Predictors of severe outcomes in patients with Clostridium difficile infection from a Hispanic population
- 17.12.2016
- Original Article
Erschienen in:
- Verfasst von
- Laura Paláu-Dávila
- Elvira Garza-González
- Eva María Gutiérrez-Delgado
- Adrián Camacho-Ortiz
- Erschienen in
- Indian Journal of Gastroenterology | Ausgabe 1/2017
Abstract
Background
Factors associated with complicated Clostridium difficile infection (CDI) may vary among populations, and predictors of severe outcomes in CDI have not been studied in Hispanic patients. The aim of this study was to identify factors associated with a higher risk of colectomy, all-cause mortality, and CDI-associated mortality in a Hispanic population.
Methods
We performed a retrospective study of all hospitalized patients with a diagnosis of CDI between January 1, 2011 and September 30, 2015 in a 450-bed teaching hospital in Monterrey, northeast Mexico. Three main outcomes were defined: fulminant colitis with subsequent colectomy, all-cause mortality within 30 days of diagnosis, and CDI-attributable mortality.
Results
Of 261 patients with diarrhea, 176 were diagnosed with CDI. For colectomy, Charlson comorbidity index, ICU stay and mechanical ventilation prior to CDI diagnosis, days with diarrhea prior to treatment, total days of hospital stay and days after CDI diagnosis, elevated ATLAS score, days of diarrhea post CDI treatment, and treatment failure significantly predicted the necessity of surgical treatment with colectomy.
Conclusion
Treatment failure, persistent diarrhea, and a high ATLAS score were identified as risk factors for severe outcomes of CDI. A low albumin concentration and high creatinine were associated with higher overall mortality.
Anzeige
- Titel
- Predictors of severe outcomes in patients with Clostridium difficile infection from a Hispanic population
- Verfasst von
-
Laura Paláu-Dávila
Elvira Garza-González
Eva María Gutiérrez-Delgado
Adrián Camacho-Ortiz
- Publikationsdatum
- 17.12.2016
- Verlag
- Springer India
- Erschienen in
-
Indian Journal of Gastroenterology / Ausgabe 1/2017
Print ISSN: 0254-8860
Elektronische ISSN: 0975-0711 - DOI
- https://doi.org/10.1007/s12664-016-0722-4
Dieser Inhalt ist nur sichtbar, wenn du eingeloggt bist und die entsprechende Berechtigung hast.
