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Current Osteoporosis Reports

Erschienen in:

23.02.2018 | Bone Marrow and Adipose Tissue (G Duque and B Lecka-Czernik, Section Editors)

Marrow Adiposity and Hematopoiesis in Aging and Obesity: Exercise as an Intervention

verfasst von: Vihitaben S. Patel, M. Ete Chan, Janet Rubin, Clinton T. Rubin

Erschienen in: Current Osteoporosis Reports | Ausgabe 2/2018

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Abstract

Purpose of Review

Changes in the bone marrow microenvironment, which accompany aging and obesity, including increased marrow adiposity, can compromise hematopoiesis. Here, we review deleterious shifts in molecular, cellular, and tissue activity and consider the potential of exercise to slow degenerative changes associated with aging and obesity.

Recent Findings

While bone marrow hematopoietic stem cells (HSC) are increased in frequency and myeloid-biased with age, the effect of obesity on HSC proliferation and differentiation remains controversial. HSC from both aged and obese environment have reduced hematopoietic reconstitution capacity following bone marrow transplant. Increased marrow adiposity affects HSC function, causing upregulation of myelopoiesis and downregulation of lymphopoiesis. Exercise, in contrast, can reduce marrow adiposity and restore hematopoiesis.

Summary

The impact of marrow adiposity on hematopoiesis is determined mainly through correlations. Mechanistic studies are needed to determine a causative relationship between marrow adiposity and declines in hematopoiesis, which could aid in developing treatments for conditions that arise from disruptions in the marrow microenvironment.

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Titel: Marrow Adiposity and Hematopoiesis in Aging and Obesity: Exercise as an Intervention
verfasst von: Vihitaben S. Patel
M. Ete Chan
Janet Rubin
Clinton T. Rubin
Publikationsdatum: 23.02.2018
Verlag: Springer US
Erschienen in: Current Osteoporosis Reports / Ausgabe 2/2018
Print ISSN: 1544-1873
Elektronische ISSN: 1544-2241
DOI: https://doi.org/10.1007/s11914-018-0424-1

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Springer Medizin

Marrow Adiposity and Hematopoiesis in Aging and Obesity: Exercise as an Intervention

Abstract

Purpose of Review

Recent Findings

Summary

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Arthroskopie kann Knieprothese nicht hinauszögern

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Stereotaktische Radiatio schlägt konventionelle Bestrahlung

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Springer Medizin

Abstract

Purpose of Review

Recent Findings

Summary

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