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01.03.2018 | Biomechanics (G Niebur and J Wallace, Section Editors) | Ausgabe 2/2018

Current Osteoporosis Reports 2/2018

Recent Advances in Understanding Bisphosphonate Effects on Bone Mechanical Properties

Zeitschrift:
Current Osteoporosis Reports > Ausgabe 2/2018
Autor:
Matthew R. Allen
Wichtige Hinweise
This article is part of the Topical Collection on Biomechanics

Abstract

Purpose of the Review

Bisphosphonates have well-established effects on suppressing bone resorption and slowing bone loss, yet the effects on bone mechanical properties are less clear. We review recent data from pre-clinical and clinical experiments that assessed mechanical properties of bisphosphonate-treated specimens.

Recent Findings

Pre-clinical work has utilized new techniques to show reduced fatigue life and transfer of stress from the mineral to collagen. Several notable studies have examined mechanical properties of tissue from patients treated with bisphosphonates with mixed results. Pre-clinical data suggest effects on mechanics may be independent of remodeling suppression.

Summary

The direct effect of bisphosphonates on bone mechanics remains unclear but recent work has set a solid foundation for the coming years.

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Literatur
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