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01.12.2012 | Research | Ausgabe 1/2012 Open Access

World Journal of Surgical Oncology 1/2012

Pathological impairments induced by interstitial implantation of 125I Seeds in spinal canal of banna mini-pigs

Zeitschrift:
World Journal of Surgical Oncology > Ausgabe 1/2012
Autoren:
Zuozhang Yang, Yongqing Xu, Dakuan Yang, Hongpu Sun, Ruilian Zhao, Jin Zhang, Xiaoxue Wang, Hua Jiang, Lie Xu, Jinlei Zhang
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​1477-7819-10-48) contains supplementary material, which is available to authorized users.
Zuozhang Yang, Yongqing Xu, Dakuan Yang, Hongpu Sun contributed equally to this work.

Authors' contributions

ZY was responsible for whole project design and manuscript writing; YX, DY, HS are in charge of establishment of animal model; RZ, XW, and JZ are in charge of data analysis; HJ, LX and JZ are in charge of data analysis and correction of manuscript. All the authors had read and approved the final manuscript.

Abstract

Background

Use a banna mini-pig to set up 125I implantation model, and investigate the consequence of radiation-related impairments.

Methods

In present study, 125I seeds were implanted into spinal canal of T13 level of spine in banna mini-pigs. After operation, the pigs were raised up to 8 months, behavior changes were recorded within this period. After 8 months, spinal cords were collected for pathological analysis.

Results

In this study, a 125I brachytherapy animal model had been successfully established, in the model group, the banna pigs' Tarlov scale decreased from 5 to 2.57 ± 0.36, significant cellular impairments were noted by pathological analysis.

Conclusions

Without any protection and operation improvement, 125I implantation can cause serious histological impairments and moving difficulty for banna mini-pigs; this present research provides an alternative tool to study spinal 125I brachytherapy.
Zusatzmaterial
Authors’ original file for figure 1
12957_2011_971_MOESM1_ESM.pdf
Authors’ original file for figure 2
12957_2011_971_MOESM2_ESM.pdf
Authors’ original file for figure 3
12957_2011_971_MOESM3_ESM.pdf
Authors’ original file for figure 4
12957_2011_971_MOESM4_ESM.pdf
Authors’ original file for figure 5
12957_2011_971_MOESM5_ESM.pdf
Authors’ original file for figure 6
12957_2011_971_MOESM6_ESM.pdf
Literatur
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