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European Radiology
Erschienen in: European Radiology 5/2017

05.09.2016 | Gastrointestinal

Prognostic aspects of dynamic contrast-enhanced magnetic resonance imaging in synchronous distant metastatic rectal cancer

verfasst von: Jing Yu, Qing Xu, Dong-Ya Huang, Jia-Cheng Song, Yan Li, Lu-Lu Xu, Hai-Bin Shi

Erschienen in: European Radiology | Ausgabe 5/2017

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Abstract

Objectives

To explore the correlations between DCE-MRI quantitative parameters and synchronous distant metastasis and the clinicopathological factors in rectal cancers.

Methods

Sixty-three patients with rectal cancer (synchronous distant metastasis, n = 31; non-metastasis, n = 32) were enrolled in this study. Student’s t test and ANOVA were used to compare DCE-MRI parameters (K trans , K ep and V e ). The receiver operating characteristic (ROC) analysis was used to find the reasonable threshold of DCE-MRI parameters to differentiate lesions with synchronous distant metastasis from those without metastasis.

Results

The K trans , K ep , and V e value were significantly higher in the lesions with distant metastasis than in the lesions without distant metastasis (0.536 ± 0.242 vs. 0.299 ± 0.118 min-1, p < 0.001; 1.598 ± 0.477 vs. 1.341 ± 0.390 min-1, p = 0.022; and 0.324 ± 0.173 vs. 0.249 ± 0.091, p = 0.034; respectively). The K trans showed the highest AUCs of 0.788 (p < 0.001), with sensitivity of 61.29 % and specificity of 87.5 %, respectively.

Conclusions

DCE-MRI parameters may represent a prognostic indicator for synchronous distant metastases in patients with rectal cancer.

