulty for banna mini-pigs; this present research provides an alternative tool to study spinal 125I brachytherapy.
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- Pathological impairments induced by interstitial implantation of 125I Seeds in spinal canal of banna mini-pigs
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