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16.09.2016 | Original

Physical declines occurring after hospital discharge in ARDS survivors: a 5-year longitudinal study

verfasst von: Elizabeth R. Pfoh, Amy W. Wozniak, Elizabeth Colantuoni, Victor D. Dinglas, Pedro A. Mendez-Tellez, Carl Shanholtz, Nancy D. Ciesla, Peter J. Pronovost, Dale M. Needham

Erschienen in: Intensive Care Medicine | Ausgabe 10/2016

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Abstract

Purpose

Survivors of acute respiratory distress syndrome (ARDS) are at high risk for new or ongoing physical declines after hospital discharge. The objective of our study was to evaluate the epidemiology of physical declines over 5-year follow-up and identify patients at risk for decline.

Methods

This multi-site prospective cohort study evaluated ARDS survivors who completed a physical status assessment at 3 or 6 months post-discharge. Three measures were evaluated: muscle strength (Medical Resource Council sumscore); exercise capacity [6-min walk test (6MWT)]; physical functioning [36-Item Short Form Health Survey (SF-36 survey)]. Patients were defined as “declined” if a comparison of their current and prior score showed a decrease that was greater than the Reliable Change Index—or if the patient died. Risk factors [pre-ARDS baseline status, intensive care unit (ICU) illness severity, and other intensive care variables] were evaluated using longitudinal, generalized linear regression models for each measure.

Results

During the follow-up of 193 ARDS survivors (55 % male; median age 49 years), 166 (86 %) experienced decline in ≥1 physical measure (including death) and 133 (69 %) experienced a physical decline (excluding death). For all measures, age was a significant risk factor [odds ratios (OR) 1.34–1.69 per decade; p < 0.001]. Pre-ARDS comorbidity (Charlson Index) was independently associated with declines in strength and exercise capacity (OR 1.10 and 1.18, respectively; p < 0.02), and organ failure [maximum daily Sequential Organ Failure Assessment (SOFA) score in ICU] was associated with declines in strength (OR 1.06 per 1 point of SOFA score; p = 0.02).

Conclusions

Over the follow-up period, the majority of ARDS survivors experienced a physical decline, with older age and pre-ICU comorbidity being important risk factors for this decline.

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Titel: Physical declines occurring after hospital discharge in ARDS survivors: a 5-year longitudinal study
verfasst von: Elizabeth R. Pfoh
Amy W. Wozniak
Elizabeth Colantuoni
Victor D. Dinglas
Pedro A. Mendez-Tellez
Carl Shanholtz
Nancy D. Ciesla
Peter J. Pronovost
Dale M. Needham
Publikationsdatum: 16.09.2016
Verlag: Springer Berlin Heidelberg
Erschienen in: Intensive Care Medicine / Ausgabe 10/2016
Print ISSN: 0342-4642
Elektronische ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-016-4530-1

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Physical declines occurring after hospital discharge in ARDS survivors: a 5-year longitudinal study