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Inflammation Research

Erschienen in:

02.04.2024 | Review

Recognition of Mycobacterium tuberculosis by macrophage Toll-like receptor and its role in autophagy

verfasst von: Linna Wei, Liping Liu, Zudi Meng, Kai Qi, Xuehan Gao, Jihong Feng, Junmin Luo

Erschienen in: Inflammation Research | Ausgabe 5/2024

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Abstract

Background

The pathogen responsible for tuberculosis is called Mycobacterium tuberculosis. Its interaction with macrophages has a significant impact on the onset and progression of the disease.

Methods

The respiratory pathway allows Mycobacterium tuberculosis to enter the body's lungs where it battles immune cells before being infected latently or actively. In the progress of tuberculosis, Mycobacterium tuberculosis activates the body's immune system and creates inflammatory factors, which cause tissue inflammation to infiltrate and the creation of granulomas, which seriously harms the body. Toll-like receptors of macrophage can mediate host recognition of Mycobacterium tuberculosis, initiate immune responses, and participate in macrophage autophagy. New host-directed therapeutic approaches targeting autophagy for drug-resistant Mycobacterium tuberculosis have emerged, providing new ideas for the effective treatment of tuberculosis.

Conclusions

In-depth understanding of the mechanisms by which macrophage autophagy interacts with intracellular Mycobacterium tuberculosis, as well as the study of potent and specific autophagy-regulating molecules, will lead to much-needed advances in drug discovery and vaccine design, which will improve the prevention and treatment of human tuberculosis.

Global tuberculosis report 2023. Geneva: World Health Organization; 2023. Licence: CC BY-NC-SA 3.0 IGO.

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Titel: Recognition of Mycobacterium tuberculosis by macrophage Toll-like receptor and its role in autophagy
verfasst von: Linna Wei
Liping Liu
Zudi Meng
Kai Qi
Xuehan Gao
Jihong Feng
Junmin Luo
Publikationsdatum: 02.04.2024
Verlag: Springer International Publishing
Erschienen in: Inflammation Research / Ausgabe 5/2024
Print ISSN: 1023-3830
Elektronische ISSN: 1420-908X
DOI: https://doi.org/10.1007/s00011-024-01864-x

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Recognition of Mycobacterium tuberculosis by macrophage Toll-like receptor and its role in autophagy

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