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Erschienen in: World Journal of Pediatrics 4/2019

16.07.2019 | Review Article

Prevention and treatment of childhood and adolescent obesity: a systematic review of meta-analyses

verfasst von: Theodora Psaltopoulou, Stamatios Tzanninis, Ioannis Ntanasis-Stathopoulos, George Panotopoulos, Myrto Kostopoulou, Ioannis-Georgios Tzanninis, Anastasia Tsagianni, Theodoros N. Sergentanis

Erschienen in: World Journal of Pediatrics | Ausgabe 4/2019

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Abstract

Background

The goal of this systematic review is to synthesize the published meta-analyses assessing the role of nutritional, behavioral and physical activity factors/interventions on the prevention or treatment of pediatric and adolescent obesity.

Methods

An online search was conducted in PubMed (end-of-search: September 30, 2015); English-language meta-analyses pooling observational and/or interventional studies examining weight-related indices on children and adolescents were included.

Results

Sixty-six meta-analyses corresponding to more than 900,000 children and adolescents were retrieved. The majority of meta-analyses included interventional studies most of which referred to mixed or combined interventions, including components such as diet, physical activity and sedentary behavior reduction. Discrepancies between meta-analyses on observational and interventional studies were noted. Combined interventions including physical activity and nutritional modifications seemed to represent the most effective means for tackling childhood obesity.

Conclusions

Synthesis of interventional or observational evidence may yield discrepant results. The combination of enhanced physical activity and improved nutrition emerged as a promising intervention in the fight against childhood/adolescent obesity. However, further research is needed about the most effective multidimensional prevention strategy.
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Literatur
3.
Zurück zum Zitat Zwiauer KF. Prevention and treatment of overweight and obesity in children and adolescents. Eur J Pediatr. 2000;159(Suppl 1):S56–68.CrossRefPubMed Zwiauer KF. Prevention and treatment of overweight and obesity in children and adolescents. Eur J Pediatr. 2000;159(Suppl 1):S56–68.CrossRefPubMed
5.
Zurück zum Zitat Craigie AM, Lake AA, Kelly SA, Adamson AJ, Mathers JC. Tracking of obesity-related behaviours from childhood to adulthood: asystematic review. Maturitas. 2011;70:266–84.CrossRefPubMed Craigie AM, Lake AA, Kelly SA, Adamson AJ, Mathers JC. Tracking of obesity-related behaviours from childhood to adulthood: asystematic review. Maturitas. 2011;70:266–84.CrossRefPubMed
6.
Zurück zum Zitat Psaltopoulou T, Ilias I, Alevizaki M. The role of diet and lifestyle in primary, secondary, and tertiary diabetes prevention: a review of meta-analyses. Rev Diabet Stud. 2010;7:26–35.CrossRefPubMedPubMedCentral Psaltopoulou T, Ilias I, Alevizaki M. The role of diet and lifestyle in primary, secondary, and tertiary diabetes prevention: a review of meta-analyses. Rev Diabet Stud. 2010;7:26–35.CrossRefPubMedPubMedCentral
8.
Zurück zum Zitat Franks PW, Hanson RL, Knowler WC, Sievers ML, Bennett PH, Looker HC. Childhood obesity, other cardiovascular risk factors, and premature death. N Engl J Med. 2010;362:485–93.CrossRefPubMedPubMedCentral Franks PW, Hanson RL, Knowler WC, Sievers ML, Bennett PH, Looker HC. Childhood obesity, other cardiovascular risk factors, and premature death. N Engl J Med. 2010;362:485–93.CrossRefPubMedPubMedCentral
9.
Zurück zum Zitat Guh DP, Zhang W, Bansback N, Amarsi Z, Birmingham CL, Anis AH. The incidence of co-morbidities related to obesity and overweight: a systematic review and meta-analysis. BMC Public Health. 2009;9:88.CrossRefPubMedPubMedCentral Guh DP, Zhang W, Bansback N, Amarsi Z, Birmingham CL, Anis AH. The incidence of co-morbidities related to obesity and overweight: a systematic review and meta-analysis. BMC Public Health. 2009;9:88.CrossRefPubMedPubMedCentral
10.
Zurück zum Zitat Ebbeling CB, Pawlak DB, Ludwig DS. Childhood obesity: public-health crisis, common sense cure. Lancet. 2002;360:473–82.CrossRefPubMed Ebbeling CB, Pawlak DB, Ludwig DS. Childhood obesity: public-health crisis, common sense cure. Lancet. 2002;360:473–82.CrossRefPubMed
11.
Zurück zum Zitat Baker JL, Olsen LW, Sorensen TI. Childhood body-mass index and the risk of coronary heart disease in adulthood. N Engl J Med. 2007;357:2329–37.CrossRefPubMedPubMedCentral Baker JL, Olsen LW, Sorensen TI. Childhood body-mass index and the risk of coronary heart disease in adulthood. N Engl J Med. 2007;357:2329–37.CrossRefPubMedPubMedCentral
12.
Zurück zum Zitat Swinburn BA, Sacks G, Hall KD, McPherson K, Finegood DT, Moodie ML, et al. The global obesity pandemic: shaped by global drivers and local environments. Lancet. 2011;378:804–14.CrossRefPubMed Swinburn BA, Sacks G, Hall KD, McPherson K, Finegood DT, Moodie ML, et al. The global obesity pandemic: shaped by global drivers and local environments. Lancet. 2011;378:804–14.CrossRefPubMed
13.
Zurück zum Zitat Osei-Assibey G, Dick S, Macdiarmid J, Semple S, Reilly JJ, Ellaway A, et al. The influence of the food environment on overweight and obesity in young children: a systematic review. BMJ Open. 2012;2:e001538.CrossRefPubMedPubMedCentral Osei-Assibey G, Dick S, Macdiarmid J, Semple S, Reilly JJ, Ellaway A, et al. The influence of the food environment on overweight and obesity in young children: a systematic review. BMJ Open. 2012;2:e001538.CrossRefPubMedPubMedCentral
15.
Zurück zum Zitat Panic N, Leoncini E, de Belvis G, Ricciardi W, Boccia S. Evaluation of the endorsement of the preferred reporting items for systematic reviews and meta-analysis (PRISMA) statement on the quality of published systematic review and meta-analyses. PLoS ONE. 2013;8:e83138.CrossRefPubMedPubMedCentral Panic N, Leoncini E, de Belvis G, Ricciardi W, Boccia S. Evaluation of the endorsement of the preferred reporting items for systematic reviews and meta-analysis (PRISMA) statement on the quality of published systematic review and meta-analyses. PLoS ONE. 2013;8:e83138.CrossRefPubMedPubMedCentral
16.
