Erschienen in:
01.01.2007 | Correspondence
Pharmacokinetic/pharmacodynamic modelling of cardiac toxicity in venlafaxine overdose
verfasst von:
Bruno Mégarbane, Vanessa Bloch, Nicolas Deye, Frédéric J. Baud
Erschienen in:
Intensive Care Medicine
|
Ausgabe 1/2007
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Excerpt
Sir: We found the article by Isbister et al. [
1], presenting the pharmacokinetic/pharmacodynamic (PK/PD) model-based guidelines for managing citalopram poisoning-induced QT prolongation very interesting. The Bayesian methodology used by these authors is a useful tool for a population approach of data arising from overdoses. However, at the individual level and especially for patients with life-threatening symptoms, only single PK/PD relationships allow the quantitative characterization of the time-course of the in vivo drug effect in relation to its concentrations [
2]. Moreover, individual PK/PD approach is useful to assess any interindividual variability of the drug effects. …