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Metabolic Brain Disease

Erschienen in:

01.03.2008 | Original Paper

Protein phosphatase-2A is activated in pig brain following cardiac arrest and resuscitation

verfasst von: Tao T. Zhang, Jimcy Platholi, Paul M. Heerdt, Hugh C. Hemmings Jr., H. Y. L. Tung

Erschienen in: Metabolic Brain Disease | Ausgabe 1/2008

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Abstract

Protein phosphatase-2A (PP-2A) interacts with several regulators of cell death pathways and is therefore a potential component of signaling pathways linking global cerebral ischemia to cell death. Using a novel procedure to quantify PP-2A activity, we find that cardiac arrest with resuscitation and reperfusion leads to activation of PP-2A by 1.6-fold in pig brain extract and by 3.4-fold after partial purification of PP-2A. This is the first demonstration of PP-2A activation in a clinically relevant model of transient global cerebral ischemia. These results suggest that inhibition of PP-2A activity may be neuroprotective in global cerebral ischemia.

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Titel: Protein phosphatase-2A is activated in pig brain following cardiac arrest and resuscitation
verfasst von: Tao T. Zhang
Jimcy Platholi
Paul M. Heerdt
Hugh C. Hemmings Jr.
H. Y. L. Tung
Publikationsdatum: 01.03.2008
Verlag: Springer US
Erschienen in: Metabolic Brain Disease / Ausgabe 1/2008
Print ISSN: 0885-7490
Elektronische ISSN: 1573-7365
DOI: https://doi.org/10.1007/s11011-007-9074-1

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