Zurück zum Zitat Summerbell CD, Waters E, Edmunds LD, Kelly S, Brown T, Campbell KJ. Interventions for preventing obesity in children. Cochrane Database Syst Rev. 2005;3:CD001871. Summerbell CD, Waters E, Edmunds LD, Kelly S, Brown T, Campbell KJ. Interventions for preventing obesity in children. Cochrane Database Syst Rev. 2005;3:CD001871.
17.
Zurück zum Zitat Wang Y, Wu Y, Wilson RF, Bleich S, Cheskin L, Weston C, et al. Childhood Obesity Prevention Programs: Comparative Effectiveness Review and Meta-Analysis [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2013 Jun Report No: 13-EHC081-EF. Wang Y, Wu Y, Wilson RF, Bleich S, Cheskin L, Weston C, et al. Childhood Obesity Prevention Programs: Comparative Effectiveness Review and Meta-Analysis [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2013 Jun Report No: 13-EHC081-EF.
18.
Zurück zum Zitat Langford R, Bonell CP, Jones HE, Pouliou T, Murphy SM, Waters E, et al. The WHO Health Promoting School framework for improving the health and well-being of students and their academic achievement. Cochrane Database Syst Rev. 2014;4:CD008958. Langford R, Bonell CP, Jones HE, Pouliou T, Murphy SM, Waters E, et al. The WHO Health Promoting School framework for improving the health and well-being of students and their academic achievement. Cochrane Database Syst Rev. 2014;4:CD008958.
19.
Zurück zum Zitat Collins CE, Warren J, Neve M, McCoy P, Stokes BJ. Measuring effectiveness of dietetic interventions in child obesity: a systematic review of randomized trials. Arch Pediatr Adolesc Med. 2006;160:906–22.CrossRefPubMed Collins CE, Warren J, Neve M, McCoy P, Stokes BJ. Measuring effectiveness of dietetic interventions in child obesity: a systematic review of randomized trials. Arch Pediatr Adolesc Med. 2006;160:906–22.CrossRefPubMed
20.
Zurück zum Zitat Wang Y, Cai L, Wu Y, Wilson RF, Weston C, Fawole O, et al. What childhood obesity prevention programmes work? A systematic review and meta-analysis. Obes Rev. 2015;16:547–65.CrossRefPubMedPubMedCentral Wang Y, Cai L, Wu Y, Wilson RF, Weston C, Fawole O, et al. What childhood obesity prevention programmes work? A systematic review and meta-analysis. Obes Rev. 2015;16:547–65.CrossRefPubMedPubMedCentral
21.
Zurück zum Zitat Oude Luttikhuis H, Baur L, Jansen H, Shrewsbury VA, O'Malley C, Stolk RP, et al. Interventions for treating obesity in children. Cochrane Database Syst Rev. 2009;1:CD001872. Oude Luttikhuis H, Baur L, Jansen H, Shrewsbury VA, O'Malley C, Stolk RP, et al. Interventions for treating obesity in children. Cochrane Database Syst Rev. 2009;1:CD001872.
22.
Zurück zum Zitat Langford R, Bonell C, Jones H, Pouliou T, Murphy S, Waters E, et al. The World Health Organization's Health Promoting Schools framework: a Cochrane systematic review and meta-analysis. BMC Public Health. 2015;15:130.CrossRefPubMedPubMedCentral Langford R, Bonell C, Jones H, Pouliou T, Murphy S, Waters E, et al. The World Health Organization's Health Promoting Schools framework: a Cochrane systematic review and meta-analysis. BMC Public Health. 2015;15:130.CrossRefPubMedPubMedCentral
23.
Zurück zum Zitat Collins CE, Warren JM, Neve M, McCoy P, Stokes B. Systematic review of interventions in the management of overweight and obese children which include a dietary component. Int J Evid Based Healthc. 2007;5:2–53.PubMed Collins CE, Warren JM, Neve M, McCoy P, Stokes B. Systematic review of interventions in the management of overweight and obese children which include a dietary component. Int J Evid Based Healthc. 2007;5:2–53.PubMed
24.
Zurück zum Zitat Yang GP, Wang YR, Zuo SY, Zeng XM. Meta-analysis of intervention effects on obesity in Chinese pupils. Zhonghua Yu Fang Yi Xue Za Zhi. 2011;45:944–8 (in Chinese).PubMed Yang GP, Wang YR, Zuo SY, Zeng XM. Meta-analysis of intervention effects on obesity in Chinese pupils. Zhonghua Yu Fang Yi Xue Za Zhi. 2011;45:944–8 (in Chinese).PubMed
25.
Zurück zum Zitat Hooper L, Abdelhamid A, Moore HJ, Douthwaite W, Skeaff CM, Summerbell CD. Effect of reducing total fat intake on body weight: systematic review and meta-analysis of randomised controlled trials and cohort studies. BMJ. 2012;345:e7666.CrossRefPubMedPubMedCentral Hooper L, Abdelhamid A, Moore HJ, Douthwaite W, Skeaff CM, Summerbell CD. Effect of reducing total fat intake on body weight: systematic review and meta-analysis of randomised controlled trials and cohort studies. BMJ. 2012;345:e7666.CrossRefPubMedPubMedCentral
26.
Zurück zum Zitat Malik VS, Willett WC, Hu FB. Sugar-sweetened beverages and BMI in children and adolescents: reanalyses of a meta-analysis. Am J Clin Nutr. 2009;89:438–9.CrossRefPubMed Malik VS, Willett WC, Hu FB. Sugar-sweetened beverages and BMI in children and adolescents: reanalyses of a meta-analysis. Am J Clin Nutr. 2009;89:438–9.CrossRefPubMed
27.
Zurück zum Zitat Clark JE. Does the type intervention method really matter for combating childhood obesity? A systematic review and meta-analysis. J Sports Med Phys Fitness. 2015;55:1524–43.PubMed Clark JE. Does the type intervention method really matter for combating childhood obesity? A systematic review and meta-analysis. J Sports Med Phys Fitness. 2015;55:1524–43.PubMed
28.
