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01.04.2009 | Original

Protective effects of glycyrrhizin in a gut hypoxia (ischemia)-reoxygenation (reperfusion) model

verfasst von: Rosanna Di Paola, Marta Menegazzi, Emanuela Mazzon, Tiziana Genovese, Concetta Crisafulli, Martina Dal Bosco, Zhenzhen Zou, Hisanori Suzuki, Salvatore Cuzzocrea

Erschienen in: Intensive Care Medicine | Ausgabe 4/2009

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Abstract

Purpose

This study investigated the effects of glycyrrhizin, a potent antioxidant, on tissue injury caused by ischemia/reperfusion (I/R) of the gut.

Methods

I/R injury of the intestine was caused by clamping both the superior mesenteric artery and the celiac trunk for 45 min followed by release of the clamp allowing reperfusion for 1 or 6 h.

Results

Administration of glycyrrhizin, significantly reduced the (a) fall of mean arterial blood pressure, (b) mortality rate, (c) myeloperoxidase (MPO) activity, (d) production of pro-inflammatory cytokines [tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β)], (e) histological evidence of gut injury, (f) immunoreactivity of nitrotyrosine, (g) poly ADP-ribose (PAR) formation, (h) the expression of ICAM-1 and P-selectin, (i) activation of nuclear factor-κB (NF-κB) and (j) signal transducer and activator transcription-3 (STAT-3) induced by splanchnic artery occlusion–reperfusion shock.

Conclusions

This study demonstrates that glycyrrhizin exerts multiple protective effects in splanchnic artery occlusion–reperfusion shock.

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Titel: Protective effects of glycyrrhizin in a gut hypoxia (ischemia)-reoxygenation (reperfusion) model
verfasst von: Rosanna Di Paola
Marta Menegazzi
Emanuela Mazzon
Tiziana Genovese
Concetta Crisafulli
Martina Dal Bosco
Zhenzhen Zou
Hisanori Suzuki
Salvatore Cuzzocrea
Publikationsdatum: 01.04.2009
Verlag: Springer-Verlag
Erschienen in: Intensive Care Medicine / Ausgabe 4/2009
Print ISSN: 0342-4642
Elektronische ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-008-1334-y

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Protective effects of glycyrrhizin in a gut hypoxia (ischemia)-reoxygenation (reperfusion) model