Key Points

• The K trans , K ep and V e values correlated with synchronous distant metastasis.
• Higher K trans , K ep and V e values were noted among patients with metastasis.
• DCE-MRI parameters might represent a prognostic indicator for synchronous distant metastases.
Literatur
1.
Engelen SM, Maas M, Lahaye MJ, Leijtens JW, van Berlo CL, Jansen RL et al (2013) Modern multidisciplinary treatment of rectal cancer based on staging with magnetic resonance imaging leads to excellent local control, but distant control remains a challenge. Eur J Cancer 49:2311–2320CrossRefPubMed
2.
Meguerditchian AN, Bairati I, Lagace R, Harel F, Kibrite A (2005) Prognostic significance of lymphovascular invasion in surgically cured rectal carcinoma. Am J Surg 189:707–713CrossRefPubMed
3.
Hong HS, Kim SH, Park HJ, Park MS, Kim KW, Kim WH et al (2013) Correlations of dynamic contrast-enhanced magnetic resonance imaging with morphologic, angiogenic, and molecular prognostic factors in rectal cancer. Yonsei Med J 54:123–130CrossRefPubMed
4.
Shihab OC, Moran BJ, Heald RJ, Quirke P, Brown G (2009) MRI staging of low rectal cancer. Eur Radiol 19:643–650CrossRefPubMed
5.
Li L, Wang K, Sun X, Wang K, Sun Y, Zhang G et al (2015) Parameters of dynamic contrast-enhanced MRI as imaging markers for angiogenesis and proliferation in human breast cancer. Med Sci Monit 21:376–382CrossRefPubMedPubMedCentral
6.
Lollert A, Junginger T, Schimanski CC, Biesterfeld S, Gockel I, Duber C et al (2014) Rectal cancer: dynamic contrast-enhanced MRI correlates with lymph node status and epidermal growth factor receptor expression. J Magn Reson Imaging 39:1436–1442CrossRefPubMed
7.
Padhani AR (2002) Dynamic contrast-enhanced MRI in clinical oncology: current status and future directions. J Magn Reson Imaging 16:407–422CrossRefPubMed
8.
Tofts PS, Brix G, Buckley DL, Evelhoch JL, Henderson E, Knopp MV et al (1999) Estimating kinetic parameters from dynamic contrast-enhanced T(1)-weighted MRI of a diffusable tracer: standardized quantities and symbols. J Magn Reson Imaging 10:223–232CrossRefPubMed
9.
DeLong ER, DeLong DM, Clarke-Pearson DL (1988) Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. Biometrics 44:837–845CrossRefPubMed
10.
Schisterman EF, Perkins NJ, Liu A, Bondell H (2005) Optimal cut-point and its corresponding Youden Index to discriminate individual using pooled blood samples. Epidemiology 16:73–81CrossRefPubMed
11.
Fidler IJ, Ellis LM (1994) The implications of angiogenesis for the biology and therapy of cancer metastasis. Cell 79:185–188CrossRefPubMed
12.
Koo HR, Cho N, Song IC, Kim H, Chang JM, Yi A et al (2012) Correlation of perfusion parameters on dynamic contrast-enhanced MRI with prognostic factors and subtypes of breast cancers. J Magn Reson Imaging 36:145–151CrossRefPubMed
13.
Chen J, Qian T, Zhang H, Wei C, Meng F, Yin H (2016) Combining dynamic contrast enhanced magnetic resonance imaging and microvessel density to assess the angiogenesis after PEI in a rabbit VX2 liver tumor model. Magn Reson Imaging 34:177–182CrossRefPubMed
14.
Yeo DM, Oh SN, Jung CK, Lee MA, Oh ST, Rha SE et al (2015) Correlation of dynamic contrast-enhanced MRI perfusion parameters with angiogenesis and biologic aggressiveness of rectal cancer: preliminary results. J Magn Reson Imaging 41:474–480CrossRefPubMed
15.
Gollub MJ, Cao K, Gultekin DH, Kuk D, Gonen M, Sohn M et al (2013) Prognostic aspects of DCE-MRI in recurrent rectal cancer. Eur Radiol 23:3336–3344CrossRefPubMed
16.
17.
Christofori G, Semb H (1999) The role of the cell-adhesion molecule E-cadherin as a tumour-suppressor gene. Trends Biochem Sci 24:73–76CrossRefPubMed
18.
Herzig M, Savarese F, Novatchkova M, Semb H, Christofori G (2007) Tumor progression induced by the loss of E-cadherin independent of beta-catenin/Tcf-mediated Wnt signaling. Oncogene 26:2290–2298CrossRefPubMed
19.
Awasthi R, Rathore RK, Soni P, Sahoo P, Awasthi A, Husain N et al (2012) Discriminant analysis to classify glioma grading using dynamic contrast-enhanced MRI and immunohistochemical markers. Neuroradiology 54:205–213CrossRefPubMed
20.
Jia Z, Geng D, Xie T, Zhang J, Liu Y (2012) Quantitative analysis of neovascular permeability in glioma by dynamic contrast-enhanced MR imaging. J Clin Neurosci 19:820–823CrossRefPubMed
21.
Huh JW, Kim CH, Lim SW, Kim HR, Kim YJ (2013) Early recurrence in patients undergoing curative surgery for colorectal cancer: is it a predictor for poor overall survival? Int J Colorectal Dis 28:1143–1149CrossRefPubMed
22.
Wang L, Zhong XG, Peng YF, Li ZW, Gu J (2014) Prognostic value of pretreatment level of carcinoembryonic antigen on tumour downstaging and early occurring metastasis in locally advanced rectal cancer following neoadjuvant radiotherapy (30 Gy in 10 fractions). Colorectal Dis 16:33–39CrossRefPubMed
23.
24.
Davenport MS, Heye T, Dale BM, Horvath JJ, Breault SR, Feuerlein S et al (2013) Inter- and intra-rater reproducibility of quantitative dynamic contrast enhanced MRI using TWIST perfusion data in a uterine fibroid model. J Magn Reson Imaging 38:329–335CrossRefPubMed
25.
Sohn B, Lim JS, Kim H, Myoung S, Choi J, Kim NK et al (2015) MRI-detected extramural vascular invasion is an independent prognostic factor for synchronous metastasis in patients with rectal cancer. Eur Radiol 25:1347–1355CrossRefPubMed
26.
Kim YC, Kim JK, Kim MJ, Lee JH, Kim YB, Shin SJ (2016) Feasibility of mesorectal vascular invasion in predicting early distant metastasis in patients with stage T3 rectal cancer based on rectal MRI. Eur Radiol 26:297–305CrossRefPubMed
27.
Betge J, Pollheimer MJ, Lindtner RA, Kornprat P, Schlemmer A, Rehak P et al (2012) Intramural and extramural vascular invasion in colorectal cancer: prognostic significance and quality of pathology reporting. Cancer 118:628–638CrossRefPubMed
28.
Gunther K, Dworak O, Remke S, Pfluger R, Merkel S, Hohenberger W et al (2002) Prediction of distant metastases after curative surgery for rectal cancer. J Surg Res 103:68–78CrossRefPubMed
29.
Lim SB, Yu CS, Jang SJ, Kim TW, Kim JH, Kim JC (2010) Prognostic significance of lymphovascular invasion in sporadic colorectal cancer. Dis Colon Rectum 53:377–384CrossRefPubMed
30.
Glynne-Jones R, Anyamene N, Moran B, Harrison M (2012) Neoadjuvant chemotherapy in MRI-staged high-risk rectal cancer in addition to or as an alternative to preoperative chemoradiation? Ann Oncol 23:2517–2526CrossRefPubMed
31.
Chua YJ, Barbachano Y, Cunningham D, Oates JR, Brown G, Wotherspoon A et al (2010) Neoadjuvant capecitabine and oxaliplatin before chemoradiotherapy and total mesorectal excision in MRI-defined poor-risk rectal cancer: a phase 2 trial. Lancet Oncol 11:241–248CrossRefPubMed
32.
Scharitzer M, Ba-Ssalamah A, Ringl H, Kolblinger C, Grunberger T, Weber M et al (2013) Preoperative evaluation of colorectal liver metastases: comparison between gadoxetic acid-enhanced 3.0-T MRI and contrast-enhanced MDCT with histopathological correlation. Eur Radiol 23:2187–2196CrossRefPubMed
Metadaten
Titel
Prognostic aspects of dynamic contrast-enhanced magnetic resonance imaging in synchronous distant metastatic rectal cancer
verfasst von
Jing Yu
Qing Xu
Dong-Ya Huang
Jia-Cheng Song
Yan Li
Lu-Lu Xu
Hai-Bin Shi
Publikationsdatum
05.09.2016
Verlag
Springer Berlin Heidelberg
Erschienen in
European Radiology / Ausgabe 5/2017
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-016-4532-y

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