Zurück zum Zitat Kaisari P, Yannakoulia M, Panagiotakos DB. Eating frequency and overweight and obesity in children and adolescents: a meta-analysis. Pediatrics. 2013;131:958–67.CrossRefPubMed Kaisari P, Yannakoulia M, Panagiotakos DB. Eating frequency and overweight and obesity in children and adolescents: a meta-analysis. Pediatrics. 2013;131:958–67.CrossRefPubMed
29.
Zurück zum Zitat Cook-Cottone C, Casey CM, Feeley TH, Baran J. A meta-analytic review of obesity prevention in the schools: 1997–2008. Psychol Schools. 2009;46:695–719.CrossRef Cook-Cottone C, Casey CM, Feeley TH, Baran J. A meta-analytic review of obesity prevention in the schools: 1997–2008. Psychol Schools. 2009;46:695–719.CrossRef
30.
Zurück zum Zitat Gonzalez-Suarez C, Worley A, Grimmer-Somers K, Dones V. School-based interventions on childhood obesity: a meta-analysis. Am J Prev Med. 2009;37:418–27.CrossRefPubMed Gonzalez-Suarez C, Worley A, Grimmer-Somers K, Dones V. School-based interventions on childhood obesity: a meta-analysis. Am J Prev Med. 2009;37:418–27.CrossRefPubMed
31.
Zurück zum Zitat Wilfley DE, Tibbs TL, Van Buren DJ, Reach KP, Walker MS, Epstein LH. Lifestyle interventions in the treatment of childhood overweight: a meta-analytic review of randomized controlled trials. Health Psychol. 2007;26:521–32.CrossRefPubMedPubMedCentral Wilfley DE, Tibbs TL, Van Buren DJ, Reach KP, Walker MS, Epstein LH. Lifestyle interventions in the treatment of childhood overweight: a meta-analytic review of randomized controlled trials. Health Psychol. 2007;26:521–32.CrossRefPubMedPubMedCentral
32.
Zurück zum Zitat Epstein LH, Goldfield GS. Physical activity in the treatment of childhood overweight and obesity: current evidence and research issues. Med Sci Sports Exerc. 1999;31(Suppl 11):S553–9.CrossRefPubMed Epstein LH, Goldfield GS. Physical activity in the treatment of childhood overweight and obesity: current evidence and research issues. Med Sci Sports Exerc. 1999;31(Suppl 11):S553–9.CrossRefPubMed
33.
Zurück zum Zitat Beets MW, Beighle A, Erwin HE, Huberty JL. After-school program impact on physical activity and fitness: a meta-analysis. Am J Prev Med. 2009;36:527–37.CrossRefPubMed Beets MW, Beighle A, Erwin HE, Huberty JL. After-school program impact on physical activity and fitness: a meta-analysis. Am J Prev Med. 2009;36:527–37.CrossRefPubMed
34.
Zurück zum Zitat Seo DC, Sa J. A meta-analysis of obesity interventions among US minority children. J Adolesc Health. 2010;46:309–23.CrossRefPubMed Seo DC, Sa J. A meta-analysis of obesity interventions among US minority children. J Adolesc Health. 2010;46:309–23.CrossRefPubMed
35.
Zurück zum Zitat Ho M, Garnett SP, Baur L, Burrows T, Stewart L, Neve M, et al. Effectiveness of lifestyle interventions in child obesity: systematic review with meta-analysis. Pediatrics. 2012;130:e1647–71.CrossRefPubMed Ho M, Garnett SP, Baur L, Burrows T, Stewart L, Neve M, et al. Effectiveness of lifestyle interventions in child obesity: systematic review with meta-analysis. Pediatrics. 2012;130:e1647–71.CrossRefPubMed
36.
Zurück zum Zitat Silveira JA, Taddei JA, Guerra PH, Nobre MR. The effect of participation in school-based nutrition education interventions on body mass index: a meta-analysis of randomized controlled community trials. Prev Med. 2013;56:237–43.CrossRefPubMed Silveira JA, Taddei JA, Guerra PH, Nobre MR. The effect of participation in school-based nutrition education interventions on body mass index: a meta-analysis of randomized controlled community trials. Prev Med. 2013;56:237–43.CrossRefPubMed
37.
Zurück zum Zitat Sbruzzi G, Eibel B, Barbiero SM, Petkowicz RO, Ribeiro RA, Cesa CC, et al. Educational interventions in childhood obesity: a systematic review with meta-analysis of randomized clinical trials. Prev Med. 2013;56:254–64.CrossRefPubMed Sbruzzi G, Eibel B, Barbiero SM, Petkowicz RO, Ribeiro RA, Cesa CC, et al. Educational interventions in childhood obesity: a systematic review with meta-analysis of randomized clinical trials. Prev Med. 2013;56:254–64.CrossRefPubMed
38.
Zurück zum Zitat Ho M, Garnett SP, Baur LA, Burrows T, Stewart L, Neve M, et al. Impact of dietary and exercise interventions on weight change and metabolic outcomes in obese children and adolescents: a systematic review and meta-analysis of randomized trials. JAMA Pediatr. 2013;167:759–68.CrossRefPubMed Ho M, Garnett SP, Baur LA, Burrows T, Stewart L, Neve M, et al. Impact of dietary and exercise interventions on weight change and metabolic outcomes in obese children and adolescents: a systematic review and meta-analysis of randomized trials. JAMA Pediatr. 2013;167:759–68.CrossRefPubMed
39.
Zurück zum Zitat Stice E, Shaw H, Marti CN. A meta-analytic review of obesity prevention programs for children and adolescents: the skinny on interventions that work. Psychol Bull. 2006;132:667–91.CrossRefPubMedPubMedCentral Stice E, Shaw H, Marti CN. A meta-analytic review of obesity prevention programs for children and adolescents: the skinny on interventions that work. Psychol Bull. 2006;132:667–91.CrossRefPubMedPubMedCentral
40.
Zurück zum Zitat Kamath CC, Vickers KS, Ehrlich A, McGovern L, Johnson J, Singhal V, et al. Clinical review: behavioral interventions to prevent childhood obesity: a systematic review and metaanalyses of randomized trials. J Clin Endocrinol Metab. 2008;93:4606–15.CrossRefPubMed Kamath CC, Vickers KS, Ehrlich A, McGovern L, Johnson J, Singhal V, et al. Clinical review: behavioral interventions to prevent childhood obesity: a systematic review and metaanalyses of randomized trials. J Clin Endocrinol Metab. 2008;93:4606–15.CrossRefPubMed
41.
Zurück zum Zitat Wilks DC, Mander AP, Jebb SA, Thompson SG, Sharp SJ, Turner RM, et al. Dietary energy density and adiposity: employing bias adjustments in a meta-analysis of prospective studies. BMC Public Health. 2011;11:48.CrossRefPubMedPubMedCentral Wilks DC, Mander AP, Jebb SA, Thompson SG, Sharp SJ, Turner RM, et al. Dietary energy density and adiposity: employing bias adjustments in a meta-analysis of prospective studies. BMC Public Health. 2011;11:48.CrossRefPubMedPubMedCentral
42.
Zurück zum Zitat Te Morenga L, Mallard S, Mann J. Dietary sugars and body weight: systematic review and meta-analyses of randomised controlled trials and cohort studies. BMJ. 2012;346:e7492.CrossRef Te Morenga L, Mallard S, Mann J. Dietary sugars and body weight: systematic review and meta-analyses of randomised controlled trials and cohort studies. BMJ. 2012;346:e7492.CrossRef
43.
Zurück zum Zitat de la Hunty A, Gibson S, Ashwell M. Does regular breakfast cereal consumption help children and adolescents stay slimmer? A systematic review and meta-analysis. Obes Facts. 2013;6:70–85.CrossRefPubMedPubMedCentral de la Hunty A, Gibson S, Ashwell M. Does regular breakfast cereal consumption help children and adolescents stay slimmer? A systematic review and meta-analysis. Obes Facts. 2013;6:70–85.CrossRefPubMedPubMedCentral
44.
Zurück zum Zitat Friedrich RR, Schuch I, Wagner MB. Effect of interventions on the body mass index of school-age students. Rev Saude Publica. 2012;46:551–60.CrossRefPubMed Friedrich RR, Schuch I, Wagner MB. Effect of interventions on the body mass index of school-age students. Rev Saude Publica. 2012;46:551–60.CrossRefPubMed
45.
Zurück zum Zitat Luckner H, Moss JR, Gericke CA. Effectiveness of interventions to promote healthy weight in general populations of children and adults: a meta-analysis. Eur J Public Health. 2012;22:491–7.CrossRefPubMed Luckner H, Moss JR, Gericke CA. Effectiveness of interventions to promote healthy weight in general populations of children and adults: a meta-analysis. Eur J Public Health. 2012;22:491–7.CrossRefPubMed
46.
Zurück zum Zitat Hammons AJ, Fiese BH. Is frequency of shared family meals related to the nutritional health of children and adolescents? Pediatrics. 2011;127:e1565–74.CrossRefPubMedPubMedCentral Hammons AJ, Fiese BH. Is frequency of shared family meals related to the nutritional health of children and adolescents? Pediatrics. 2011;127:e1565–74.CrossRefPubMedPubMedCentral
47.
Zurück zum Zitat Katz DL, O'Connell M, Njike VY, Yeh MC, Nawaz H. Strategies for the prevention and control of obesity in the school setting: systematic review and meta-analysis. Int J Obes (Lond). 2008;32:1780–9.CrossRef Katz DL, O'Connell M, Njike VY, Yeh MC, Nawaz H. Strategies for the prevention and control of obesity in the school setting: systematic review and meta-analysis. Int J Obes (Lond). 2008;32:1780–9.CrossRef
48.
Zurück zum Zitat McGovern L, Johnson JN, Paulo R, Hettinger A, Singhal V, Kamath C, et al. Clinical review: treatment of pediatric obesity: a systematic review and meta-analysis of randomized trials. J Clin Endocrinol Metab. 2008;93:4600–5.CrossRefPubMed McGovern L, Johnson JN, Paulo R, Hettinger A, Singhal V, Kamath C, et al. Clinical review: treatment of pediatric obesity: a systematic review and meta-analysis of randomized trials. J Clin Endocrinol Metab. 2008;93:4600–5.CrossRefPubMed
49.
Zurück zum Zitat Snethen JA, Broome ME, Cashin SE. Effective weight loss for overweight children: a meta-analysis of intervention studies. J Pediatr Nurs. 2006;21:45–56.CrossRefPubMed Snethen JA, Broome ME, Cashin SE. Effective weight loss for overweight children: a meta-analysis of intervention studies. J Pediatr Nurs. 2006;21:45–56.CrossRefPubMed
50.
Zurück zum Zitat Young KM, Northern JJ, Lister KM, Drummond JA, O'Brien WH. A meta-analysis of family-behavioral weight-loss treatments for children. Clin Psychol Rev. 2007;27:240–9.CrossRefPubMed Young KM, Northern JJ, Lister KM, Drummond JA, O'Brien WH. A meta-analysis of family-behavioral weight-loss treatments for children. Clin Psychol Rev. 2007;27:240–9.CrossRefPubMed
51.
Zurück zum Zitat Forshee RA, Anderson PA, Storey ML. Sugar-sweetened beverages and body mass index in children and adolescents: a meta-analysis. Am J Clin Nutr. 2008;87:1662–711.CrossRefPubMed Forshee RA, Anderson PA, Storey ML. Sugar-sweetened beverages and body mass index in children and adolescents: a meta-analysis. Am J Clin Nutr. 2008;87:1662–711.CrossRefPubMed
52.
Zurück zum Zitat Kanekar A, Sharma M. Meta-analysis of school-based childhood obesity interventions in the UK and US. Int Q Community Health Educ. 2008;29:241–56.CrossRefPubMed Kanekar A, Sharma M. Meta-analysis of school-based childhood obesity interventions in the UK and US. Int Q Community Health Educ. 2008;29:241–56.CrossRefPubMed
53.
Zurück zum Zitat Kitzmann KM, Dalton WT 3rd, Stanley CM, Beech BM, Reeves TP, Buscemi J, et al. Lifestyle interventions for youth who are overweight: a meta-analytic review. Health Psychol. 2010;29:91–101.CrossRefPubMed Kitzmann KM, Dalton WT 3rd, Stanley CM, Beech BM, Reeves TP, Buscemi J, et al. Lifestyle interventions for youth who are overweight: a meta-analytic review. Health Psychol. 2010;29:91–101.CrossRefPubMed
54.
Zurück zum Zitat Waters E, de Silva-Sanigorski A, Hall BJ, Brown T, Campbell KJ, Gao Y, et al. Interventions for preventing obesity in children. Cochrane Database Syst Rev. 2011;12:CD001871. Waters E, de Silva-Sanigorski A, Hall BJ, Brown T, Campbell KJ, Gao Y, et al. Interventions for preventing obesity in children. Cochrane Database Syst Rev. 2011;12:CD001871.
55.
Zurück zum Zitat Sobol-Goldberg S, Rabinowitz J, Gross R. School-based obesity prevention programs: a meta-analysis of randomized controlled trials. Obesity (Silver Spring). 2013;21:2422–8.CrossRef Sobol-Goldberg S, Rabinowitz J, Gross R. School-based obesity prevention programs: a meta-analysis of randomized controlled trials. Obesity (Silver Spring). 2013;21:2422–8.CrossRef
56.
Zurück zum Zitat Vasques C, Magalhaes P, Cortinhas A, Mota P, Leitao J, Lopes VP. Effects of intervention programs on child and adolescent BMI: ameta-analysis study. J Phys Act Health. 2014;11:426–44.CrossRefPubMed Vasques C, Magalhaes P, Cortinhas A, Mota P, Leitao J, Lopes VP. Effects of intervention programs on child and adolescent BMI: ameta-analysis study. J Phys Act Health. 2014;11:426–44.CrossRefPubMed
57.
Zurück zum Zitat Lavelle HV, Mackay DF, Pell JP. Systematic review and meta-analysis of school-based interventions to reduce body mass index. J Public Health (Oxf). 2012;34:360–9.CrossRef Lavelle HV, Mackay DF, Pell JP. Systematic review and meta-analysis of school-based interventions to reduce body mass index. J Public Health (Oxf). 2012;34:360–9.CrossRef
58.
Zurück zum Zitat Malik VS, Pan A, Willett WC, Hu FB. Sugar-sweetened beverages and weight gain in children and adults: a systematic review and meta-analysis. Am J Clin Nutr. 2013;98:1084–102.CrossRefPubMedPubMedCentral Malik VS, Pan A, Willett WC, Hu FB. Sugar-sweetened beverages and weight gain in children and adults: a systematic review and meta-analysis. Am J Clin Nutr. 2013;98:1084–102.CrossRefPubMedPubMedCentral
59.
Zurück zum Zitat LeMura LM, Maziekas MT. Factors that alter body fat, body mass, and fat-free mass in pediatric obesity. Med Sci Sports Exerc. 2002;34:487–96.CrossRefPubMed LeMura LM, Maziekas MT. Factors that alter body fat, body mass, and fat-free mass in pediatric obesity. Med Sci Sports Exerc. 2002;34:487–96.CrossRefPubMed
60.
Zurück zum Zitat Maziekas MT, LeMura LM, Stoddard NM, Kaercher S, Martucci T. Follow up exercise studies in paediatric obesity: implications for long term effectiveness. Br J Sports Med. 2003;37:425–9.CrossRefPubMedPubMedCentral Maziekas MT, LeMura LM, Stoddard NM, Kaercher S, Martucci T. Follow up exercise studies in paediatric obesity: implications for long term effectiveness. Br J Sports Med. 2003;37:425–9.CrossRefPubMedPubMedCentral
61.
Zurück zum Zitat Atlantis E, Barnes EH, Singh MA. Efficacy of exercise for treating overweight in children and adolescents: a systematic review. Int J Obes (Lond). 2006;30:1027–40.CrossRef Atlantis E, Barnes EH, Singh MA. Efficacy of exercise for treating overweight in children and adolescents: a systematic review. Int J Obes (Lond). 2006;30:1027–40.CrossRef
62.
Zurück zum Zitat Gilles A, Cassano M, Shepherd EJ, Higgins D, Hecker JE, Nangle DW. Comparing active pediatric obesity treatments using meta-analysis. J Clin Child Adolesc Psychol. 2008;37:886–92.CrossRefPubMed Gilles A, Cassano M, Shepherd EJ, Higgins D, Hecker JE, Nangle DW. Comparing active pediatric obesity treatments using meta-analysis. J Clin Child Adolesc Psychol. 2008;37:886–92.CrossRefPubMed
63.
Zurück zum Zitat Kelley GA, Kelley KS. Effects of aerobic exercise on non-high-density lipoprotein cholesterol in children and adolescents: a meta-analysis of randomized controlled trials. Prog Cardiovasc Nurs. 2008;23:128–32.CrossRefPubMedPubMedCentral Kelley GA, Kelley KS. Effects of aerobic exercise on non-high-density lipoprotein cholesterol in children and adolescents: a meta-analysis of randomized controlled trials. Prog Cardiovasc Nurs. 2008;23:128–32.CrossRefPubMedPubMedCentral
64.
Zurück zum Zitat Harris KC, Kuramoto LK, Schulzer M, Retallack JE. Effect of school-based physical activity interventions on body mass index in children: a meta-analysis. CMAJ. 2009;180:719–26.CrossRefPubMedPubMedCentral Harris KC, Kuramoto LK, Schulzer M, Retallack JE. Effect of school-based physical activity interventions on body mass index in children: a meta-analysis. CMAJ. 2009;180:719–26.CrossRefPubMedPubMedCentral
65.
Zurück zum Zitat Wilks DC, Sharp SJ, Ekelund U, Thompson SG, Mander AP, Turner RM, et al. Objectively measured physical activity and fat mass in children: a bias-adjusted meta-analysis of prospective studies. PLoS ONE. 2011;6:e17205.CrossRefPubMedPubMedCentral Wilks DC, Sharp SJ, Ekelund U, Thompson SG, Mander AP, Turner RM, et al. Objectively measured physical activity and fat mass in children: a bias-adjusted meta-analysis of prospective studies. PLoS ONE. 2011;6:e17205.CrossRefPubMedPubMedCentral
66.
Zurück zum Zitat van Grieken A, Ezendam NP, Paulis WD, van der Wouden JC, Raat H. Primary prevention of overweight in children and adolescents: a meta-analysis of the effectiveness of interventions aiming to decrease sedentary behaviour. Int J Behav Nutr Phys Act. 2012;9:61.CrossRefPubMedPubMedCentral van Grieken A, Ezendam NP, Paulis WD, van der Wouden JC, Raat H. Primary prevention of overweight in children and adolescents: a meta-analysis of the effectiveness of interventions aiming to decrease sedentary behaviour. Int J Behav Nutr Phys Act. 2012;9:61.CrossRefPubMedPubMedCentral
67.
Zurück zum Zitat Dobbins M, Husson H, DeCorby K, LaRocca RL. School-based physical activity programs for promoting physical activity and fitness in children and adolescents aged 6 to 18. Cochrane Database Syst Rev. 2013;2:CD007651. Dobbins M, Husson H, DeCorby K, LaRocca RL. School-based physical activity programs for promoting physical activity and fitness in children and adolescents aged 6 to 18. Cochrane Database Syst Rev. 2013;2:CD007651.
68.
Zurück zum Zitat Schranz N, Tomkinson G, Olds T. What is the effect of resistance training on the strength, body composition and psychosocial status of overweight and obese children and adolescents? A systematic review and meta-analysis. Sports Med. 2013;43:893–907.CrossRefPubMed Schranz N, Tomkinson G, Olds T. What is the effect of resistance training on the strength, body composition and psychosocial status of overweight and obese children and adolescents? A systematic review and meta-analysis. Sports Med. 2013;43:893–907.CrossRefPubMed
69.
Zurück zum Zitat Dellert JC, Johnson P. Interventions with children and parents to improve physical activity and body mass index: a meta-analysis. Am J Health Promot. 2014;28:259–67.CrossRefPubMed Dellert JC, Johnson P. Interventions with children and parents to improve physical activity and body mass index: a meta-analysis. Am J Health Promot. 2014;28:259–67.CrossRefPubMed
70.
Zurück zum Zitat Nogueira RC, Weeks BK, Beck BR. Exercise to improve pediatric bone and fat: a systematic review and meta-analysis. Med Sci Sports Exerc. 2014;46:610–21.CrossRefPubMed Nogueira RC, Weeks BK, Beck BR. Exercise to improve pediatric bone and fat: a systematic review and meta-analysis. Med Sci Sports Exerc. 2014;46:610–21.CrossRefPubMed
71.
Zurück zum Zitat Williams AJ, Henley WE, Williams CA, Hurst AJ, Logan S, Wyatt KM. Systematic review and meta-analysis of the association between childhood overweight and obesity and primary school diet and physical activity policies. Int J Behav Nutr Phys Act. 2013;10:101.CrossRefPubMedPubMedCentral Williams AJ, Henley WE, Williams CA, Hurst AJ, Logan S, Wyatt KM. Systematic review and meta-analysis of the association between childhood overweight and obesity and primary school diet and physical activity policies. Int J Behav Nutr Phys Act. 2013;10:101.CrossRefPubMedPubMedCentral
72.
Zurück zum Zitat Guerra PH, Nobre MR, Silveira JA, Taddei JA. The effect of school-based physical activity interventions on body mass index: a meta-analysis of randomized trials. Clinics (Sao Paulo). 2013;68:1263–73.CrossRefPubMedPubMedCentral Guerra PH, Nobre MR, Silveira JA, Taddei JA. The effect of school-based physical activity interventions on body mass index: a meta-analysis of randomized trials. Clinics (Sao Paulo). 2013;68:1263–73.CrossRefPubMedPubMedCentral
73.
Zurück zum Zitat Guerra PH, Nobre MR, da Silveira JA, Taddei JA. School-based physical activity and nutritional education interventions on body mass index: a meta-analysis of randomised community trials-project PANE. Prev Med. 2014;61:81–9.CrossRefPubMed Guerra PH, Nobre MR, da Silveira JA, Taddei JA. School-based physical activity and nutritional education interventions on body mass index: a meta-analysis of randomised community trials-project PANE. Prev Med. 2014;61:81–9.CrossRefPubMed
74.
Zurück zum Zitat Liao Y, Liao J, Durand CP, Dunton GF. Which type of sedentary behaviour intervention is more effective at reducing body mass index in children? A meta-analytic review. Obes Rev. 2014;15:159–68.CrossRefPubMed Liao Y, Liao J, Durand CP, Dunton GF. Which type of sedentary behaviour intervention is more effective at reducing body mass index in children? A meta-analytic review. Obes Rev. 2014;15:159–68.CrossRefPubMed
75.
Zurück zum Zitat Martin A, Saunders DH, Shenkin SD, Sproule J. Lifestyle intervention for improving school achievement in overweight or obese children and adolescents. Cochrane Database Syst Rev. 2014;3:CD09728. Martin A, Saunders DH, Shenkin SD, Sproule J. Lifestyle intervention for improving school achievement in overweight or obese children and adolescents. Cochrane Database Syst Rev. 2014;3:CD09728.
76.
Zurück zum Zitat Dror DK. Dairy consumption and pre-school, school-age and adolescent obesity in developed countries: a systematic review and meta-analysis. Obes Rev. 2014;15:516–27.CrossRefPubMed Dror DK. Dairy consumption and pre-school, school-age and adolescent obesity in developed countries: a systematic review and meta-analysis. Obes Rev. 2014;15:516–27.CrossRefPubMed
77.
Zurück zum Zitat Garcia-Hermoso A, Saavedra JM, Escalante Y, Sanchez-Lopez M, Martinez-Vizcaino V. Endocrinology and Adolescence: aerobic exercise reduces insulin resistance markers in obese youth: a meta-analysis of randomized controlled trials. Eur J Endocrinol. 2014;171:R163–R171.CrossRefPubMed Garcia-Hermoso A, Saavedra JM, Escalante Y, Sanchez-Lopez M, Martinez-Vizcaino V. Endocrinology and Adolescence: aerobic exercise reduces insulin resistance markers in obese youth: a meta-analysis of randomized controlled trials. Eur J Endocrinol. 2014;171:R163–R171.CrossRefPubMed
78.
Zurück zum Zitat Cesa CC, Sbruzzi G, Ribeiro RA, Barbiero SM, de Oliveira Petkowicz R, Eibel B, et al. Physical activity and cardiovascular risk factors in children: meta-analysis of randomized clinical trials. Prev Med. 2014;69:54–62.CrossRefPubMed Cesa CC, Sbruzzi G, Ribeiro RA, Barbiero SM, de Oliveira Petkowicz R, Eibel B, et al. Physical activity and cardiovascular risk factors in children: meta-analysis of randomized clinical trials. Prev Med. 2014;69:54–62.CrossRefPubMed
79.
Zurück zum Zitat Kelley GA, Kelley KS, Pate RR. Effects of exercise on BMI z-score in overweight and obese children and adolescents: a systematic review with meta-analysis. BMC Pediatr. 2014;14:225.CrossRefPubMedPubMedCentral Kelley GA, Kelley KS, Pate RR. Effects of exercise on BMI z-score in overweight and obese children and adolescents: a systematic review with meta-analysis. BMC Pediatr. 2014;14:225.CrossRefPubMedPubMedCentral
80.
Zurück zum Zitat van Hoek E, Feskens EJ, Bouwman LI, Janse AJ. Effective interventions in overweight or obese young children: systematic review and meta-analysis. Child Obes. 2014;10:448–60.CrossRefPubMed van Hoek E, Feskens EJ, Bouwman LI, Janse AJ. Effective interventions in overweight or obese young children: systematic review and meta-analysis. Child Obes. 2014;10:448–60.CrossRefPubMed
81.
Zurück zum Zitat Brown T, Smith S, Bhopal R, Kasim A, Summerbell C. Diet and physical activity interventions to prevent or treat obesity in South Asian children and adults: a systematic review and meta-analysis. Int J Environ Res Public Health. 2015;12:566–94.CrossRefPubMedPubMedCentral Brown T, Smith S, Bhopal R, Kasim A, Summerbell C. Diet and physical activity interventions to prevent or treat obesity in South Asian children and adults: a systematic review and meta-analysis. Int J Environ Res Public Health. 2015;12:566–94.CrossRefPubMedPubMedCentral
82.
Zurück zum Zitat Hung LS, Tidwell DK, Hall ME, Lee ML, Briley CA, Hunt BP. A meta-analysis of school-based obesity prevention programs demonstrates limited efficacy of decreasing childhood obesity. Nutr Res. 2015;35:229–40.CrossRefPubMed Hung LS, Tidwell DK, Hall ME, Lee ML, Briley CA, Hunt BP. A meta-analysis of school-based obesity prevention programs demonstrates limited efficacy of decreasing childhood obesity. Nutr Res. 2015;35:229–40.CrossRefPubMed
83.
Zurück zum Zitat Peirson L, Fitzpatrick-Lewis D, Morrison K, Ciliska D, Kenny M, Usman Ali M, et al. Prevention of overweight and obesity in children and youth: a systematic review and meta-analysis. CMAJ Open. 2015;3:E23–33.CrossRefPubMedPubMedCentral Peirson L, Fitzpatrick-Lewis D, Morrison K, Ciliska D, Kenny M, Usman Ali M, et al. Prevention of overweight and obesity in children and youth: a systematic review and meta-analysis. CMAJ Open. 2015;3:E23–33.CrossRefPubMedPubMedCentral
84.
Zurück zum Zitat Peirson L, Fitzpatrick-Lewis D, Morrison K, Warren R, Usman Ali M, Raina P. Treatment of overweight and obesity in children and youth: a systematic review and meta-analysis. CMAJ Open. 2015;3:E35–46.CrossRefPubMedPubMedCentral Peirson L, Fitzpatrick-Lewis D, Morrison K, Warren R, Usman Ali M, Raina P. Treatment of overweight and obesity in children and youth: a systematic review and meta-analysis. CMAJ Open. 2015;3:E35–46.CrossRefPubMedPubMedCentral
85.
Zurück zum Zitat Tremblay MS, LeBlanc AG, Kho ME, Saunders TJ, Larouche R, Colley RC, et al. Systematic review of sedentary behaviour and health indicators in school-aged children and youth. Int J Behav Nutr Phys Act. 2011;8:98.CrossRefPubMedPubMedCentral Tremblay MS, LeBlanc AG, Kho ME, Saunders TJ, Larouche R, Colley RC, et al. Systematic review of sedentary behaviour and health indicators in school-aged children and youth. Int J Behav Nutr Phys Act. 2011;8:98.CrossRefPubMedPubMedCentral
86.
Zurück zum Zitat Wahi G, Parkin PC, Beyene J, Uleryk EM, Birken CS. Effectiveness of interventions aimed at reducing screen time in children: a systematic review and meta-analysis of randomized controlled trials. Arch Pediatr Adolesc Med. 2011;165:979–86.CrossRefPubMed Wahi G, Parkin PC, Beyene J, Uleryk EM, Birken CS. Effectiveness of interventions aimed at reducing screen time in children: a systematic review and meta-analysis of randomized controlled trials. Arch Pediatr Adolesc Med. 2011;165:979–86.CrossRefPubMed
87.
Zurück zum Zitat Niemeier BS, Hektner JM, Enger KB. Parent participation in weight-related health interventions for children and adolescents: a systematic review and meta-analysis. Prev Med. 2012;55:3–13.CrossRefPubMed Niemeier BS, Hektner JM, Enger KB. Parent participation in weight-related health interventions for children and adolescents: a systematic review and meta-analysis. Prev Med. 2012;55:3–13.CrossRefPubMed
88.
Zurück zum Zitat Hooper L, Abdelhamid A, Bunn D, Brown T, Summerbell CD, Skeaff CM. Effects of total fat intake on body weight. Cochrane Database Syst Rev. 2015;8:11834. Hooper L, Abdelhamid A, Bunn D, Brown T, Summerbell CD, Skeaff CM. Effects of total fat intake on body weight. Cochrane Database Syst Rev. 2015;8:11834.
89.
Zurück zum Zitat Pérez-Escamilla R, Obbagy JE, Altman JM, Essery EV, McGrane MM, Wong YP, et al. Dietary energy density and body weight in adults and children: a systematic review. J Acad Nutr Diet. 2012;112:671–84.CrossRefPubMed Pérez-Escamilla R, Obbagy JE, Altman JM, Essery EV, McGrane MM, Wong YP, et al. Dietary energy density and body weight in adults and children: a systematic review. J Acad Nutr Diet. 2012;112:671–84.CrossRefPubMed
90.
Zurück zum Zitat Brown AW, Bohan Brown MM, Allison DB. Belief beyond the evidence: using the proposed effect of breakfast on obesity to show 2 practices that distort scientific evidence. Am J Clin Nutr. 2013;98:1298–308.CrossRefPubMedPubMedCentral Brown AW, Bohan Brown MM, Allison DB. Belief beyond the evidence: using the proposed effect of breakfast on obesity to show 2 practices that distort scientific evidence. Am J Clin Nutr. 2013;98:1298–308.CrossRefPubMedPubMedCentral
91.
Zurück zum Zitat Roberts CK. Combined diet and exercise interventions can improve metabolic outcomes in obese children, even with only small changes in weight. Evid Based Med. 2014;19:e9.CrossRefPubMed Roberts CK. Combined diet and exercise interventions can improve metabolic outcomes in obese children, even with only small changes in weight. Evid Based Med. 2014;19:e9.CrossRefPubMed
92.
Zurück zum Zitat Kaluski DN, Meir C, Rotem N, Zadka P. Sources of nutritional data in Israel. Public Health Rev. 1998;26:73–7.PubMed Kaluski DN, Meir C, Rotem N, Zadka P. Sources of nutritional data in Israel. Public Health Rev. 1998;26:73–7.PubMed
93.
Zurück zum Zitat Bes-Rastrollo M, Martinez-Gonzalez MA. Differential underreporting and other caveats about sugar-sweetened beverages and weight gain. Am J Clin Nutr. 2008;88:1450–1.CrossRefPubMed Bes-Rastrollo M, Martinez-Gonzalez MA. Differential underreporting and other caveats about sugar-sweetened beverages and weight gain. Am J Clin Nutr. 2008;88:1450–1.CrossRefPubMed
94.
Zurück zum Zitat Larson NI, Neumark-Sztainer D, Hannan PJ, Story M. Family meals during adolescence are associated with higher diet quality and healthful meal patterns during young adulthood. J Am Diet Assoc. 2007;107:1502–10.CrossRefPubMed Larson NI, Neumark-Sztainer D, Hannan PJ, Story M. Family meals during adolescence are associated with higher diet quality and healthful meal patterns during young adulthood. J Am Diet Assoc. 2007;107:1502–10.CrossRefPubMed
95.
Zurück zum Zitat Tsiros MD, Sinn N, Coates AM, Howe PR, Buckley JD. Treatment of adolescent overweight and obesity. Eur J Pediatr. 2008;167:9–16.CrossRefPubMed Tsiros MD, Sinn N, Coates AM, Howe PR, Buckley JD. Treatment of adolescent overweight and obesity. Eur J Pediatr. 2008;167:9–16.CrossRefPubMed
96.
Zurück zum Zitat Janssen I, Leblanc AG. Systematic review of the health benefits of physical activity and fitness in school-aged children and youth. Int J Behav Nutr Phys Act. 2010;7:40.CrossRefPubMedPubMedCentral Janssen I, Leblanc AG. Systematic review of the health benefits of physical activity and fitness in school-aged children and youth. Int J Behav Nutr Phys Act. 2010;7:40.CrossRefPubMedPubMedCentral
97.
Zurück zum Zitat Benson AC, Torode ME, Fiatarone Singh MA. Effects of resistance training on metabolic fitness in children and adolescents: a systematic review. Obes Rev. 2008;9:43–66.CrossRefPubMed Benson AC, Torode ME, Fiatarone Singh MA. Effects of resistance training on metabolic fitness in children and adolescents: a systematic review. Obes Rev. 2008;9:43–66.CrossRefPubMed
98.
Zurück zum Zitat Kelley GA, Kelley KS. Effects of exercise in the treatment of overweight and obese children and adolescents: a systematic review of meta-analyses. J Obes. 2013;2013:783103.CrossRefPubMedPubMedCentral Kelley GA, Kelley KS. Effects of exercise in the treatment of overweight and obese children and adolescents: a systematic review of meta-analyses. J Obes. 2013;2013:783103.CrossRefPubMedPubMedCentral
99.
Zurück zum Zitat Guyatt GH, Haynes RB, Jaeschke RZ, Cook DJ, Green L, Naylor CD, et al. Users' Guides to the Medical Literature: XXV Evidence-based medicine: principles for applying the Users' Guides to patient care Evidence-Based Medicine Working Group. JAMA. 2000;284:1290–6.CrossRefPubMed Guyatt GH, Haynes RB, Jaeschke RZ, Cook DJ, Green L, Naylor CD, et al. Users' Guides to the Medical Literature: XXV Evidence-based medicine: principles for applying the Users' Guides to patient care Evidence-Based Medicine Working Group. JAMA. 2000;284:1290–6.CrossRefPubMed
100.
Zurück zum Zitat American College of Sports Medicine. ACSM's guidelines for exercise testing and prescription. 10th ed. Baltimore: Lippincott, Williams and Wilkins; 2017. American College of Sports Medicine. ACSM's guidelines for exercise testing and prescription. 10th ed. Baltimore: Lippincott, Williams and Wilkins; 2017.
101.
Zurück zum Zitat Committee on Obesity Prevention Policies for Young Children. Early childhood obesity prevention policies. Washington: The National Academies Press; 2011. Committee on Obesity Prevention Policies for Young Children. Early childhood obesity prevention policies. Washington: The National Academies Press; 2011.
102.
Zurück zum Zitat Barlow SE; Expert Committee. Expert committee recommendations regarding the prevention, assessment, and treatment of child and adolescent overweight and obesity: summary report. Pediatrics. 2007;120(Suppl 4):S164–92.CrossRef Barlow SE; Expert Committee. Expert committee recommendations regarding the prevention, assessment, and treatment of child and adolescent overweight and obesity: summary report. Pediatrics. 2007;120(Suppl 4):S164–92.CrossRef
103.
Zurück zum Zitat Speiser PW, Rudolf MC, Anhalt H, Camacho-Hubner C, Chiarelli F, Eliakim A, et al. Childhood obesity. J Clin Endocrinol Metab. 2005;90:1871–87.CrossRefPubMed Speiser PW, Rudolf MC, Anhalt H, Camacho-Hubner C, Chiarelli F, Eliakim A, et al. Childhood obesity. J Clin Endocrinol Metab. 2005;90:1871–87.CrossRefPubMed
Metadaten
Titel
Prevention and treatment of childhood and adolescent obesity: a systematic review of meta-analyses
verfasst von
Theodora Psaltopoulou
Stamatios Tzanninis
Ioannis Ntanasis-Stathopoulos
George Panotopoulos
Myrto Kostopoulou
Ioannis-Georgios Tzanninis
Anastasia Tsagianni
Theodoros N. Sergentanis
Publikationsdatum
16.07.2019
Verlag
Springer Singapore
Erschienen in
World Journal of Pediatrics / Ausgabe 4/2019
Print ISSN: 1708-8569
Elektronische ISSN: 1867-0687
DOI
https://doi.org/10.1007/s12519-019-00266-y

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